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Serine/threonine kinase 17a

DRAK1, STK17A, Death-associated protein kinase-related
This gene is a member of the DAP kinase-related apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: CAN, OUT, p53, amylin, DRAK2
Papers on DRAK1
Cytoplasmic DRAK1 overexpressed in head and neck cancers inhibits TGF-β1 tumor suppressor activity by binding to Smad3 to interrupt its complex formation with Smad4.
Kim et al., Seoul, South Korea. In Oncogene, Oct 2015
In the present study, we describe the role of DRAK1 (death-associated protein kinase-related apoptosis-inducing kinase 1) as a novel negative regulator of the transforming growth factor-β (TGF-β) tumor suppressor signaling pathway for the first time in human HNSCC cells.
Abnormal Localization of STK17A in Bile Canaliculi in Liver Allografts: An Early Sign of Chronic Rejection.
Miyagawa-Hayashino et al., Kyoto, Japan. In Plos One, 2014
The biological significance of STK17A, a serine/threonine kinase, in the liver is not known.
Discovery of dual death-associated protein related apoptosis inducing protein kinase 1 and 2 inhibitors by a scaffold hopping approach.
Herdewijn et al., Leuven, Belgium. In J Med Chem, 2014
Moreover, this compound also behaves as a functional inhibitor of DRAK2 enzymatic activity, displaying an IC50 value of 0.82 μM, although lacking selectivity, when tested against DRAK1.
Expression profiling of cervical cancers in Indian women at different stages to identify gene signatures during progression of the disease.
Mulherkar et al., Mumbai, India. In Cancer Med, 2013
Additionally, we identified candidate biomarkers of disease progression such as SPP1, proliferating cell nuclear antigen (PCNA), STK17A, and DUSP1 among others that were validated by quantitative real-time polymerase chain reaction (qRT-PCR) in the samples used for microarray studies as well in an independent set of 34 additional samples.
Polymorphisms in STK17A gene are associated with systemic lupus erythematosus and its clinical manifestations.
Sandrin-Garcia et al., Recife, Brazil. In Gene, 2013
In this regard, we investigated whether polymorphisms in STK17A, a DNA repair related gene, encoding for serine/threonine-protein kinase 17A, are associated with SLE susceptibility.
Serine/threonine kinase 17A is a novel candidate for therapeutic targeting in glioblastoma.
Spinella et al., United States. In Plos One, 2012
STK17A is a relatively uncharacterized member of the death-associated protein family of serine/threonine kinases which have previously been associated with cell death and apoptosis.
Kinase inhibition by the Jamaican ball moss, Tillandsia recurvata L.
Bryant et al., Kingston, Jamaica. In Anticancer Res, 2012
Out of the 40 kinases, the Jamaican ball moss selectively inhibited 5 (CSNK2A2, MEK5, GAK, FLT and DRAK1) and obtained Kd(50)s were below 20 μg/ml.
Survivin selective inhibitor YM155 induce apoptosis in SK-NEP-1 Wilms tumor cells.
Pan et al., Suzhou, China. In Bmc Cancer, 2011
IPA analysis also showed top molecules up-regulated were BBC3, BIRC3, BIRC8, BNIP1, CASP7, CASP9, CD5, CDKN1A, CEBPG and COL4A3, top molecules down-regulated were ZNF443, UTP11L, TP73, TNFSF10, TNFRSF1B, TNFRSF25, TIAF1, STK17A, SST and SPP1, upstream regulator were NR3C1, TP53, dexamethasone , TNF and Akt.
High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors.
Gray et al., Boston, United States. In Chem Biol, 2011
In addition, we identified potent inhibitors for so far unexplored kinases such as DRAK1, HIPK2, and DCAMKL1 that await further evaluation.
Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells.
Spinella et al., United States. In J Biol Chem, 2011
identified STK17A as a novel direct target of p53 and a modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells.
Enhancing apoptosis and overcoming resistance of gemcitabine in pancreatic cancer with bortezomib: a role of death-associated protein kinase-related apoptosis-inducing protein kinase 1.
Wu et al., China. In Tumori, 2009
AIMS AND BACKGROUND: To investigate the role of the apoptosis gene, DAP (death-associated protein) kinase-related apoptosis-inducing protein kinase 1 (DRAK1), which is involved in enhancing cell sensitivity and overcoming cell resistance to gemcitabine in pancreatic cancer cells by the proteasome inhibitor bortezomib.
Drak2 contributes to West Nile virus entry into the brain and lethal encephalitis.
Wang et al., Fort Collins, United States. In J Immunol, 2008
Death-associated protein kinase-related apoptosis-inducing kinase-2 (Drak2), a member of the death-associated protein family of serine/threonine kinases, is specifically expressed in T and B cells.
Gene expression analysis of major lineage-defining factors in human bone marrow cells: effect of aging, gender, and age-related disorders.
Uemura et al., Tsukuba, Japan. In J Orthop Res, 2008
Two apoptosis-related genes, bcl-2 and drak1, were studied.
Characterization of homozygous deletions in laryngeal squamous cell carcinoma cell lines.
Szyfter et al., Poznań, Poland. In Cancer Genet Cytogenet, 2008
Among others, these homozygous deletions affected the tumor suppressor gene CDKN2A and the apoptosis-inducing STK17A gene.
Establishment and gene analysis of an oxaliplatin-resistant colon cancer cell line THC8307/L-OHP.
Li et al., Tianjin, China. In Anticancer Drugs, 2007
Proapoptotic genes such as STK17A and BNIP3 were significantly downregulated, whereas the genes PSAP and GDIA1, which were involved in antiapoptosis, were overexpressed.
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