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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Serine/threonine kinase 17b

DRAK2, Stk17b
over-expression causes apoptosis-like cell death which is dependent on the kinase activity [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: amylin, CAN, V1a, CD8, DAPK
Papers on DRAK2
Synthesis and structure-activity relationship studies of 2-(1,3,4-oxadiazole-2(3H)-thione)-3-amino-5-arylthieno[2,3-b]pyridines as inhibitors of DRAK2.
Herdewijn et al., Leuven, Belgium. In Chemmedchem, 2014
In recent years, DAPK-related apoptosis-inducing protein kinase 2 (DRAK2) has emerged as a promising target for the treatment of a variety of autoimmune diseases and for the prevention of graft rejection after organ transplantation.
Discovery of dual death-associated protein related apoptosis inducing protein kinase 1 and 2 inhibitors by a scaffold hopping approach.
Herdewijn et al., Leuven, Belgium. In J Med Chem, 2014
DRAK2 emerged as a promising drug target for the treatment of autoimmune diseases and to prevent graft rejection after organ transplantation.
A novel DRAK inhibitor, SC82510, promotes axon branching of adult sensory neurons in vitro.
Klimaschewski et al., Innsbruck, Austria. In Neurochem Res, 2014
Recently, a new potent protein kinase inhibitor, SC82510, was identified acting on DRAK2 and stimulating axon outgrowth at low concentrations.
Upregulation of T-cell factor-4 isoform-responsive target genes in hepatocellular carcinoma.
Kim et al., Providence, United States. In Liver Int, 2013
It was observed that 13 genes (CLDN2, STK17B, SPP1, AXIN2, WISP2, MMP7, IRS1, ANXA1, CAMK2N1, ASPH, GPR56, CD24 and JAG1) activated by TCF-4J isoform in HCC cells, were also upregulated in HCC tumours compared with adjacent peritumour tissue; more importantly, 10 genes exhibited a significant correlation with the TCF-4J expression level in tumour.
The MYB oncogene can suppress apoptosis in acute myeloid leukemia cells by transcriptional repression of DRAK2 expression.
Gonda et al., Brisbane, Australia. In Leuk Res, 2013
This was accompanied by up-regulation of the pro-apoptotic gene DRAK2 and stimulation of caspase-9 activity.
An epistatic interaction between the PAX8 and STK17B genes in papillary thyroid cancer susceptibility.
Robledo et al., Madrid, Spain. In Plos One, 2012
In addition to identifying the involvement of TSHR variation in classic PTC, our pioneer study of epistasis revealed a significant interaction between variants in STK17B and PAX8.
Modulation of T Cell Metabolism and Function through Calcium Signaling.
Walsh et al., Irvine, United States. In Front Immunol, 2012
As a target of mitochondrial ROS and Ca(2+) regulation, we describe the involvement of the serine/threonine kinase DRAK2 in the context of these processes.
DRAK2 participates in a negative feedback loop to control TGF-β/Smads signaling by binding to type I TGF-β receptor.
Kim et al., Seoul, South Korea. In Cell Rep, 2012
Here, we demonstrate that DRAK2 serves as a TGF-β1-inducible antagonist of TGF-β signaling.
Loss of DRAK2 signaling enhances allogeneic transplant survival by limiting effector and memory T cell responses.
Walsh et al., Irvine, United States. In Am J Transplant, 2012
Here, we demonstrate that loss of DRAK2 signaling significantly promotes the acceptance of allogeneic engraftment in two separate transplant models without promoting generalized immunosuppression.
Translocation t(11;14) (q13;q32) and genomic imbalances in multi-ethnic multiple myeloma patients: a Malaysian study.
Zakaria et al., Kuala Lumpur, Malaysia. In Hematol Rep, 2012
Copy number variations at genetic loci that contain NAMPT, IVNS1ABP and STK17B genes are new findings that have not previously been reported in myeloma patients.
Effects of low-level laser irradiation on mesenchymal stem cell proliferation: a microarray analysis.
Zhang et al., Beijing, China. In Lasers Med Sci, 2012
Real-time PCR confirmed that the expression levels of v-akt murine thymoma viral oncogene homolog 1 (Akt1), the cyclin D1 gene (Ccnd1) and the phosphatidylinositol 3-kinase, catalytic alpha polypeptide gene (Pik3ca) were upregulated after LLLI, whereas those of protein tyrosine phosphatase non-receptor type 6 (Ptpn6) and serine/threonine kinase 17b (Stk17b) were downregulated.
Global methylation patterns in idiopathic pulmonary fibrosis.
Kaminski et al., Pittsburgh, United States. In Plos One, 2011
The expression of three genes (STK17B, STK3 and HIST1H2AH) with hypomethylated promoters was increased in IPF lungs.
Cytoskeletal protein kinases: titin and its relations in mechanosensing.
Gautel, London, United Kingdom. In Pflugers Arch, 2011
Similar to other MLCK-like kinases like DRAK2 and DAPK1, TK is linked to protein turnover regulation via the autophagy/lysosomal system, suggesting the MLCK-like kinases have common functions beyond contraction regulation.
Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells.
Spinella et al., United States. In J Biol Chem, 2011
STK17A is not present in the mouse genome, but the closely related gene STK17B is induced with cisplatin in mouse NIH3T3 cells, although this induction is p53-independent.
Protein kinase D orchestrates the activation of DRAK2 in response to TCR-induced Ca2+ influx and mitochondrial reactive oxygen generation.
Walsh et al., Irvine, United States. In J Immunol, 2011
DRAK2 and protein kinase D form a novel signaling module that controls calcium homeostasis following T cell activation.
Regulation of the apoptosis-inducing kinase DRAK2 by cyclooxygenase-2 in colorectal cancer.
Fitzgerald et al., Dublin, Ireland. In Br J Cancer, 2009
Regulation of the apoptosis-inducing kinase DRAK2 by cyclooxygenase-2 in colorectal cancer.
Altered thymic selection and increased autoimmunity caused by ectopic expression of DRAK2 during T cell development.
Walsh et al., Irvine, United States. In J Immunol, 2009
Strong suppression of T cell receptor signals during thymic selection caused by ectopic DRAK2 expression in a DRAK2 transgenic mouse model of autoimmune encephalomyelitis alters the responsiveness of peripheral T cells.
Drak2 is upstream of p70S6 kinase: its implication in cytokine-induced islet apoptosis, diabetes, and islet transplantation.
Wu et al., Montréal, Canada. In J Immunol, 2009
p70S6 kinase was a bona fide Drak2 substrate
Enhanced T cell apoptosis within Drak2-deficient mice promotes resistance to autoimmunity.
Walsh et al., Irvine, United States. In J Immunol, 2009
DRAK2 blockade may lead to permanent autoimmune T cell destruction via intrinsic apoptosis pathways.
A deficiency in Drak2 results in a T cell hypersensitivity and an unexpected resistance to autoimmunity.
Hedrick et al., San Diego, United States. In Immunity, 2004
T cells from Drak2(-/-) mice exhibited enhanced sensitivity to T cell receptor-mediated stimulation with a reduced requirement for costimulation
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