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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Tumor necrosis factor receptor superfamily, member 21

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB and MAPK8/JNK, and induce cell apoptosis. Through its death domain, this receptor interacts with TRADD protein, which is known to serve as an adaptor that mediates signal transduction of TNF-receptors. Knockout studies in mice suggested that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: DRB1, DR3, DR4, HAD, CAN
Papers on DR6
A Puckered Singlet Cyclopentane-1,3-diyl: Detection of the Third Isomer in Homolysis.
Adam et al., Hiroshima, Japan. In Chemistry, Feb 2016
UNASSIGNED: In the photochemical denitrogenation of 1,4-diaryl-2,3-diazabicyclo[2.2.1]heptane (AZ6) bearing sterically hindered substituents, a curious new absorption band at about 450 nm was observed under low-temperature matrix conditions, together with the previously well-characterized planar singlet diradical pl-(1) DR6 with λmax =≈580 nm.
Chronic stress regulates NG2(+) cell maturation and myelination in the prefrontal cortex through induction of death receptor 6.
Li et al., Nanchang, China. In Exp Neurol, Feb 2016
These alterations, are phenocopied by overexpression of death receptor 6 (DR6) in NG2(+) cells.
Death Receptor 6 and Caspase-6 Regulate Prion Peptide-Induced Axonal Degeneration in Rat Spinal Neurons.
Yang et al., Beijing, China. In J Mol Neurosci, Aug 2015
In an in vitro prion model, we observed that treatment of rat spinal neurons with the prion peptide, PrP106-126, activated death receptor 6 (DR6, also known as TNFRSF21), caspase-6, caspase-3, and induced axonal degeneration.
Analysis of the Humoral Immune Response to Human Leukocyte Antigens in Turkish Renal Transplant Candidates and Relationship Between Autoimmune Disorders.
Carin et al., İstanbul, Turkey. In Transplant Proc, Jun 2015
The specificities of anti-HLA antibodies-A23, A68, A69, B27, B49, DR6, and DR8-were the most frequent.
HIV related pulmonary arterial hypertension: epidemiology in Africa, physiopathology, and role of antiretroviral treatment.
Koulla-Shiro et al., Yaoundé, Cameroon. In Aids Res Ther, 2014
The physiopathology includes cytokines secretion increase which induces dysregulation of endothelial and vascular smooth muscle cell growth and imbalance of endogenous vasodilators and constrictors; HIV viral proteins which induces vascular oxidative stress, smooth myocyte proliferation and migration, and endothelial injury and genetic predisposition due to some major histocompatibility complex alleles, particularly HDL-DR6 and HLA-DR5.
Role of death receptors in the regulation of hepatocyte proliferation and apoptosis during rat liver regeneration.
Xu et al., Xinxiang, China. In Genet Mol Res, 2014
The results revealed that the expression levels of multiple key genes in three death receptor (DR) pathways, Fas/FasL, TNFR/TNFα, and DR6, were significantly altered in hepatocytes after PH.
MiR-210 inhibits NF-κB signaling pathway by targeting DR6 in osteoarthritis.
Zhao et al., Xi'an, China. In Sci Rep, 2014
Results of luciferase activity assay showed that miR-210 targeted 3'-UTR of death receptor 6 (DR6) to inhibit its expression.
Structural determinants of DISC function: new insights into death receptor-mediated apoptosis signalling.
Szegezdi et al., Galway, Ireland. In Pharmacol Ther, 2013
Eight members of the death receptor family have been identified in humans, which can be divided into four structurally homologous groups or clades, namely: the p75(NTR) clade (consisting of ectodysplasin A receptor, death receptor 6 (DR6) and p75 neurotrophin (NTR) receptor); the tumour necrosis factor receptor 1 clade (TNFR1 and DR3), the CD95 clade (CD95/FAS) and the TNF-related apoptosis-inducing ligand receptor (TRAILR) clade (TRAILR1 and TRAILR2).
Death receptor 6 induces apoptosis not through type I or type II pathways, but via a unique mitochondria-dependent pathway by interacting with Bax protein.
Xu et al., Knoxville, United States. In J Biol Chem, 2012
DR6-induced apoptosis occurs through a new pathway that is different from the type I and type II pathways through interacting with Bax.
S-SAD phasing study of death receptor 6 and its solution conformation revealed by SAXS.
Liu et al., Beijing, China. In Acta Crystallogr D Biol Crystallogr, 2012
SAXS measurements on the ectodomain suggested that a dimer defines the minimal physical unit of an unliganded DR6 molecule in solution.
Mapping of clinical and expression quantitative trait loci in a sex-dependent effect of host susceptibility to mouse-adapted influenza H3N2/HK/1/68.
Vidal et al., Montréal, Canada. In J Immunol, 2012
Pla2g7 and Tnfrsf21 have been identified as genetic susceptibility to influenza genes in mice.
DR6 as a diagnostic and predictive biomarker in adult sarcoma.
Buckanovich et al., Ann Arbor, United States. In Plos One, 2011
DR6 serum protein may be a tool to aid in the diagnosis of some sarcomatous tumors to improve treatment planning.
Harnessing tumor necrosis factor receptors to enhance antitumor activities of drugs.
Muntané, Córdoba, Spain. In Chem Res Toxicol, 2011
Cell death involving DR is mediated by the superfamily of tumor necrosis factor receptor (TNF-R) which includes TNF-R type I, CD95, DR3, TNF-related apoptosis-inducing ligand (TRAIL) receptor-1 (TRAIL-R1) and -2 (TRAIL-R2), DR6, ectodysplasin A (EDA) receptor (EDAR), and the nerve growth factor (NGF) receptor (NGFR).
Death receptor 6 negatively regulates oligodendrocyte survival, maturation and myelination.
Pepinsky et al., Cambridge, United States. In Nat Med, 2011
role in oligodendrocyte survival, differentiation and myelination
[Overview of potential oncomarkers for detection of early stages of ovarian cancer].
Mareková et al., Košice, Slovakia. In Klin Onkol, 2010
Death receptor 6 (DR6) and glycoprotein M6B (GPM6B), both detectable from patients serum, are among the most promising candidates for a marker of an early stage of ovarian cancer.
Tyrosine phosphorylation and CD95: a FAScinating switch.
Martin-Villalba et al., Heidelberg, Germany. In Cell Cycle, 2009
Death receptors are a subfamily of the TNF receptor superfamily, which includes the TNF receptor-I (TNFR1), TRAMP, DR3/APO-3, TRAIL-receptor 1 (TRAIL-R1/DR4), TRAIL-receptor 2 (TRAIL-R1/DR5), DR6 and CD95 (Fas/Apo-1).
APP binds DR6 to trigger axon pruning and neuron death via distinct caspases.
Tessier-Lavigne et al., San Francisco, United States. In Nature, 2009
results indicate that APP and DR6 are components of a neuronal self-destruction pathway, and suggest that an extracellular fragment of APP, acting via DR6 and caspase 6, contributes to Alzheimer's disease
Enhanced CD4+ T cell proliferation and Th2 cytokine production in DR6-deficient mice.
Yang et al., Indianapolis, United States. In Immunity, 2001
We have found that DR6, a member of the TNF receptor family, is highly expressed in resting T cells and downregulated in activated T cells.
Influence of non-inherited maternal HLA antigens on occurrence of rheumatoid arthritis.
van Rood et al., Leiden, Netherlands. In Lancet, 1993
Unexpectedly, we also found an increased frequency of non-inherited maternal HLA-DR6 and a decreased frequency of non-inherited maternal HLA-DR3 in the mothers of DR4-positive patients.
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