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Dopamine receptor D5

DRD5, D5R
This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: DRD4, DRD2, DAT1, DRD1, CAN
Papers on DRD5
Dopamine and T cells: dopamine receptors and potent effects on T cells, dopamine production in T cells, and abnormalities in the dopaminergic system in T cells in autoimmune, neurological and psychiatric diseases.
Review
New
Levite, Jerusalem, Israel. In Acta Physiol (oxf), Jan 2016
The review covers the following findings: (i) T cells express functional dopamine receptors (DRs) D1R-D5R, but their level and function are dynamic and context-sensitive, (ii) DR membranal protein levels do not necessarily correlate with DR mRNA levels, (iii) different T cell types/subtypes have different DR levels and composition and different responses to dopamine, (iv) autoimmune and pro-inflammatory T cells and T cell leukaemia/lymphoma also express functional DRs, (v) dopamine (~10(-8) M) activates resting/naive Teffs (CD8(+) >>>CD4(+) ), (vi) dopamine affects Th1/Th2/Th17 differentiation, (vii) dopamine inhibits already activated Teffs (i.e.
Differentiation of forebrain and hippocampal dopamine 1-class receptors, D1R and D5R, in spatial learning and memory.
New
Tonegawa et al., Cambridge, United States. In Hippocampus, Jan 2016
Activation of prefrontal cortical (PFC), striatal, and hippocampal dopamine 1-class receptors (D1R and D5R) is necessary for normal spatial information processing.
Dopamine receptor D5 deficiency results in a selective reduction of hippocampal NMDA receptor subunit NR2B expression and impaired memory.
New
Stehberg et al., Santiago, Chile. In Neuropharmacology, Jan 2016
However, the lack of drugs that can discriminate between D1R and D5R has made the pharmacological distinction between the two receptors difficult.
The Synergistic Roles of Cholecystokinin B and Dopamine D5 Receptors on the Regulation of Renal Sodium Excretion.
New
Yang et al., Beijing, China. In Plos One, Dec 2015
Renal dopamine D1-like receptors (D1R and D5R) and the gastrin receptor (CCKBR) are involved in the maintenance of sodium homeostasis.
Postnatal exposure to PFOS, but not PBDE 99, disturb dopaminergic gene transcription in the mouse CNS.
New
Viberg et al., Uppsala, Sweden. In Environ Toxicol Pharmacol, Dec 2015
analyses of brain tissue from mice euthanized 24h post exposure revealed that PFOS affected transcription of Dopamine receptor-D5 (DRD5) in cerebral cortex and Tyrosine hydroxylase (TH) in the hippocampus.
Trans-activation of TRPV1 by D1R in mouse dorsal root ganglion neurons.
New
Oh et al., Seoul, South Korea. In Biochem Biophys Res Commun, Nov 2015
Dopamine is a neurotransmitter that plays important roles in motor control, cognition, and pain modulation in the CNS, and acts via a variety of dopamine receptors (D1R-D5R), a class of GPCRs.
Influence of dopamine receptor gene polymorphisms on circulating T lymphocytes: A pilot study in healthy subjects.
New
Marino et al., Varese, Italy. In Hum Immunol, Oct 2015
We assessed total lymphocytes, CD3+, CD4+ and CD8+ T lymphocytes in peripheral blood of healthy subjects and their association with selected DR gene variants (DRD1 rs4532 and rs686, DRD5 rs6283, DRD2 rs1800497 and rs6277, DRD3 rs6280 and rs1800828, DRD4 rs747302 and 7 48-base pair VNTR).
Expression of somatostatin, dopamine, progesterone and growth hormone receptor mRNA in canine cortisol-secreting adrenocortical tumours.
New
Mol et al., Utrecht, Netherlands. In Vet J, Oct 2015
The relative mRNA expression of growth hormone receptor, progesterone receptor, somatostatin receptors (SSTR1-3) and dopamine receptors (DRD1-2 and DRD5) was evaluated in 36 canine ATs and 15 adrenal glands obtained from healthy dogs.
Lack of association of polymorphisms in six candidate genes in colombian adhd patients.
New
Velez-van-Meerbeke et al., Bogotá, Colombia. In Ann Neurosci, Oct 2015
DRD4, DRD5, SLC6A3 and DBH)and serotoninergic (e.g.HTR1B and SLC6A4) pathways.
Dopamine receptors D3 and D5 regulate CD4(+)T-cell activation and differentiation by modulating ERK activation and cAMP production.
