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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Serine/threonine kinase 17b

DRAK2, Stk17b
over-expression causes apoptosis-like cell death which is dependent on the kinase activity [RGD, Feb 2006] (from NCBI)
Papers on DRAK2
Protein kinase D orchestrates the activation of DRAK2 in response to TCR-induced Ca2+ influx and mitochondrial reactive oxygen generation.
GeneRIF
Walsh et al., Irvine, United States. In J Immunol, 2011
DRAK2 and protein kinase D form a novel signaling module that controls calcium homeostasis following T cell activation.
Regulation of the apoptosis-inducing kinase DRAK2 by cyclooxygenase-2 in colorectal cancer.
GeneRIF
Fitzgerald et al., Dublin, Ireland. In Br J Cancer, 2009
Regulation of the apoptosis-inducing kinase DRAK2 by cyclooxygenase-2 in colorectal cancer.
Altered thymic selection and increased autoimmunity caused by ectopic expression of DRAK2 during T cell development.
GeneRIF
Walsh et al., Irvine, United States. In J Immunol, 2009
Strong suppression of T cell receptor signals during thymic selection caused by ectopic DRAK2 expression in a DRAK2 transgenic mouse model of autoimmune encephalomyelitis alters the responsiveness of peripheral T cells.
Drak2 is upstream of p70S6 kinase: its implication in cytokine-induced islet apoptosis, diabetes, and islet transplantation.
GeneRIF
Wu et al., Montréal, Canada. In J Immunol, 2009
p70S6 kinase was a bona fide Drak2 substrate
Enhanced T cell apoptosis within Drak2-deficient mice promotes resistance to autoimmunity.
GeneRIF
Walsh et al., Irvine, United States. In J Immunol, 2009
DRAK2 blockade may lead to permanent autoimmune T cell destruction via intrinsic apoptosis pathways.
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