CHD2-Related Neurodevelopmental Disorders
Seattle, United States. In Unknown Journal, Jan 2016
CLINICAL CHARACTERISTICS: CHD2-related neurodevelopmental disorders are characterized by early-onset epileptic encephalopathy (i.e., refractory seizures and cognitive slowing or regression associated with frequent ongoing epileptiform activity).
Role of DSCAM in the development of the spinal locomotor and sensorimotor circuits.
Laval, France. In J Neurophysiol, Jan 2016
Several studies in invertebrates and vertebrates have argued that the Down Syndrome Cell Adhesion Molecule (DSCAM) would play an important role in the normal development of neural circuits through cell spacing and targeting, axonal and dendritic branching, and synapse establishment and maintenance.
Review of Dscam-mediated immunity in shrimp and other arthropods.
Tainan City, Taiwan. In Dev Comp Immunol, 2014
However, while vertebrate antibodies have no invertebrate homolog, the Down syndrome cell adhesion molecule (Dscam), which is a hypervariable protein created by alternative splicing, can function as a pathogen-specific recognizing molecule in arthropods.
Netrins and their roles in placental angiogenesis.
Montigny-le-Bretonneux, France. In Biomed Res Int, 2013
These opposite effects appear to be related to the endothelial cell phenotype studied and seem also to depend on the receptor type to which netrin binds, that is, the canonical receptor member of the DCC family, the members of the UNC5 family, or the noncanonical receptor members of the integrin family or DSCAM.
Protocadherins mediate dendritic self-avoidance in the mammalian nervous system.
Cambridge, United States. In Nature, 2012
In many respects, our results mirror those reported for Dscam1 (Down syndrome cell adhesion molecule) in Drosophila: this complex gene encodes thousands of recognition molecules that exhibit stochastic expression and isoform-specific interactions, and mediate both self-avoidance and self/non-self discrimination.