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Dopamine receptor D1

DRD1, dopamine receptor D1
This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: DRD2, Essential Tremor, DRD4, HAD, DRD5
Papers on DRD1
Developmental neurogenetics and multimodal neuroimaging of sex differences in autism.
GENDAAR Research Consortium et al., Los Angeles, United States. In Brain Imaging Behav, Feb 2016
DRD1, NLGN3, MAOA, and SHANK1 deletion have been discovered in ASD.
When the party is over: depressive-like states in rats following termination of cortical D1 receptor overexpression.
Andersen et al., Belmont, United States. In Psychopharmacology (berl), Feb 2016
METHODS: An inducible (Tet.On), lentiviral vector was used to manipulate the expression of the DRD1 gene in glutamate neurons within the prefrontal cortex in male, adult rats.
Dopamine receptor D5 deficiency results in a selective reduction of hippocampal NMDA receptor subunit NR2B expression and impaired memory.
Stehberg et al., Santiago, Chile. In Neuropharmacology, Jan 2016
Analyses using genetic approaches have determined the relative contribution of dopamine receptor D1 (D1R) in cognitive tasks.
Association between GRK4 and DRD1 gene polymorphisms and hypertension: a meta-analysis.
Yang et al., Shenyang, China. In Clin Interv Aging, Dec 2015
The role of GRK4 and DRD1 genes in hypertension remains controversial.
A Mutation in Plant-Specific SWI2/SNF2-Like Chromatin-Remodeling Proteins, DRD1 and DDM1, Delays Leaf Senescence in Arabidopsis thaliana.
Kim et al., South Korea. In Plos One, Dec 2015
Therefore, we chose to examine the functions of DRD1, a SWI2/SNF2 chromatin remodeling protein, in epigenetic regulation of leaf senescence, particularly because drd1-6 mutants exhibited a delayed leaf senescence phenotype.
Hippocampal Dopamine/DRD1 Signaling Dependent on the Ghrelin Receptor.
Smith et al., Jupiter, United States. In Cell, Dec 2015
The ghrelin receptor (GHSR1a) and dopamine receptor-1 (DRD1) are coexpressed in hippocampal neurons, yet ghrelin is undetectable in the hippocampus; therefore, we sought a function for apo-GHSR1a.
Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome.
Zhou et al., Hefei, China. In Cell, Feb 2015
Here, we report that the neurotransmitter dopamine (DA) inhibits NLRP3 inflammasome activation via dopamine D1 receptor (DRD1).
Genetics of impulse control disorders in Parkinson's disease.
Corvol et al., Paris, France. In J Neural Transm, 2013
Recent genetic studies have investigated associations between ICD and polymorphisms of genes involved in the dopamine metabolism pathway (COMT, DAT), dopamine receptors (DRD1, DRD2, DRD3, DRD4), serotonin receptors and its transporter (HTR2A, 5HTT), and glutamate receptors (GRIN2B).
The Arabidopsis nucleosome remodeler DDM1 allows DNA methyltransferases to access H1-containing heterochromatin.
Zilberman et al., Berkeley, United States. In Cell, 2013
RdDM is instead inhibited by heterochromatin and absolutely requires the nucleosome remodeler DRD1.
DDR complex facilitates global association of RNA polymerase V to promoters and evolutionarily young transposons.
Jacobsen et al., Los Angeles, United States. In Nat Struct Mol Biol, 2012
Genome-wide chromatin association of NRPE1 is dependent on all members of a putative chromatin-remodeling complex termed DDR, which includes the proteins DRD1, DMS3 and RDM1.
A comparison of striatal-dependent behaviors in wild-type and hemizygous Drd1a and Drd2 BAC transgenic mice.
Kreitzer et al., San Francisco, United States. In J Neurosci, 2012
Comparison of behavioral studies in wild-type C57BL/6 mice and hemizygous Drd1a mice backcrossed into C57BL/6 background finds open-field locomotion, conditioned place preference, and avoidance learning are indistinguishable in the transgenic lines.
DRD1 associations with smoking abstinence across slow and normal nicotine metabolizers.
Conti et al., Los Angeles, United States. In Pharmacogenet Genomics, 2012
the role of DRD1 in nicotine dependence, and identify genetic and nicotine metabolism profiles that may interact to impact nicotine dependence.
Aging-related increases in behavioral variability: relations to losses of dopamine D1 receptors.
Bäckman et al., Victoria, Canada. In J Neurosci, 2012
the association between age and IIV in the interference condition was linked to D1 receptor losses in task-relevant brain regions.
Generational association studies of dopaminergic genes in reward deficiency syndrome (RDS) subjects: selecting appropriate phenotypes for reward dependence behaviors.
Bailey et al., Gainesville, United States. In Int J Environ Res Public Health, 2011
evaluated the potential association of four variants of dopaminergic candidate genes in RDS (dopamine D1 receptor gene [DRD1]; dopamine D2 receptor gene [DRD2]; dopamine transporter gene [DAT1]; dopamine beta-hydroxylase gene [DBH]).
[Searching for Tourette's syndrome gene. Part 2. Patient's genome variability].
Rajewski et al., Poznań, Poland. In Postepy Hig Med Dosw (online), 2011
The distribution of single nucleotide polymorphisms (SNPs) was examined in at least 14 candidate genes (DRD1, DRD2, DRD3, DRD4, DAT1, MAOA, 5HTR2A, 5HTR3A, TDO2, CNR1, HLA-DRB, IL1RA, MOG, and SGCE) using a case-control genetic association analysis.
Genetic and environmental influences on psychiatric comorbidity: a systematic review.
Galea et al., New York City, United States. In J Affect Disord, 2010
A range of candidate genes, such as 5HTTLPR, MAOA, and DRD1-DRD4, as well as others implicated in the central nervous system, has been implicated in psychiatric comorbidity.
Investigation of dopamine receptors in susceptibility to behavioural and psychological symptoms in Alzheimer's disease.
Lendon et al., Brisbane, Australia. In Int J Geriatr Psychiatry, 2009
Polymorphisms within dopamine receptors DRD1, DRD2, DRD3 and DRD4 have previously been investigated in a few interesting studies that are reviewed here and extended using our patient cohort.
Noncoding transcription by RNA polymerase Pol IVb/Pol V mediates transcriptional silencing of overlapping and adjacent genes.
Pikaard et al., Saint Louis, United States. In Cell, 2008
Pol IVb/Pol V function provides a solution to a paradox of epigenetic control: the need for transcription in order to transcriptionally silence the same region
Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.
Bertram et al., United States. In Nat Genet, 2008
Across 118 meta-analyses, a total of 24 genetic variants in 16 different genes (APOE, COMT, DAO, DRD1, DRD2, DRD4, DTNBP1, GABRB2, GRIN2B, HP, IL1B, MTHFR, PLXNA2, SLC6A4, TP53 and TPH1) showed nominally significant effects with average summary odds ratios of approximately 1.23.
A Classic Innate Behavior, Sodium Appetite, Is Driven by Hypothalamic Gene-Regulatory Programs Previously Linked to Addiction and Reward
Liedtke, Boca Raton, United States. In Unknown Journal, 0001
Furthermore, we were able to attenuate sodium intake behavior of sodium appetite by application of antagonists of dopamine receptor-1 (DRD1) both systemically as well as by microinjection into the lateral hypothalamus.
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