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proteins. Page last changed on 19 Dec 2016.
Tumor necrosis factor receptor superfamily, member 25
DR3, DPT, TRAMP
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq, Jul 2008] (from
Cagnon et al., Campinas, Brazil. In Endocr Relat Cancer, Feb 2016
UNASSIGNED: The aim of this study was to evaluate the immediate and late responses of prostatic cancer in structural and molecular biology in the transgenic adenocarcinoma of the mouse prostate mice (TRAMP), after Goniothalamin and Celecoxib treatments.
Mosley et al., Indianapolis, United States. In Wiley Interdiscip Rev Rna, Jan 2016
Generally, the cofactor TRAMP (Trf4/5-Air2/1-Mtr4 polyadenylation) complex helps unwind unstable RNAs, RNAs requiring processing such as rRNAs, tRNAs, or snRNAs or improperly processed RNAs and direct it toward the exosome.
Danilenko et al., Beersheba, Israel. In J Steroid Biochem Mol Biol, Oct 2015
However, surprisingly, carnosic acid was able to significantly enhance only 1,25(OH)2D3-induced transactivation of the direct repeat 3 (DR3)-type vitamin D response element (VDRE), whereas no such cooperation was seen with 1,25(OH)2D2 analogs.