Mechanisms of the psychostimulant effects of caffeine: implications for substance use disorders.
Baltimore, United States. In Psychopharmacology (berl), Feb 2016
OBJECTIVES: A model that considers the striatal adenosine A2A-dopamine D2 receptor heteromer as a key modulator of dopamine-dependent striatal functions (reward-oriented behavior and learning of stimulus-reward and reward-response associations) is introduced, which should explain most of the psychomotor and reinforcing effects of caffeine.
Biological insights from 108 schizophrenia-associated genetic loci.
In Nature, 2014
Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses.