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Tumor necrosis factor receptor superfamily, member 25

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, AGE, HAD, DR4, V1a
Papers using DR3 antibodies
Aberrant expression and function of death receptor-3 and death decoy receptor-3 in human cancer
Huot Jacques et al., In BMC Cancer, 2010
... Live HT29 cells were transfected by electroporation with human DR3 siRNA purchased from Qiagen.
Oncolytic adenoviral mutants with E1B19K gene deletions enhance gemcitabine-induced apoptosis in pancreatic carcinoma cells and anti-tumor efficacy in vivo
Mahieux Renaud, In PLoS ONE, 2008
... cell lines PC-3 (ECACC, UK), DU145 and 22Rv1 (ATCC, USA), the murine prostate cell lines TRAMP-C1 (mouse transgenic Probasin-TAg prostate cancer; ATCC) ...
Nitric oxide causes macrophage migration via the HIF-1-stimulated small GTPases Cdc42 and Rac1
Hong Ji-Hong et al., In Frontiers in Oncology, 2008
... The TRAMP-C1 prostate cancer cell line was derived from transgenic mice with adenocarcinoma of ...
Valproic acid, a histone deacetylase inhibitor, is an antagonist for oncolytic adenoviral gene therapy.
Cheriyath Venugopalan, In PLoS ONE, 2005
... The murine prostate adenocarcinoma TRAMP-C2 was cultured in DMEM supplemented with 5% FBS, 5% NuSerum (Becton Dickinson, Franklin Lakes, NJ), 1 nM ...
D-galactosamine lethality model: scope and limitations.
Fritz Jörg, In PLoS ONE, 2003
... AE°.HLA-DR3 transgenic mice expressing the functional ...
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Papers on DR3
Anti-inflammatory therapies in TRAMP mice: delay in prostate cancer progression.
Cagnon et al., Campinas, Brazil. In Endocr Relat Cancer, Feb 2016
UNASSIGNED: The aim of this study was to evaluate the immediate and late responses of prostatic cancer in structural and molecular biology in the transgenic adenocarcinoma of the mouse prostate mice (TRAMP), after Goniothalamin and Celecoxib treatments.
Rrp6: Integrated roles in nuclear RNA metabolism and transcription termination.
Mosley et al., Indianapolis, United States. In Wiley Interdiscip Rev Rna, Jan 2016
Generally, the cofactor TRAMP (Trf4/5-Air2/1-Mtr4 polyadenylation) complex helps unwind unstable RNAs, RNAs requiring processing such as rRNAs, tRNAs, or snRNAs or improperly processed RNAs and direct it toward the exosome.
An immune-inflammation gene expression signature in prostate tumors of smokers.
Ambs et al., Georgetown, Guyana. In Cancer Res, Jan 2016
In an alternate approach to characterize smoking-induced oncogenic alterations, we also explored the effects of nicotine in human prostate cancer cells and prostate cancer-prone TRAMP mice.
Dendritic cells pulsed with tumor cells killed by high hydrostatic pressure induce strong immune responses and display therapeutic effects both in murine TC-1 and TRAMP-C2 tumors when combined with docetaxel chemotherapy.
Reiniš et al., Praha, Czech Republic. In Int J Oncol, Jan 2016
HHP was able to induce immunogenic cell death of both TC-1 and TRAMP-C2 tumor cells, representing murine models for human papilloma virus-associated tumors and prostate cancer, respectively.
Ad5/35E1aPSESE4: A novel approach to marking circulating prostate tumor cells with a replication competent adenovirus controlled by PSA/PSMA transcription regulatory elements.
Lee et al., South Korea. In Cancer Lett, Jan 2016
Furthermore, for the in vivo model, blood drawn from TRAMP was tested for CTCs with Ad5/35E1aPSESE4 infection and was positive for CTCs at week 16.
Exploring the Role of Killer Cell Immunoglobulin-Like Receptors and Their HLA Class I Ligands in Autoimmune Hepatitis.
Carcassi et al., Cagliari, Italy. In Plos One, Dec 2015
In our cohort, type 1 autoimmune hepatitis was strongly associated with the HLA-B18, Cw5, DR3 haplotype.
Immunogenetics of type 1 diabetes: A comprehensive review.
Noble, Oakland, United States. In J Autoimmun, Nov 2015
Not all DR3 and DR4 haplotypes are high T1D risk; some versions, rare in Europeans but high frequency in other populations, are even T1D protective.
Immunogenetics of autoimmune thyroid diseases: A comprehensive review.
