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Developmentally regulated GTP binding protein 2

DRG2
This gene encodes a GTP-binding protein known to function in the regulation of cell growth and differentiation. Read-through transcripts containing this gene and a downstream gene have been identified, but they are not thought to encode a fusion protein. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jan 2012] (from NCBI)
Top mentioned proteins: NDRG1, V1a, Rac1, POLYMERASE, FATE
Papers on DRG2
Developmentally regulated GTP-binding protein 2 coordinates Rab5 activity and transferrin recycling.
New
Park et al., Ulsan, South Korea. In Mol Biol Cell, Feb 2016
Here we report that recruitment of RabGAP5 is insufficient to deactivate Rab5 and that developmentally regulated GTP-binding protein 2 (DRG2) is required for Rab5 deactivation and Tfn recycling.
MicroRNA‑1915‑3p prevents the apoptosis of lung cancer cells by downregulating DRG2 and PBX2.
New
Lu et al., Beijing, China. In Mol Med Report, Jan 2016
Developmentally regulated GTP‑binding protein 2 (DRG2) and pre‑B cell leukemia homeobox 2 (PBX2) were identified as downstream targets of miR‑1915‑3p, which was shown to bind directly to the 3'‑untranslated region of DRG2 and PBX2, subsequently lowering their mRNA and protein expression levels.
Developmentally regulated GTP-binding protein 2 ameliorates EAE by suppressing the development of TH17 cells.
Park et al., Ulsan, South Korea. In Clin Immunol, 2014
Developmentally regulated GTP-binding protein 2 (DRG2) represents a novel subclass of GTP-binding proteins.
Overexpression of developmentally regulated GTP-binding protein-2 increases bone loss.
Choi et al., Ulsan, South Korea. In Am J Physiol Endocrinol Metab, 2013
The developmentally regulated GTP-binding protein-2 (DRG2) is a novel subclass of GTP-binding proteins.
Efficacy of early treatment on 52 patients with preneoplastic hepatitis B virus-associated hepatocellular carcinoma by compound Phyllanthus Urinaria L.
Tang et al., Shenzhen, China. In Chin J Integr Med, 2013
METHODS: A total of 102 cirrhosis patients with regenerative or dysplastic nodules whose sera were tested positive for at least one of these six proteins (five up-regulated genes URG4, URG7, URG11, URG12 and URG19, and one down-regulated gene DRG2) were assigned randomly to two groups using continual random codes by SPSS software.
SKP1-CULLIN1-F-box (SCF)-mediated DRG2 degradation facilitated chemotherapeutic drugs induced apoptosis in hepatocellular carcinoma cells.
Peng et al., Shanghai, China. In Biochem Biophys Res Commun, 2012
Developmentally regulated GTP-binding protein 2 (DRG2), an evolutionarily conserved member of the DRG subfamily in the GTP-binding protein, is thought to play an essential role in the control of cell growth and differentiation.
Transcription factor Sp1 regulates basal transcription of the human DRG2 gene.
GeneRIF
Park et al., Ulsan, South Korea. In Biochim Biophys Acta, 2011
Basal expression level of DRG2 is regulated by the Sp1 transcription factor.
[Anticancer activities of curcumin on human hepatocarcinoma cell line Sk-hep-1].
Zhang et al., Guangzhou, China. In Zhongguo Zhong Yao Za Zhi, 2010
The effect of curcumin on the expression of anti-apoptosis genes (Survivin and BCl-xL) and drug resistance genes (DRG2 and MDR1) was studied by reverse transcription-polymerase chain reaction (RT-PCR).
Biochemical characterization of Arabidopsis developmentally regulated G-proteins (DRGs).
Botella et al., Australia. In Protein Expr Purif, 2009
The atDRG proteins hydrolyze GTP at a relatively slow rate (0.94x10(-3)min(-1) for DRG1 and 1.36x10(-3)min(-1) for DRG2) that is consistent with their nearest characterized relatives, the Obg subfamily.
Duplication of 17(p11.2p11.2) in a male child with autism and severe language delay.
McInnes et al., New York City, United States. In Am J Med Genet A, 2008
Gene expression analyses revealed increased expression of three candidate genes for the Smith-Magenis neurobehavioral phenotype, RAI1, DRG2, and RASD1, in transformed lymphocytes from Case 81A, suggesting gene dosage effects.
Identification of DRG family regulatory proteins (DFRPs): specific regulation of DRG1 and DRG2.
Inoue et al., Tokyo, Japan. In Genes Cells, 2005
DRG1 and DRG2 comprise a highly conserved subfamily of GTP-binding proteins and are thought to act as critical regulators of cell growth.
NMR solution structure of Cn12, a novel peptide from the Mexican scorpion Centruroides noxius with a typical beta-toxin sequence but with alpha-like physiological activity.
Possani et al., Mexico. In Eur J Biochem, 2004
The amino-acid sequence of Cn12 resembles the beta scorpion toxin class, although patch-clamp experiments showed the induction of supplementary slow inactivation of Na(+) channels in F-11 cells (mouse neuroblastoma N18TG-2 x rat DRG2), which means that it behaves more like an alpha scorpion toxin.
Overexpression of DRG2 increases G2/M phase cells and decreases sensitivity to nocodazole-induced apoptosis.
GeneRIF
Park et al., Ulsan, South Korea. In J Biochem, 2004
overexpression of DRG2 in Jurkat cells affects genes regulating cell-cycle arrest and apoptosis, and that these molecular changes may be important in the growth or differentiation of cells
Overexpression of DRG2 suppresses the growth of Jurkat T cells but does not induce apoptosis.
Park et al., Ulsan, South Korea. In Arch Biochem Biophys, 2004
To investigate the effect of the expression of DRG2 on cell growth, we constructed a human Jurkat-T-cell line that overexpresses DRG2.
Cloning and characterization of Xenopus laevis drg2, a member of the developmentally regulated GTP-binding protein subfamily.
Inoue et al., Tokyo, Japan. In Gene, 2004
DRG2 and DRG1 comprise the DRG subfamily in eucaryotes.
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