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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Regulator of calcineurin 1

DSCR1, RCAN1, MCIP1, Adapt78
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, AGE, HAD, vascular endothelial growth factor
Papers on DSCR1
Targeting myocardial reperfusion injuries with cyclosporine in the CIRCUS Trial - Pharmacological reasons for failure.
New
Pathak et al., Strasbourg, France. In Fundam Clin Pharmacol, Jan 2016
Finally, CsA blocks calcineurin, a protein implied in I/R damage but calcineurin inhibition could contribute to protection towards I/R damage only when Rcan1, a calcineurin natural inhibitor, expression is low.
The calcineurin inhibitor, Sarah/Nebula, exacerbates Aβ42 phenotypes in a Drosophila model of Alzheimer's disease.
New
Cho et al., Seoul, South Korea. In Dis Model Mech, Jan 2016
UNASSIGNED: Expression of the Down syndrome critical region 1 (DSCR1) protein, an inhibitor of the Ca(2+)-dependent phosphatase calcineurin, is elevated in the brains of patients with Down syndrome (DS) or Alzheimer's disease (AD).
RCAN1 overexpression promotes age-dependent mitochondrial dysregulation related to neurodegeneration in Alzheimer's disease.
New
Hoeffer et al., New York City, United States. In Acta Neuropathol, Nov 2015
Patients with Down syndrome (DS) develop symptoms consistent with early-onset AD, suggesting that overexpression of chromosome 21 genes such as Regulator of Calcineurin 1 (RCAN1) plays a role in AD pathogenesis.
Association Between DSCR1 Variations and Congenital Heart Disease Susceptibility.
Li et al., Beijing, China. In Med Sci Monit, 2014
BACKGROUND The objective of this study was aimed to detect the association of Down syndrome critical region 1 (DSCR1) gene polymorphisms (rs149048873 and rs143081213) and congenital heart disease (CHD) susceptibility.
Aberrant expression of RCAN1 in Alzheimer's pathogenesis: a new molecular mechanism and a novel drug target.
Review
Song et al., Vancouver, Canada. In Mol Neurobiol, 2014
Growing evidences indicate that dysregulation of regulator of calcineurin 1 (RCAN1) plays an important role in the pathogenesis of AD.
RCAN1 links impaired neurotrophin trafficking to aberrant development of the sympathetic nervous system in Down syndrome.
Kuruvilla et al., Baltimore, United States. In Nat Commun, 2014
We show that excess regulator of calcineurin 1 (RCAN1), an endogenous inhibitor of the calcineurin phosphatase that is triplicated in Down syndrome, impairs neurotrophic support of sympathetic neurons by inhibiting endocytosis of the nerve growth factor (NGF) receptor, TrkA.
Chaperone-mediated autophagy regulates T cell responses through targeted degradation of negative regulators of T cell activation.
Impact
Macian et al., New York City, United States. In Nat Immunol, 2014
In activated T cells, CMA targeted the ubiquitin ligase Itch and the calcineurin inhibitor RCAN1 for degradation to maintain activation-induced responses.
The regulator of calcineurin (RCAN1) an important factor involved in atherosclerosis and cardiovascular diseases development.
Review
Atanasiu et al., Bucureşti, Romania. In J Med Life, 2014
RCAN1 is a regulator of calcineurin, both of them being calcium dependent proteins.
Roles for ATF6 and the sarco/endoplasmic reticulum protein quality control system in the heart.
Review
Glembotski, San Diego, United States. In J Mol Cell Cardiol, 2014
Two ATF6-inducible genes that have been studied in the heart and shown to be adaptive are RCAN1 and Derl3, which encode proteins that decrease protein-folding demand, and enhance degradation of misfolded proteins, respectively.
Oxidative stress and Down syndrome. Do antioxidants play a role in therapy?
Review
Ďuračková et al., Bratislava, Slovakia. In Physiol Res, 2013
Trisomy 21 in patients with DS results in increased activity of an important antioxidant enzyme Cu/Zn superoxide dismutase (SOD) which gene is located on the 21st chromosome along with other proteins such as transcription factor Ets-2, stress inducing factors (DSCR1) and precursor of beta-amyloid protein responsible for the formation of amyloid plaques in Alzheimer disease.
Chronic high levels of the RCAN1-1 protein may promote neurodegeneration and Alzheimer disease.
Review
Davies et al., Los Angeles, United States. In Free Radic Biol Med, 2013
The RCAN1 gene encodes three different protein isoforms: RCAN1-4, RCAN1-1L, and RCAN1-1S.
Chronic expression of RCAN1-1L protein induces mitochondrial autophagy and metabolic shift from oxidative phosphorylation to glycolysis in neuronal cells.
GeneRIF
Davies et al., Los Angeles, United States. In J Biol Chem, 2012
RCAN1-1L protein induces mitochondrial autophagy and metabolic shift from oxidative phosphorylation to glycolysis in neuronal cells
The transcription factor STAT2 enhances proteasomal degradation of RCAN1 through the ubiquitin E3 ligase FBW7.
GeneRIF
Chung et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2012
Co-immunoprecipitation/immunoblot analyses showed that STAT2 enhanced RCAN1 ubiquitination through the ubiquitin E3 ligase FBW7.
Fecal corticosterone levels in RCAN1 mutant mice.
GeneRIF
Hoeffer et al., United States. In Comp Med, 2012
Data indicate normal diurnal corticosterone production in RCAN1 mutant mice and do not suggest a causal role in either the cognitive or anxiety phenotypes exhibited by RCAN1-knockout mice.
Protein kinase A phosphorylates Down syndrome critical region 1 (RCAN1).
GeneRIF
Seo et al., Ch'unch'ŏn, South Korea. In Biochem Biophys Res Commun, 2012
these data provide the first evidence that PKA acts as an important regulatory component in the control of RCAN1 function through phosphorylation.
Regulator of calcineurin 1 (Rcan1) has a protective role in brain ischemia/reperfusion injury.
GeneRIF
Cano et al., Madrid, Spain. In J Neuroinflammation, 2011
In this study we report that Rcan1-4 protein and mRNA levels are increased after brain ischemia/reperfusion injury in mice model.
Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome.
Impact
Hodivala-Dilke et al., London, United Kingdom. In Nature, 2010
3) or DS candidate region 1 (DSCR1) genes (a previously known suppressor of angiogenesis) is sufficient to inhibit tumour growth.
Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1.
Impact
GeneRIF
Ryeom et al., Boston, United States. In Nature, 2009
the modest increase in expression afforded by a single extra transgenic copy of Dscr1 is sufficient to confer significant suppression of tumour growth in mice
Interaction between TAK1-TAB1-TAB2 and RCAN1-calcineurin defines a signalling nodal control point.
Impact
Molkentin et al., Cincinnati, United States. In Nat Cell Biol, 2009
The calcium-activated protein phosphatase calcineurin is controlled by regulator of calcineurin (RCAN) in organisms ranging from yeast to mammals.
Targeted deletion of the calcineurin inhibitor DSCR1 suppresses tumor growth.
Impact
GeneRIF
McKeon et al., Boston, United States. In Cancer Cell, 2008
Targeted deletion of Dscr1 leads to hyperactivated calcineurin and precocious endothelial apoptosis, inhibiting formation of an effective tumor vasculature and suppressing tumorigenesis.
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