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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Kv channel interacting protein 3, calsenilin

DREAM, calsenilin, KChIP3
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, AGE, iMpact, Kv1.4
Papers using DREAM antibodies
The DREAM protein negatively regulates the NMDA receptor through interaction with the NR1 subunit
Naranjo Jose R. et al., In Frontiers in Molecular Neuroscience, 2009
... DREAM transgenic mice were prepared by ...
Papers on DREAM
Zebrafish embryos as a screen for DNA methylation modifications after compound exposure.
van der Ven et al., Bahrain. In Toxicol Appl Pharmacol, Feb 2016
Genome wide locus-specific analysis was performed for BPA exposed embryos using Digital Restriction Enzyme Analysis of Methylation (DREAM), which showed minimal wide scale effects on the genome, whereas potential informative markers were not confirmed by pyrosequencing.
Employment and sick leave in patients with prostate cancer before, during and after radiotherapy.
Petersen et al., Copenhagen, Denmark. In Scand J Urol, Feb 2016
MATERIALS AND METHODS: The Danish DREAM database contains information about social benefits paid to Danish citizens.
Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease.
Mellström et al., In J Clin Invest, Feb 2016
Here, we determined that expression of downstream regulatory element antagonist modulator (DREAM), a multifunctional Ca2+-binding protein, is reduced in murine in vivo and in vitro HD models and in HD patients.
Efficacy of protease inhibitor monotherapy vs. triple therapy: meta-analysis of data from 2303 patients in 13 randomized trials.
Hadacek et al., Madrid, Spain. In Hiv Med, Jan 2016
RESULTS: There were 2303 patients from 13 different randomized clinical trials of darunavir/r monotherapy (n = 784: MONET, MONOI, Monarch and PROTEA), lopinavir/r monotherapy (n = 829: OK pilot, OK-04, KalMo, KALESOLO, KRETA, MOST and DREAM), atazanavir/r monotherapy (n = 103: MODAT), or all three (n = 587: PIVOT).
HPV 16E7 and 48E7 proteins use different mechanisms to target p130 to overcome cell cycle block.
Watson et al., Kuala Lumpur, Malaysia. In Virol J, Dec 2015
P130 is associated with the DREAM (DP, RB-like, E2F and MuvB) complex in G0/G1, which prevents S phase progression by repressing transcription of E2F-regulated genes.
Bevacizumab with or without erlotinib as maintenance therapy in patients with metastatic colorectal cancer (GERCOR DREAM; OPTIMOX3): a randomised, open-label, phase 3 trial.
de Gramont et al., Créteil, France. In Lancet Oncol, Nov 2015
BACKGROUND: The combination of an anti-VEGF or an anti-EGFR-targeted monoclonal antibody with chemotherapy has shown clinical activity in patients with metastatic colorectal cancer.
Elimination of Mother-To-Child Transmission of HIV Infection: The Drug Resource Enhancement against AIDS and Malnutrition Model.
Nielsen-Saines et al., Roma, Italy. In Int J Environ Res Public Health, Oct 2015
The Drug Resource Enhancement against AIDS and Malnutrition Program (DREAM) gathered professionals in the field of Elimination of HIV-Mother-To-Child Transmission (EMTCT) in Maputo in 2013 to discuss obstacles and solutions for the elimination of HIV vertical transmission in sub-Saharan Africa.
Prediction of human population responses to toxic compounds by a collaborative competition.
Saez-Rodriguez et al., Seattle, United States. In Nat Biotechnol, Sep 2015
Here, we report the results from a community-based DREAM challenge to predict toxicities of environmental compounds with potential adverse health effects for human populations.
Evidence for the efficacy and safety of anti-interleukin-5 treatment in the management of refractory eosinophilic asthma.
Pavord et al., Utrecht, Netherlands. In Ther Adv Respir Dis, Aug 2015
An earlier large 616 patient Dose Ranging Efficacy And safety with Mepolizumab in severe asthma (DREAM) study had shown that the only variables associated with treatment efficacy were a prior history of asthma attacks and the peripheral blood eosinophil count.
