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Dopamine receptor D4

DRD4, dopamine D4 receptor, dopamine receptor D4
This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: DAT1, DRD2, HAD, AGE, Catechol O-Methyltransferase
Papers on DRD4
Activation of dopamine D4 receptors within the anterior cingulate cortex enhances the erroneous expectation of reward on a rat slot machine task.
Winstanley et al., Vancouver, Canada. In Neuropharmacology, Feb 2016
The dopamine D4 receptor critically mediates the erroneous reward expectancy generated on such trials.
The association between the serotonin and dopamine neurotransmitters and personality traits.
Brambilla et al., Italy. In Epidemiol Psychiatr Sci, Feb 2016
In this review, we discuss the impact of two of the most frequently studied genetic polymorphisms on personality in healthy subjects, the 5-HTT polymorphism of the serotonin transporter and the DRD2/DRD4 polymorphisms of the D2/D4 dopamine's receptors.
Effect of salinity on regulation mechanism of neuroendocrine-immunoregulatory network in Litopenaeus vannamei.
Miao et al., Qingdao, China. In Fish Shellfish Immunol, Feb 2016
The gene expression of biogenic amine receptors showed that dopamine receptor D4 and α2 adrenergic receptor in lower salinity groups decreased significantly within 12h, whereas the 5-HT7 receptor significantly increased within 1d.
Mesocorticolimbic dopamine functioning in primary psychopathy: A source of within-group heterogeneity.
Derksen et al., Nijmegen, Netherlands. In Psychiatry Res, Nov 2015
As such, the goal of this review is to examine which specific alterations in the meso-cortico-limbic DA system and corresponding genes (e.g., TH, DAT, COMT, DRD2, DRD4) might bias development towards a more controlled or disinhibited expression of primary psychopathy.
Addiction pharmacogenetics: a systematic review of the genetic variation of the dopaminergic system.
Nielsen et al., Houston, United States. In Psychiatr Genet, Oct 2015
Polymorphisms of the DRD2, ANKK1, DAT1, DBH, and DRD4 genes have been found to moderate the effects of pharmacotherapy of alcohol, opioid, and cocaine use disorders.
The magnificent seven: A quantitative review of dopamine receptor d4 and its association with child behavior.
van IJzendoorn et al., Rotterdam, Netherlands. In Neurosci Biobehav Rev, Oct 2015
A large volume of behavioral research has explored the variable number of tandem repeat (VNTR) polymorphism on the dopamine receptor D4 gene (DRD4).
Genetic association studies of obesity in Africa: a systematic review.
Kengne et al., Cape Town, South Africa. In Obes Rev, Mar 2015
Polymorphisms in genes such as ACE, ADIPOQ, ADRB2, AGRP, AR, CAPN10, CD36, C7orf31, DRD4, FTO, MC3R, MC4R, SGIP1 and LEP were found to be associated with various measures of obesity.
KLHL12 Promotes Non-Lysine Ubiquitination of the Dopamine Receptors D4.2 and D4.4, but Not of the ADHD-Associated D4.7 Variant.
Van Craenenbroeck et al., Gent, Belgium. In Plos One, 2014
DOPAMINE D4 RECEPTOR POLYMORPHISM: The dopamine D4 receptor has an important polymorphism in its third intracellular loop that is intensively studied and has been associated with several abnormal conditions, among others, attention deficit hyperactivity disorder.
Pharmacogenetics and antipsychotic treatment response.
Suturkova et al., Скопје, Macedonia. In Prilozi, 2014
It highlights the most important findings about the impact of functional polymorphisms in genes coding the CYP450 metabolizing enzymes, ABCB1 transporter gene, dopaminergic and serotonergic drug targets (DRD2, DRD3, DRD4, 5-HT1, 5HT-2A, 5HT-2C, 5HT6) as well as genes responsible for metabolism of neurotransmitters and G signalling pathways (5-HTTLPR, BDNF, COMT, RGS4) and points their role as potential biomarkers in everyday clinical practice.
Aggression, digit ratio, and variation in the androgen receptor, serotonin transporter, and dopamine D4 receptor genes in African foragers: the Hadza.
Ryskov et al., Moscow, Russia. In Behav Genet, 2012
This is first study on variation in aggression, digit ratio (ratio between the second and fourth digits, 2D:4D), directional asymmetry in 2D:4D (D(R-L)) and polymorphisms of the AR, DRD4, and 5-HTTL genes in simple hunter-gatherers, the Hadza of Tanzania
Lack of association between dopamine receptor D4 variable numbers of tandem repeats gene polymorphism and smoking.
Pivac et al., Zagreb, Croatia. In Neurosci Lett, 2012
The results of this study failed to confirm the hypothesis that long allele of the DRD4 VNTR is associated with smoking status in Caucasian subjects.
DRD4 VNTR polymorphism and age at onset of severe mental illnesses.
Kennedy et al., Toronto, Canada. In Neurosci Lett, 2012
Our results showed an interaction between sex and DRD4 genotypes among schizophrenia patients (n=203, beta=.213, p=.017).
A family-based association study of dopamine receptor D4 and mental retardation in Qinba region of China.
Gao et al., Xi'an, China. In Neurosci Lett, 2012
Therefore, the present study suggested that the genetic variants of DRD4 gene may play an important role in human MR
Dopaminergic polymorphisms associated with time-on-task declines and fatigue in the Psychomotor Vigilance Test.
Kwok et al., Singapore, Singapore. In Plos One, 2011
the exon III DRD4 48 bp VNTR of the dopamine receptor gene DRD4 was associated with subjective decreases in energy
Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.
Bertram et al., United States. In Nat Genet, 2008
Across 118 meta-analyses, a total of 24 genetic variants in 16 different genes (APOE, COMT, DAO, DRD1, DRD2, DRD4, DTNBP1, GABRB2, GRIN2B, HP, IL1B, MTHFR, PLXNA2, SLC6A4, TP53 and TPH1) showed nominally significant effects with average summary odds ratios of approximately 1.23.
Additional evidence for an association between the dopamine D4 receptor (D4DR) exon III seven-repeat allele and substance abuse in opioid dependent subjects: relationship of treatment retention to genotype and personality.
Ebstein et al., Jerusalem, Israel. In Addict Biol, 1998
The long form of the dopamine D4 receptor (D4DR) exon III repeat polymorphism has been linked in some but not all studies to impulsive, extravagant and novelty-seeking personality traits that are prominent in affiliated behaviours such as attention deficit disorder and substance abuse.
Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine.
Grandy et al., Buenos Aires, Argentina. In Cell, 1997
The human dopamine D4 receptor (D4R) has received considerable attention because of its high affinity for the atypical antipsychotic clozapine and the unusually polymorphic nature of its gene.
Dopamine D4 receptors elevated in schizophrenia.
Van Tol et al., Toronto, Canada. In Nature, 1993
The dopamine D4 receptor gene has not yet been excluded in schizophrenia because the 21 gene variants of D4 have not yet been tested.
Multiple dopamine D4 receptor variants in the human population.
Jovanovic et al., Toronto, Canada. In Nature, 1992
The dopamine D4 receptor structurally and pharmacologically resembles the dopamine D2 and D3 receptors.
Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine.
Civelli et al., Toronto, Canada. In Nature, 1991
Dopamine receptors belong to the family of G protein-coupled receptors.
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