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Tumor necrosis factor receptor superfamily, member 10a

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: DRB1, PrP, CAN, DR3, HAD
Papers using DR4 antibodies
Rituximab-associated infections
Haque Azizul et al., In Clinical and Developmental Immunology, 2009
... residues 188–203 and 145–159, respectively, and were generated by immunization of DR4-transgenic mice as described [ ...
Visualizing antigen specific CD4+ T cells using MHC class II tetramers
Nepom G T et al., In Genes and Immunity, 2008
... T cell epitopes of insulin defined in HLA-DR4 transgenic mice are derived from ...
A phase I study of intravenous LBH589, a novel cinnamic hydroxamic acid analogue histone deacetylase inhibitor, in patients with refractory hematologic malignancies.
Jin Dong-Yan, In PLoS ONE, 2005
... Mouse monoclonal anti-DR4 antibody (B-N28) was purchased from Diaclone (Stamford, CT) ...
Functional avidity directs T-cell fate in autoreactive CD4+ T cells
Myers Linda K et al., In Arthritis Research & Therapy, 2004
... The production of the chimeric genes and the B10.M-DR4 transgenic mouse has been described ...
Osteoclasts enhance myeloma cell growth and survival via cell-cell contact: a vicious cycle between bone destruction and myeloma expansion.
Zhang Luwen, In PLoS ONE, 2003
... DcR2, Fas ligand, Fas, CD40 and CD27 from R&D Systems (Minneapolis, MN); rabbit polyclonal anti-human DR4 (ectodomain-specific) antibody from Santa Cruz Biotechnology (Santa Cruz, CA); fluorescein ...
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Papers on DR4
The probiotic Propionibacterium freudenreichii as a new adjuvant for TRAIL-based therapy in colorectal cancer.
Jan et al., Rennes, France. In Oncotarget, Feb 2016
The revealed synergistic pro-apoptotic effect, depending on both death receptors (TRAIL-R1/DR4, TRAIL-R2/DR5) and caspases (caspase-8, -9 and -3) activation, was lethal on cancer cells but not on normal human intestinal epithelial cells (HIEC), and was inhibited by Bcl-2 expression.
S-nitrosylation in TNF superfamily signaling pathway: Implication in cancer.
Bettaieb et al., Dijon, France. In Redox Biol, Dec 2015
In the tumor microenvironment, stimulation of Fas, Death receptor 4 (DR4) and tumor necrosis factor receptor 1 (TNFR1) can initiate multiple signaling pathways driving either tumor promotion or elimination.
Associations of human leukocyte antigens with autoimmune diseases: challenges in identifying the mechanism.
Tokunaga et al., Chiba, Japan. In J Hum Genet, Nov 2015
The mechanism of genetic associations between human leukocyte antigen (HLA) and susceptibility to autoimmune disorders has remained elusive for most of the diseases, including rheumatoid arthritis (RA) and type 1 diabetes (T1D), for which both the genetic associations and pathogenic mechanisms have been extensively analyzed.
Immunogenetics of type 1 diabetes: A comprehensive review.
Noble, Oakland, United States. In J Autoimmun, Nov 2015
Not all DR3 and DR4 haplotypes are high T1D risk; some versions, rare in Europeans but high frequency in other populations, are even T1D protective.
Prediction and prevention of type 1 diabetes: update on success of prediction and struggles at prevention.
Pietropaolo et al., Aurora, United States. In Pediatr Diabetes, Nov 2015
The well-known association of T1DM with certain human histocompatibility leukocyte antigen (HLA) alleles of the major histocompatibility complex (MHC) was a major step toward understanding the role of inheritance in T1DM.
Prevention of Tumor Formation by Latent Gammaherpesvirus Infection.
Adler et al., München, Germany. In Plos One, 2014
To further challenge this concept, specifically regarding increased resistance to tumors, we infected chimeric HLA-DR4-H2-E (DR4) mice, a mouse strain which spontaneously develops hematological tumors, with the rodent herpesvirus murine gammaherpesvirus 68 (MHV-68).
Combination Treatment with Sublethal Ionizing Radiation and the Proteasome Inhibitor, Bortezomib, Enhances Death-Receptor Mediated Apoptosis and Anti-Tumor Immune Attack.
Garnett-Benson et al., Tokat, Turkey. In Int J Mol Sci, 2014
We examined cells for changes in the expression of several death receptors (DR4, DR5 and Fas) commonly used by T cells for killing of target cells.
Molecular Genetic Advances in Uveitis.
Yang et al., Chongqing, China. In Prog Mol Biol Transl Sci, 2014
Genes encoding for human leukocyte antigens (HLAs) have been shown to be associated with certain uveitis entities, including BD (HLA-B51), VKH syndrome (HLA-DR4, DRB1/DQA1), AAU (HLA-B27), and BCR (HLA-A29).
CD4+ T Cells Targeting Dominant and Cryptic Epitopes from Bacillus anthracis Lethal Factor.
Altmann et al., Baltimore, United States. In Front Microbiol, 2014
Immunodominant epitopes LF457-476 and LF467-487 were found to induce a T cell response to the peptide, as well as to the whole native LF protein in DR1 and DR15, but not in DR4 transgenics.
Genetic variants in the tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) do not contribute but Death Receptor (DR4) genes may contribute to susceptibility to head and neck cancer in Pakistani population.