Combining tumor genome simulation with crowdsourcing to benchmark somatic single-nucleotide-variant detection.
Boutros et al., Santa Cruz, United States. In Nat Methods, Jul 2015
To resolve these issues, we launched the ICGC-TCGA DREAM Somatic Mutation Calling Challenge, a crowdsourced benchmark of somatic mutation detection algorithms.
Mepolizumab for eosinophilic severe asthma: recent studies.
Kariyawasam et al., London, United Kingdom. In Expert Opin Biol Ther, Jun 2015
EXPERT OPINION: This represents an important new treatment option in an area of unmet need, and together with a large dose ranging study (DREAM) published in 2012 form the basis for filing for registration in the USA and Europe.
Crowdsourced analysis of clinical trial data to predict amyotrophic lateral sclerosis progression.
Leitner et al., München, Germany. In Nat Biotechnol, 2015
Here, we report results from the DREAM-Phil Bowen ALS Prediction Prize4Life challenge.
Reverse phase protein arrays in signaling pathways: a data integration perspective.
Huang et al., Houston, United States. In Drug Des Devel Ther, 2014
There also exists a clear need for effective visualization approaches to RPPA-based proteomic results; this was highlighted by the recent challenge, put forth by the HPN-DREAM consortium, to develop visualization methods for a highly complex RPPA dataset involving many cancer cell lines, stimuli, and inhibitors applied over time course.
A community computational challenge to predict the activity of pairs of compounds.
NCI-DREAM Community et al., New York City, United States. In Nat Biotechnol, 2014
The DREAM consortium launched an open challenge to foster the development of in silico methods to computationally rank 91 compound pairs, from the most synergistic to the most antagonistic, based on gene-expression profiles of human B cells treated with individual compounds at multiple time points and concentrations.
[Closed-Loop at night for the treatment of type 1 diabetes].
Kordonouri et al., Hannover, Germany. In Dtsch Med Wochenschr, 2014
In the multinational, multicenter DREAM project patients at a diabetes camp who were treated with an artificial-pancreas system had less nocturnal hypoglycemia and tighter glucose control than when they were treated with a sensor-augmented insulin pump.
Subcellular localization and transcription regulatory potency of KCNIP/Calsenilin/DREAM/KChIP proteins in cultured primary cortical neurons do not provide support for their role in CRE-dependent gene expression.
Timmusk et al., Tallinn, Estonia. In J Neurochem, 2012
This study demonstrated that the KCNIP proteins localize differently when over-expressed in primary cortical neurons.
Ca2+-activated nucleotidase 1, a novel target gene for the transcriptional repressor DREAM (downstream regulatory element antagonist modulator), is involved in protein folding and degradation.
Brini et al., Padova, Italy. In J Biol Chem, 2012
Restoring CANT1 levels in neuroblastoma clones recovered the phenotype, thus confirming a key role of CANT1, and of the regulation of its gene by DREAM, in the control of protein synthesis and degradation
Hyperglycemia induces early upregulation of the calcium sensor KChIP3/DREAM/calsenilin in the rat retina.
Lamas et al., Mexico. In Biochem Biophys Res Commun, 2012
these data suggest an altered expression and function of KChIP3 after streptozotocin induced hyperglycemia that might help explain some pathological alterations in early diabetic retinopathy.
Calsenilin regulates presenilin 1/γ-secretase-mediated N-cadherin ε-cleavage and β-catenin signaling.
Choi et al., Anyang, South Korea. In Faseb J, 2011
expression of calsenilin leads to a disruption of presenilin 1/gamma-secretase-mediated epsilon-cleavage of N-cadherin, which results in the significant accumulation of N-cadherin C-terminal fragment 1
Disruption of repressive p130-DREAM complexes by human papillomavirus 16 E6/E7 oncoproteins is required for cell-cycle progression in cervical cancer cells.
Watson et al., London, United Kingdom. In J Gen Virol, 2011
The results show that continued human papillomavirus 16 E6/E7 expression is necessary in cervical cancer cells to prevent cell-cycle arrest by a repressive p130-DREAM complex.
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