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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

RAM1 Ram1p

DPR1, RAM1, Frodo, Dact1, Dapper, Dapper1
The protein encoded by this gene belongs to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. It interacts with, and positively regulates dishevelled-mediated signaling pathways during development. Depletion of this mRNA from xenopus embryos resulted in loss of notochord and head structures, and mice lacking this gene died shortly after birth from severe posterior malformations. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012] (from NCBI)
Top mentioned proteins: PKI, CAN, ACID, HAD, V1a
Papers on DPR1
Hyphal Branching during Arbuscule Development Requires Reduced Arbuscular Mycorrhiza1.
New
Harrison et al., Ithaca, United States. In Plant Physiol, Dec 2015
Here, we provide a detailed characterization of an insertion allele of Medicago truncatula Reduced Arbuscular Mycorrhiza1 (RAM1), ram1-3, which reveals that RAM1 is not necessary to enable hyphopodium formation or hyphal entry into the root but is essential to support arbuscule branching.
Development of a Real-Time PCR-Based Method for Analyzing Semen-Specific Unmethylated DNA Regions and Methylation Status in Aged Body Fluid Stains.
New
Sakurada et al., Kashiwa, Japan. In J Forensic Sci, Sep 2015
In this study, we report the development of a real-time polymerase chain reaction-based method for identifying semen that can simply and rapidly analyze the semen-specific unmethylated region of the DACT1 gene.
DAPPER: a data-mining resource for protein-protein interactions.
Glover et al., Cambridge, United Kingdom. In Biodata Min, 2014
Here we describe a database coupled with a mining tool for protein-protein interactions (DAPPER), developed as a rich resource for studying multi-protein complexes in Drosophila melanogaster.
Pre-announcement of symbiotic guests: transcriptional reprogramming by mycorrhizal lipochitooligosaccharides shows a strict co-dependency on the GRAS transcription factors NSP1 and RAM1.
Küster et al., Hannover, Germany. In Bmc Genomics, 2014
Using complex gene expression fingerprints as molecular phenotypes, this study primarily intended to shed light on the importance of the GRAS TFs NSP1 and RAM1 for LCO-activated gene expression during pre-symbiotic signaling.
SIRT1 inhibits adipogenesis and promotes myogenic differentiation in C3H10T1/2 pluripotent cells by regulating Wnt signaling.
Jiang et al., Wuhan, China. In Cell Biosci, 2014
SIRT1 suppressed the expression of Wnt signaling antagonists sFRP2 and DACT1.
A consideration of the evidence that genetic defects in planar cell polarity contribute to the etiology of human neural tube defects.
Review
Harris et al., Vancouver, Canada. In Birth Defects Res A Clin Mol Teratol, 2012
Rare putative mutations in the PCP genes VANGL2, SCRIB, DACT1, and CELSR1 cumulatively contributed to over 20% of cases with craniorachischisis, a rare defect; no contributing variants were found for PRICKLE1 or PTK7.
Oncogenic function of DACT1 in colon cancer through the regulation of β-catenin.
GeneRIF
Fu et al., Beijing, China. In Plos One, 2011
DACT1 stabilizes beta-catenin via DACT1-induced effects on GSK-3beta and directly interacts with beta-catenin proteins.
Cytoplasmic HDPR1 is involved in regional lymph node metastasis and tumor development via beta-catenin accumulation in esophageal squamous cell carcinoma.
GeneRIF
Xu et al., Shantou, China. In J Histochem Cytochem, 2011
Cytoplasmic HDPR1 protein expression was associated with tumor malignant progression via beta-catenin accumulation.
HLA class II DPB1 and DRB1 polymorphisms associated with genetic susceptibility to beryllium toxicity.
Review
Monos et al., East Lansing, United States. In Occup Environ Med, 2011
Our objective was to extend current knowledge of the genetics of beryllium disease by examining all HLA-DPB1 and HLA-DPR1 gene polymorphisms and the interactions between them.
Protein kinase A-mediated 14-3-3 association impedes human Dapper1 to promote dishevelled degradation.
GeneRIF
Chen et al., Beijing, China. In J Biol Chem, 2011
14-3-3beta interacts with human Dapper1, attenuating the ability of hDpr1 to promote Dishevelled (Dvl) degradation, thus enhancing Wnt signaling
[Mechanism of As(2)O(3) on hdpr1 gene demethylation in Jurkat cell line].
GeneRIF
Zhu et al., Fuzhou, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2010
As(2)O(3) induces demethylation of hdpr1 gene from abnormal hypermethylation status and activates its reexpression, thus suppressing the proliferation of Jurkat cells.
All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases.
GeneRIF
Cheyette et al., San Francisco, United States. In Bmc Biochem, 2010
conserved role for Dact1 protein in kinase-regulated biochemistry involving Vangl and Dvl.
Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak.
Impact
GeneRIF
Cheyette et al., San Francisco, United States. In Nat Genet, 2009
Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak.
DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications.
Impact
Yu et al., Singapore, Singapore. In Cancer Cell, 2008
Here we identify DACT3, a member of the DACT (Dpr/Frodo) gene family, as a negative regulator of Wnt/beta-catenin signaling that is transcriptionally repressed in colorectal cancer.
Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis.
Review
Katoh, Tokyo, Japan. In Stem Cell Rev, 2007
In 2003, we identified and characterized PRICKLE1, PRICKLE2, DACT1/DAPPER1, DACT2/DAPPER2, DAAM2, and BCL9L.
Frodo proteins: modulators of Wnt signaling in vertebrate development.
Review
Sokol et al., New York City, United States. In Differentiation, 2005
The Frodo/dapper (Frd) proteins are recently discovered signaling adaptors, which functionally and physically interact with Wnt and Nodal signaling pathways during vertebrate development.
Frodo interacts with Dishevelled to transduce Wnt signals.
Impact
Sokol et al., Boston, United States. In Nat Cell Biol, 2002
Frodo, a novel conserved Dsh-binding protein, synergized with Xenopus Dsh (XDsh) in secondary axis induction in Xenopus laevis embryos.
Protein prenylation in eukaryotic microorganisms: genetics, biology and biochemistry.
Review
Gibbs et al., Point Pedro, Sri Lanka. In Mol Microbiol, 1994
The initial genetic analysis of prenyl protein transferases was in S. cerevisiae with the isolation and subsequent characterization of mutations in the RAM1, RAM2, CDC43 and BET2 genes, each of which encodes a prenyl protein transferase subunit.
cDNA cloning and expression of the peptide-binding beta subunit of rat p21ras farnesyltransferase, the counterpart of yeast DPR1/RAM1.
Impact
Brown et al., Dallas, United States. In Cell, 1991
The rat beta subunit shows 37% sequence identity with the protein encoded by the yeast DPR1/RAM1 gene, indicating that DPR1/RAM1 is the yeast counterpart of the peptide-binding subunit of the mammalian farnesyltransferase.
Enzymatic coupling of cholesterol intermediates to a mating pheromone precursor and to the ras protein.
Impact
Rine et al., Berkeley, United States. In Science, 1990
In the yeast Saccharomyces cerevisiae, the product of the DPR1-RAM1 gene participates in this type of processing.
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