Tomer et al., New York City, United States. In J Autoimmun, Nov 2015
AITD susceptibility genes can be categorized as either thyroid specific (Tg, TSHR) or immune-modulating (FOXP3, CD25, CD40, CTLA-4, HLA), with HLA-DR3 carrying the highest risk.
Novel analogs of 1,25-dihydroxyvitamin D2 combined with a plant polyphenol as highly efficient inducers of differentiation in human acute myeloid leukemia cells.
Danilenko et al., Beersheba, Israel. In J Steroid Biochem Mol Biol, Oct 2015
However, surprisingly, carnosic acid was able to significantly enhance only 1,25(OH)2D3-induced transactivation of the direct repeat 3 (DR3)-type vitamin D response element (VDRE), whereas no such cooperation was seen with 1,25(OH)2D2 analogs.
In vitro Diagnosis of Immediate Drug Hypersensitivity: Should We Go with the Flow.
Ebo et al., Antwerp, Belgium. In Int Arch Allergy Immunol, 2014
Drug provocation tests (DPT) are considered the 'gold standard' diagnostic but are not always possible, for ethical and practical reasons.
Risk of pediatric celiac disease according to HLA haplotype and country.
TEDDY Study Group et al., Sierra Leone. In N Engl J Med, 2014
BACKGROUND: The presence of HLA haplotype DR3-DQ2 or DR4-DQ8 is associated with an increased risk of celiac disease.
Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children.
Eisenbarth et al., München, Germany. In Jama, 2013
for children with the human leukocyte antigen (HLA) genotype DR3/DR4-DQ8 (HR, 1.35 [95% CI, 1.09-1.68;
The death receptor 3/TL1A pathway is essential for efficient development of antiviral CD4⁺ and CD8⁺ T-cell immunity.
Wang et al., Cardiff, United Kingdom. In Faseb J, 2012
This is the first description of DR3 regulating virus-specific T-cell function in vivo and uncovers a critical role for DR3 in mediating antiviral immunity.
Proteomics reveals drastic increase of extracellular matrix proteins collagen and dermatopontin in the aged mdx diaphragm model of Duchenne muscular dystrophy.
Ohlendieck et al., Ireland. In Int J Mol Med, 2012
Aging in the mdx diaphragm seems to be associated with a drastic increase in extracellular matrix proteins incliding dermatopontin.
Involvement of TL1A and DR3 in induction of ischaemia and inflammation in urinary bladder dysfunction in the elderly.
Yang et al., Beijing, China. In Mol Med Report, 2012
Protein expression of tumour necrosis factor (TNF)-like ligand 1A (TL1A) and death-domain receptor (DR)3 is upregulated in the aged bladder tissues.
DR3 signaling protects against cisplatin nephrotoxicity mediated by tumor necrosis factor.
Bradley et al., Cambridge, United Kingdom. In Am J Pathol, 2012
DR3 signaling protects against cisplatin nephrotoxicity mediated by tumor necrosis factor.
Death receptor 3 is essential for generating optimal protective CD4⁺ T-cell immunity against Salmonella.
Al-Shamkhani et al., Southampton, United Kingdom. In Eur J Immunol, 2012
DR3 facilitates clearance of Salmonella typhimurium in vivo.
The RNA helicase Mtr4p modulates polyadenylation in the TRAMP complex.
Jankowsky et al., Cleveland, United States. In Cell, 2011
Many steps in nuclear RNA processing, surveillance, and degradation require TRAMP, a complex containing the poly(A) polymerase Trf4p, the Zn-knuckle protein Air2p, and the RNA helicase Mtr4p.
Clr4/Suv39 and RNA quality control factors cooperate to trigger RNAi and suppress antisense RNA.
Grewal et al., Bethesda, United States. In Science, 2011
Mlo3 also interacts with the RNA surveillance factor TRAMP, which suppresses antisense RNAs targeted by Clr4 and RNAi.
Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors.
Ronai et al., Los Angeles, United States. In Cancer Cell, 2010
Formation of NE prostate tumors in the TRAMP mouse model was suppressed in mice lacking the ubiquitin ligase Siah2, which regulates HIF-1alpha availability.
More papers using DR3 antibodies
Immunology of spontaneous mammary carcinomas in mice. V. Acquired tumor resistance and enhancement in strain A mice infected with mammary tumor virus.
Lebedeva Irina V., In PLoS ONE, 1965
... Female C57Bl/6 TRAMP mice heterozygous for the Probasin SV-40 Tag transgene were bred to non-transgenic C57Bl/6 males (Taconic M&B, ...
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