New
Pacheco et al., Santiago, Chile. In J Neuroimmunol, Aug 2015
Since cAMP and ERKs play key roles regulating T-cell physiology, we aim to determine whether cAMP and ERK1/2-phosphorylation are modulated by dopamine receptor 3 (D3R) and D5R, and how this modulation affects CD4(+) T-cell activation and differentiation.
The molecular genetic architecture of attention deficit hyperactivity disorder.
Review
New
Bellgrove et al., Melbourne, Australia. In Mol Psychiatry, Mar 2015
Candidate gene associations of minor effect size have been replicated across a number of genes including SLC6A3, DRD5, DRD4, SLC6A4, LPHN3, SNAP-25, HTR1B, NOS1 and GIT1.
DRD and GRIN2B polymorphisms and their association with the development of impulse control behaviour among Malaysian Parkinson's disease patients.
Mohamed Ibrahim et al., Kuala Selangor, Malaysia. In Bmc Neurol, 2014
METHOD: We used high resolution melt (HRM) analysis to genotype 11 polymorphisms in 5 DRD genes [DRD1 (rs4532, rs4867798 and rs265981), DRD2 (ANKK1 rs1800497, rs104894220 and rs144999500), DRD3 (rs3732783 and rs6280), DRD4 (rs1800443), and DRD5 (rs144132215)] and 1 polymorphism in GRIN2B (rs7301328) in PD patients with (cases, n = 52) and without (controls, n = 39) ICB.
Renal dopamine receptors, oxidative stress, and hypertension.
Review
Armando et al., Baltimore, United States. In Int J Mol Sci, 2012
Lack of any of the five dopamine receptor subtypes (D1R, D2R, D3R, D4R, and D5R) results in hypertension.
Biochemical and genetic analyses of childhood attention deficit/hyperactivity disorder.
Review
Caylak, Çankırı, Turkey. In Am J Med Genet B Neuropsychiatr Genet, 2012
To date, these studies have reported substantial evidence implicating several genes (dopaminergic: DRD4, DAT1, DRD5, COMT; noradrenergic: DBH, ADRA2A; serotonergic: 5-HTT, HTR1B, HTR2A; cholinergic: CHRNA4, and central nervous system development pathway: SNAP25, BDNF) in the etiology of ADHD.
Association study of 45 candidate genes in nicotine dependence in Han Chinese.
GeneRIF
Ma et al., Chengdu, China. In Addict Behav, 2012
For the first time we report a significant association between nicotine dependence and DRD5, NPY1R MAP3K4 single nucleotide polymorphism.
Dopamine D4 and D5 receptor gene variant effects on clozapine response in schizophrenia: replication and exploration.
GeneRIF
Kennedy et al., Toronto, Canada. In Prog Neuropsychopharmacol Biol Psychiatry, 2012
Tests of a DRD5 microsatellite and four DRD5 single nucleotide polymorphism variants do not support a significant deviation from the Hardy-Weinberg equilibrium in either Caucasian or African American patients.
Stimulation of dopamine receptor D5 expressed on dendritic cells potentiates Th17-mediated immunity.
GeneRIF
Pacheco et al., Santiago, Chile. In J Immunol, 2012
By contributing to CD4(+) T cell activation and differentiation to Th17 phenotype, D5R expressed on DCs is able to modulate the development of an autoimmune response in vivo.
The third intracellular loop of D1 and D5 dopaminergic receptors dictates their subtype-specific PKC-induced sensitization and desensitization in a receptor conformation-dependent manner.
GeneRIF
Tiberi et al., Ottawa, Canada. In Cell Signal, 2012
intracellular loop 3 is the critical determinant underlying the subtype-specific regulation of human D5-dopaminergic receptor responsiveness by protein kinase C
Altered mRNA expression of monoaminergic candidate genes in the blood of children with attention deficit hyperactivity disorder and autism spectrum disorder.
GeneRIF
Romanos et al., Würzburg, Germany. In World J Biol Psychiatry, 2011
The concentrations of DRD4-mRNA in the whole blood were significantly lower in ADHD and ASD children (19 of 26 comorbid with ADHD) compared to healthy controls. ASD patients revealed a significantly decreased DRD5 mRNA expression.
Dopamine and renal function and blood pressure regulation.
Review
Jose et al., Washington, D.C., United States. In Compr Physiol, 2011
Dopamine exerts its actions via two families of cell surface receptors, D1-like receptors comprising D1R and D5R, and D2-like receptors comprising D2R, D3R, and D4R, and by interactions with other G protein-coupled receptors.
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