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Solute carrier family 26, member 3

DRA, SLC26A3
The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea. [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: HLA-DRA, MHC, CAN, ACID, HAD
Papers on DRA
A systematic molecular dynamics approach to the structural characterization of amyloid aggregation propensity of β2-microglobulin mutant D76N.
New
R et al., Vellore, India. In Mol Biosyst, Feb 2016
UNASSIGNED: Beta-2 microglobulin (β2m) is an amyloidogenic protein belongs to the immunoglobulin superfamily, responsible for the dialysis-related amyloidosis (DRA).
Genetic variants associated with drugs-induced immediate hypersensitivity reactions: a PRISMA-compliant systematic review.
Review
New
Task force “Genetic predictors of drug hypersensitivity” of the European Network on Drug Allergy (ENDA) of EAACI. et al., Vandœuvre-lès-Nancy, France. In Allergy, Jan 2016
Genes involved in IR to betalactams belonged to HLA type 2 antigen processing, IgE-production, atopy and inflammation, including 4 genes validated by replications, HLA-DRA, ILR4, NOD2 and LGALS3.
AMP18 interacts with the anion exchanger SLC26A3 and enhances its expression in gastric cancer cells.
New
Arcari et al., Napoli, Italy. In Biochimie, Jan 2016
The pool of interacting proteins contained SLC26A3, a protein expressed in the apical membrane of intestinal epithelial cells, supposed to play a critical role in Cl(-) absorption and fluid homeostasis.
Clinical expression of facioscapulohumeral muscular dystrophy in carriers of 1-3 D4Z4 reduced alleles: experience of the FSHD Italian National Registry.
New
Tupler et al., Reggio nell'Emilia, Italy. In Bmj Open, Dec 2015
Particularly severe FSHD cases, characterised by an infantile onset and presence of additional extra-muscular features, have been associated with the shortest D4Z4 reduced alleles with 1-3 repeats (1-3 DRA).
Sensing viral RNAs by Dicer/RIG-I like ATPases across species.
Review
New
Meignin et al., Strasbourg, France. In Curr Opin Immunol, Feb 2015
This helicase, also known as a duplex RNA activated ATPase, or DRA domain, plays an important role in viral RNA sensing.
Network-assisted analysis of primary Sjögren's syndrome GWAS data in Han Chinese.
Wang et al., Beijing, China. In Sci Rep, 2014
Of these pSS candidates, 14 genes had been reported to be associated with any of pSS, RA, and SLE, including STAT4, GTF2I, HLA-DPB1, HLA-DRB1, PTTG1, HLA-DQB1, MBL2, TAP2, CFLAR, NFKBIE, HLA-DRA, APOM, HLA-DQA2 and NOTCH4.
Knowledge-based analysis of genetic associations of rheumatoid arthritis to inform studies searching for pleiotropic genes: a literature review and network analysis.
Review
Rao et al., Beijing, China. In Arthritis Res Ther, 2014
RESULTS: In total, we extracted 116 potential functional pleiotropic genes for RA and eight other diseases, including five hub pleiotropic genes, BTNL2, HLA-DRA, NOTCH4, TNXB, and C6orf10, where BTNL2, NOTCH4, and C6orf10 are novel pleiotropic genes identified by our analysis.
Polymorphism of Alcohol Metabolizing Gene ADH3 Predisposes to Development of Alcoholic Pancreatitis in North Indian Population.
Choudhuri et al., New York City, United States. In Front Mol Biosci, 2014
ALDH2 gene was monomorphic in our population, and the frequencies for CYP2E1 intron 6 Dra I polymorphism were comparable in all the four groups.
SLC26 anion exchangers in uterine epithelial cells and spermatozoa: clues from the past and hints to the future.
Review
Sun et al., Hong Kong, Hong Kong. In Cell Biol Int, 2014
The solute carrier 26 (SLC26) family emerges as a distinct class of anion transporters with its members SLC26A3 (Slc26a3) and SLC26A6 (Slc26a6) reported to be electrogenic Cl(-)/HCO3(-) exchangers.
SLC26 Cl-/HCO3- exchangers in the kidney: roles in health and disease.
Review
Soleimani, Cincinnati, United States. In Kidney Int, 2013
These include SLC26A3, A4, A6, A7, A9, and A11, which are expressed in the kidney except for SLC26A3 (DRA), which is predominantly expressed in the intestine.
Transgenic expression and genetic variation of Lmf1 affect LPL activity in mice and humans.
GeneRIF
Péterfy et al., Los Angeles, United States. In Arterioscler Thromb Vasc Biol, 2012
variation in Lmf1 expression is a posttranslational determinant of LPL activity.
Role of N-glycosylation in cell surface expression and protection against proteolysis of the intestinal anion exchanger SLC26A3.
GeneRIF
Yamashita et al., Shizuoka, Japan. In Am J Physiol Cell Physiol, 2012
these data indicate that N-glycosylation of SLC26A3 is important for cell surface expression and for protection from proteolytic degradation that may contribute to the understanding of pathogenesis of congenital disorders of glycosylation.
Single-cell dissection of transcriptional heterogeneity in human colon tumors.
Impact
Quake et al., Stanford, United States. In Nat Biotechnol, 2011
We develop two-gene classifier systems (KRT20 versus CA1, MS4A12, CD177, SLC26A3) that predict clinical outcomes with hazard ratios superior to those of pathological grade and comparable to those of microarray-derived multigene expression signatures.
Update on SLC26A3 mutations in congenital chloride diarrhea.
Review
GeneRIF
Kere et al., Helsinki, Finland. In Hum Mutat, 2011
This review summarizes the current knowledge of SLC26A3 mutations and polymorphisms in congenital chloride diarrhea. [Review]
Significance of molecular testing for congenital chloride diarrhea.
GeneRIF
Janecke et al., Innsbruck, Austria. In J Pediatr Gastroenterol Nutr, 2011
Data from pediatric patients with congenital chloride diarrhea identifies 7 novel mutations in SLC26A3, including 3 missense changes of highly conserved residues.
Lipase maturation factor 1 is required for endothelial lipase activity.
GeneRIF
Péterfy et al., Los Angeles, United States. In J Lipid Res, 2011
Lipase maturation factor 1 (Lmf1) is required for endothelial lipase activity. Mutations in Lmf1 result in severe hypertriglyceridemia in mice as well as in human subjects.
Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease.
Impact
Payami et al., Albany, United States. In Nat Genet, 2010
The association peak we found was at rs3129882, a noncoding variant in HLA-DRA.
A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.
Impact
GeneRIF
Kubo et al., Yokohama, Japan. In Nat Genet, 2009
glycoprotein gene SLC26A3 new susceptibility loci for ulcerative colitis in the Japanese population.
Risk alleles for multiple sclerosis identified by a genomewide study.
Impact
Hauser et al., Boston, United States. In N Engl J Med, 2007
Of these SNPs, two within the interleukin-2 receptor alpha gene (IL2RA) were strongly associated with multiple sclerosis (P=2.96x10(-8)), as were a nonsynonymous SNP in the interleukin-7 receptor alpha gene (IL7RA) (P=2.94x10(-7)) and multiple SNPs in the HLA-DRA locus (P=8.94x10(-81)).
Gating of CFTR by the STAS domain of SLC26 transporters.
Impact
Muallem et al., Dallas, United States. In Nat Cell Biol, 2004
We report here a reciprocal regulatory interaction between the SLC26T DRA, SLC26A6 and CFTR.
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