Ismail et al., Islamabad, Pakistan. In Cell Mol Biol (noisy-le-grand), 2014
Recent breakthroughs have shown that overexpression of anti-apoptotic proteins, inactivation of pro-apoptotic proteins, transcriptional downregulation of TRAIL, DR4/DR5, degradation of DR/DR5 are some of the mechanisms which dramatically abrogate TRAIL induced apoptosis in cancer cells.
Risk of pediatric celiac disease according to HLA haplotype and country.
TEDDY Study Group et al., Sierra Leone. In N Engl J Med, 2014
BACKGROUND: The presence of HLA haplotype DR3-DQ2 or DR4-DQ8 is associated with an increased risk of celiac disease.
Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children.
Eisenbarth et al., München, Germany. In Jama, 2013
for children with the human leukocyte antigen (HLA) genotype DR3/DR4-DQ8 (HR, 1.35 [95% CI, 1.09-1.68;
A magnetic switch for the control of cell death signalling in in vitro and in vivo systems.
Cheon et al., Seoul, South Korea. In Nat Mater, 2012
conjugated with a targeting antibody for death receptor 4 (DR4) of DLD-1 colon cancer cells.
Down-regulation of Cbl-b by bufalin results in up-regulation of DR4/DR5 and sensitization of TRAIL-induced apoptosis in breast cancer cells.
Liu et al., Shenyang, China. In J Cancer Res Clin Oncol, 2012
Data show that bufalin-induced down-regulation of Cbl-b contributed to the up-regulation of TRAIL Receptors DR4 and DR5.
A functional, new short isoform of death receptor 4 in Ewing's sarcoma cell lines may be involved in TRAIL sensitivity/resistance mechanisms.
Rédini et al., Nantes, France. In Mol Cancer Res, 2012
DR4, both as the complete form or as its new short isoform, is involved in TRAIL sensitivity in Ewing's sarcoma.
TRAIL receptor I (DR4) polymorphisms C626G and A683C are associated with an increased risk for hepatocellular carcinoma (HCC) in HCV-infected patients.
Nischalke et al., Bonn, Germany. In Bmc Cancer, 2011
we found that the TRAIL receptor I wild type with threonine at amino acid position 209 (626C) and alanine at position 228 (638A) is associated with an increased risk of Hepatocellular carcinoma in patients with chronic hepatitis C.
No gender differences in the frequencies of HLA-DRB3/B4/B5 heterozygotes in newborns and adults in Koreans.
Park et al., Seoul, South Korea. In Genes Genet Syst, 2011
There are no significant differences in the HLA-DRB3/B4/B5 homozygosity and heterozygosity rates between Korean males and females in both newborns and adults.
APC/C-mediated degradation of dsRNA-binding protein 4 (DRB4) involved in RNA silencing.
Genschik et al., Strasbourg, France. In Plos One, 2011
APC10 interacts with DRB4 through the second dsRNA binding motif (dsRBD2) of DRB4, which is also required for its homodimerization and binding to its Dicer partner DCL4.
Phase I dose-escalation study of recombinant human Apo2L/TRAIL, a dual proapoptotic receptor agonist, in patients with advanced cancer.
Mendelson et al., Houston, United States. In J Clin Oncol, 2010
PURPOSE: Apoptosis ligand 2/tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL)-a member of the tumor necrosis factor cytokine family-induces apoptosis by activating the extrinsic pathway through the proapoptotic death receptors DR4 and DR5.
Mapatumumab, an antibody targeting TRAIL-R1, in combination with paclitaxel and carboplatin in patients with advanced solid malignancies: results of a phase I and pharmacokinetic study.
Eckhardt et al., Aurora, United States. In J Clin Oncol, 2009
PURPOSE: A phase I study assessed the safety, tolerability, pharmacokinetics, and preliminary antitumor effect of mapatumumab, a fully-human agonist monoclonal antibody to the tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1, DR4), in combination with paclitaxel and carboplatin.
More papers using DR4 antibodies
Extra-articular cartilage affected in collagen-induced, but not pristane-induced, arthritis models
Holmdahl Rikard et al., In Arthritis Research & Therapy, 2001
... The human DR4 transgenic and the backcrossed B-cell ...
Determining significant fold differences in gene expression analysis
Koup Richard A, In PLoS Pathogens, 2000
... TRAIL-R1/DR4 antibody and soluble human recombinant TRAIL were obtained from Axxora LLC ...
Generation of tissue-specific and promiscuous HLA ligand databases using DNA microarrays and virtual HLA class II matrices.
Bell David A et al., In Arthritis Research & Therapy, 1998
... HLA-DR4-IE transgenic, murine MHC class II ...
An intralysosomal hsp70 is required for a selective pathway of lysosomal protein degradation
Blum Janice S. et al., In The Journal of Experimental Medicine, 1996
... presented by HLA-DR4 (provided by Linda Wicker, Merck Research Laboratories, Rahway, NJ) ...
Absence of γ-Interferon–inducible Lysosomal Thiol Reductase in Melanomas Disrupts T Cell Recognition of Select Immunodominant Epitopes
Blum Janice S. et al., In The Journal of Experimental Medicine, 1994
... for Ig κ peptides presented in the context of HLA-DR4, were generated by immunization of DR4 (DRB1*0401)-transgenic mice with human IgG ...
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