Oxidative stress and Down syndrome. Do antioxidants play a role in therapy?
Bratislava, Slovakia. In Physiol Res, 2013
Trisomy 21 in patients with DS results in increased activity of an important antioxidant enzyme Cu/Zn superoxide dismutase (SOD) which gene is located on the 21st chromosome along with other proteins such as transcription factor Ets-2, stress inducing factors (DSCR1) and precursor of beta-amyloid protein responsible for the formation of amyloid plaques in Alzheimer disease.
Fecal corticosterone levels in RCAN1 mutant mice.
United States. In Comp Med, 2012
Data indicate normal diurnal corticosterone production in RCAN1 mutant mice and do not suggest a causal role in either the cognitive or anxiety phenotypes exhibited by RCAN1-knockout mice.