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Developmental pluripotency associated 5A

DPPA5, Esg-1, PH34, developmental pluripotency associated 5
This gene encodes a protein that may function in the control of cell pluripotency and early embryogenesis. Expression of this gene is a specific marker for pluripotent stem cells. Pseudogenes of this gene are located on the short arm of chromosome 10 and the long arm of chromosomes 14 and 19. [provided by RefSeq, Dec 2010] (from NCBI)
Top mentioned proteins: Nanog, Sox2, Rex-1, CAN, KLF4
Papers on DPPA5
DPPA5 Supports Pluripotency and Reprogramming by Regulating NANOG Turnover.
New
Krebsbach et al., Ann Arbor, United States. In Stem Cells, Jan 2016
Here, we demonstrate that the PSC marker Developmental Pluripotency Associated 5 (DPPA5) plays an important role in human PSC (hPSC) self-renewal and cell reprogramming in feeder-free conditions.
Stem Cell-Derived Bioactive Materials Accelerate Development of Porcine In Vitro-Fertilized Embryos.
New
Park et al., Cheju, South Korea. In Cell Reprogram, Jun 2015
The relative expression of reprogramming-related transcription factor (POU5F1, SOX2, DPPA5, and CDH1), antioxidant (PRDX5), and apoptosis (BCL2L1 and BIRC5) genes also increased in two types of BMs compared to the control.
Sox2 is the faithful marker for pluripotency in pig: evidence from embryonic studies.
New
Liu et al., Harbin, China. In Dev Dyn, Apr 2015
RESULTS: To explore molecular basis of porcine TE/ICM specification and pluripotent regulatory networks, we examined expression pattern of pluripotency factors, including SOX2, REX1, SALL4, ESG1, NANOG, TBX3, LIN28, KLF2, and KLF5, in porcine blastocysts.
Brain-specific epigenetic markers of schizophrenia.
Voisey et al., Brisbane, Australia. In Transl Psychiatry, 2014
The regions were near CERS3, DPPA5, PRDM9, DDX43, REC8, LY6G5C and a region on chromosome 10.
Dppa5 improves hematopoietic stem cell activity by reducing endoplasmic reticulum stress.
Karlsson et al., Lund, Sweden. In Cell Rep, 2014
Developmental pluripotency-associated 5 (Dppa5) is an RNA binding protein highly expressed in undifferentiated pluripotent stem cells.
Low pH reprograms somatic murine cells into pluripotent stem cells: a novel technique with therapeutic implications.
Review
Brownell et al., Bethesda, United States. In Cancer Biol Ther, 2014
STAP cells display several features of pluripotency, namely the expression of pluripotency-related genes (Oct4, Nanog, Sox2, Ecat1, Esg1, and Dax1), the ability to form teratomas in vivo, and the ability to produce viable, fertile mice in blastocyst complementation assays.
Establishment of a primed pluripotent epiblast stem cell in FGF4-based conditions.
Schöler et al., Münster, Germany. In Sci Rep, 2013
EpiSCs also expressed higher levels of epiblast markers, such as Cer1, Eomes, Fgf5, Sox17, and T, and further showed complete DNA methylation of Stella and Dppa5 promoters.
Efficient reprogramming of naïve-like induced pluripotent stem cells from porcine adipose-derived stem cells with a feeder-independent and serum-free system.
Zhang et al., Hefei, China. In Plos One, 2013
Full reprogramming of naïve-like piPSCs was evaluated by the significant up-regulation of Lin28, Esrrb, Utf1 and Dppa5, differentiating into cell types of all three germ layers in vitro and in vivo.
Growth requirements and chromosomal instability of induced pluripotent stem cells generated from adult canine fibroblasts.
Piedrahita et al., Raleigh, United States. In Stem Cells Dev, 2013
Cells cultured in both FGF2 and LIF expressed pluripotency markers [POU5F1 (OCT4), SOX2, NANOG, and LIN28] and embryonic stem cell (ESC)-specific genes (PODXL, DPPA5, FGF5, REX1, and LAMP1) and showed strong levels of alkaline phosphatase expression.
Derivation and characterization of sleeping beauty transposon-mediated porcine induced pluripotent stem cells.
Niemann et al., Germany. In Stem Cells Dev, 2013
The transposon-reprogrammed induced pluripotent stem (iPS) cells showed long-term proliferation in vitro over >40 passages, expressed transcription factors typical of embryonic stem cells, including OCT4, NANOG, SOX2, REX1, ESRRB, DPPA5, and UTF1 and surface markers of pluripotency, including SSEA-1 and TRA-1-60.
Recombinant rabbit leukemia inhibitory factor and rabbit embryonic fibroblasts support the derivation and maintenance of rabbit embryonic stem cells.
Xu et al., College Park, United States. In Cell Reprogram, 2012
Rabbit ESCs derived and maintained on both conditions displayed typical ESC characteristics, including ESC pluripotency marker expression (AP, Oct4, Sox2, Nanog, and SSEA4) and gene expression (Oct4, Sox2, Nanog, c-Myc, Klf4, and Dppa5), and the capacity to differentiate into three primary germ layers in vitro.
A model of cancer stem cells derived from mouse induced pluripotent stem cells.
Seno et al., Okayama, Japan. In Plos One, 2011
In addition, these iPS-derived CSCs had a capacity of self-renewal and expressed the marker genes, Nanog, Rex1, Eras, Esg1 and Cripto, associated with stem cell properties and an undifferentiated state.
Data mining in networks of differentially expressed genes during sow pregnancy.
Wang et al., Beijing, China. In Int J Biol Sci, 2011
For instance, DPPA5 g.363 T>C was found to associate with litter born weight at later parities in Beijing Black pigs significantly (p < 0.05).
Co-culture of mesenchymal-like stromal cells derived from human foreskin permits long term propagation and differentiation of human embryonic stem cells.
Bhonde et al., Kuala Lumpur, Malaysia. In J Cell Biochem, 2011
hESC lines co-cultured with HF-MSC feeders showed expression of expected pluripotent transcription factors Oct-4, Nanog, Sox-2, GDF-3, Rex-1, STELLAR, ABCG2, Dppa5, hTERT; surface markers SSEA-4, TRA-1-81 and maintained their cytogenetic stability during long term passaging.
Gene birth, death, and divergence: the different scenarios of reproduction-related gene evolution.
Review
Monget et al., Tours, France. In Biol Reprod, 2009
We show that phylogenetic gene birth is confirmed by gene location in genomes, which definitively localized the "place of birth" of new genes (such as Obox and KHDC1/DPPA5/ECAT1/OOEP gene families).
Esg1, expressed exclusively in preimplantation embryos, germline, and embryonic stem cells, is a putative RNA-binding protein with broad RNA targets.
GeneRIF
Ko et al., Baltimore, United States. In Dev Growth Differ, 2006
ESG1 is an RNA-binding protein which associates with specific target transcripts such as Cdc25a, Cdc42, Ezh2, Nfyc and Nr5a2.
Identification and targeted disruption of the mouse gene encoding ESG1 (PH34/ECAT2/DPPA5).
GeneRIF
Yamanaka et al., Kyoto, Japan. In Bmc Dev Biol, 2005
Despite its specific expression in pluripotent cells and germ cells, ESG1 is dispensable for self-renewal of ES cells and establishment of germ cells.
Identification of developmental pluripotency associated 5 expression in human pluripotent stem cells.
GeneRIF
Kim et al., Seoul, South Korea. In Stem Cells, 2005
Dppa5 is specifically and differentially expressed in human cells that have pluripotency and can be used as a marker of pluripotent stem cells.
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