Defects in tendon, ligament, and enthesis in response to genetic alterations in key proteoglycans and glycoproteins: a review.
Toronto, Canada. In Arthritis, 2012
The genes reviewed are for small leucine-rich proteoglycans (lumican, fibromodulin, biglycan, decorin, and asporin); dermatan sulfate epimerase (Dse) that alters structure of glycosaminoglycan and hence the function of small leucine-rich proteoglycans by converting glucuronic to iduronic acid; matricellular proteins (thrombospondin 2, secreted phosphoprotein 1 (Spp1), secreted protein acidic and rich in cysteine (Sparc), periostin, and tenascin X) including human tenascin C variants; and others, such as tenomodulin, leukocyte cell derived chemotaxin 1 (chondromodulin-I, ChM-I), CD44 antigen (Cd44), lubricin (Prg4), and aggrecan degrading gene, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (Adamts5).
Residual structure in unfolded proteins.
Missoula, United States. In Curr Opin Struct Biol, 2012
The denatured state ensemble (DSE) of unfolded proteins, once considered to be well-modeled by an energetically featureless random coil, is now well-known to contain flickering elements of residual structure.
[Progress on cis-acting regulatory elements in nonsense-mediated mRNA decay].
Guangzhou, China. In Yi Chuan Xue Bao, 2004
They are PTC presence, PTC recongnation by downstream elements that termed as downstream sequence element (DSE) in yeast and primarily exon-exon junction ( EEJ) in mammalian cells, stabilizer sequence (STE) inactivation the NMD, and other sequences correlated with NMD such as extended poly (A) in 3' UTRs,upstream open reading frame (uORF) located in 5' UTR and programmed -1 ribosomal frameshift (-1 PRF).