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Dipeptidyl-peptidase 10

DPP10, DPL2, dipeptidyl peptidase 10, DPPY
This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Kv1.4, TSG101, PHF11, ADAM33, ACID
Papers on DPP10
Coexpression of auxiliary subunits KChIP and DPPL in potassium channel Kv4-positive nociceptors and pain-modulating spinal interneurons.
New
Tsaur et al., Taipei, Taiwan. In J Comp Neurol, Apr 2016
In this study we mapped the protein distribution of KChIP1, KChIP2, KChIP3, DPP6, and DPP10 in adult rat dorsal root ganglion (DRG) and spinal cord by immunohistochemistry.
Unravelling the immunological roles of dipeptidyl peptidase 4 (DPP4) activity and/or structure homolog (DASH) proteins.
Review
New
von Hörsten et al., Stuttgart, Germany. In Clin Exp Immunol, Jan 2016
Apart from DPP4, DASH proteins include fibroblast activation protein alpha (FAP), dipeptidyl peptidase 8 (DPP8), dipeptidyl peptidase 9 (DPP9), dipeptidyl peptidase 4-like protein 1 (DPL1, DPP6, DPPX L, DPPX S), dipeptidyl peptidase 4-like protein 2 (DPL2, DPP10) from the DPP4-gene family S9b and structurally unrelated enzyme dipeptiyl peptidase 2 (DPP2), displaying DPP4-like activity.
A genome-wide association study of suicidal behavior.
New
Mann et al., München, Germany. In Am J Med Genet B Neuropsychiatr Genet, Oct 2015
The top SNPs for the suicide attempt analysis included two from DPP10, one from CTNNA3 and one from STK32B.
Kv4.2 and accessory dipeptidyl peptidase-like protein 10 (DPP10) subunit preferentially form a 4:2 (Kv4.2:DPP10) channel complex.
New
Nakajo et al., Hayama, Japan. In J Biol Chem, Oct 2015
To examine whether the expression level of DPP changes the biophysical properties of Kv4, we expressed Kv4.2 and DPP10 in different ratios in Xenopus oocytes and analyzed the currents under two-electrode voltage clamp.
Immunohistochemical localization of DPP10 in rat brain supports the existence of a Kv4/KChIP/DPPL ternary complex in neurons.
New
Tsaur et al., Taipei, Taiwan. In J Comp Neurol, Apr 2015
The distribution of DPP10 mRNA in rodent brain has been reported but its protein localization remains unknown.
Interaction of DPP10a with Kv4.3 channel complex results in a sustained current component of human transient outward current Ito.
New
Kämmerer et al., Dresden, Germany. In Basic Res Cardiol, Mar 2015
Assuming that DPP10a influences atrial Ito, we detected DPP10 expression of three alternatively spliced mRNAs, DPP10 protein and colocalization of Kv4.3 and DPP10 proteins in human atrial myocytes.
Dipeptidyl-peptidase 10 as a genetic biomarker for the aspirin-exacerbated respiratory disease phenotype.
New
Park et al., Suwŏn, South Korea. In Ann Allergy Asthma Immunol, Mar 2015
A genetic contribution of dipeptidyl-peptidase 10 (DPP10) to asthma susceptibility and lung function decline has been reported.
Association between Variants in Atopy-Related Immunologic Candidate Genes and Pancreatic Cancer Risk.
Hudson et al., Toronto, Canada. In Plos One, 2014
RESULTS: 18 SNPs in 14 candidate genes (CSF2, DENND1B, DPP10, FLG, IL13, IL13RA2, LRP1B, NOD1, NPSR1, ORMDL3, RORA, STAT4, TLR6, TRA) were significantly associated with pancreas cancer risk.
Structure of human dipeptidyl peptidase 10 (DPPY): a modulator of neuronal Kv4 channels.
Gruber et al., Graz, Austria. In Sci Rep, 2014
Dipeptidyl peptidase 10 (DPP10) is an inactive peptidase that modulates the electrophysiological properties, cell-surface expression and subcellular localization of voltage-gated potassium channels.
Fetal lung and placental methylation is associated with in utero nicotine exposure.
DeMeo et al., Boston, United States. In Epigenetics, 2014
The most significant CpG sites in the fetal lung analysis mapped to the PKP3 (P = 2.94 × 10(-03)), ANKRD33B (P = 3.12 × 10(-03)), CNTD2 (P = 4.9 × 10(-03)) and DPP10 (P = 5.43 × 10(-03)) genes.
The genome in three dimensions: a new frontier in human brain research.
Review
Akbarian et al., Worcester, United States. In Biol Psychiatry, 2014
We introduce chromosome conformation capture protocols for brain and compare higher-order chromatin structures at the chromosome 6p22.2-22.1 schizophrenia and bipolar disorder susceptibility locus, and additional neurodevelopmental risk genes, (DPP10, MCPH1) in adult prefrontal cortex and various cell culture systems, including neurons derived from reprogrammed skin cells.
Chromatin-bound RNA and the neurobiology of psychiatric disease.
Review
Akbarian et al., New York City, United States. In Neuroscience, 2014
Examples of recently discovered chromatin-bound long non-coding RNAs important for neuronal health and function include the brain-derived neurotrophic factor antisense transcript (Bdnf-AS) which regulates expression of the corresponding sense transcript, and LOC389023 which is associated with human-specific histone methylation signatures at the chromosome 2q14.1 neurodevelopmental risk locus by regulating expression of DPP10, an auxillary subunit for voltage-gated K(+) channels.
N-glycosylation of the mammalian dipeptidyl aminopeptidase-like protein 10 (DPP10) regulates trafficking and interaction with Kv4 channels.
GeneRIF
Sblattero et al., Novara, Italy. In Int J Biochem Cell Biol, 2012
demonstrated that glycosylation was necessary for both DPP10 trafficking to the cell surface and functional interaction with Kv4 channels
Augmentation of Kv4.2-encoded currents by accessory dipeptidyl peptidase 6 and 10 subunits reflects selective cell surface Kv4.2 protein stabilization.
GeneRIF
Nerbonne et al., Saint Louis, United States. In J Biol Chem, 2012
In the presence of DPP6 or DPP10, cell surface Kv4.2 protein expression is selectively increased.
Crystallization and preliminary X-ray diffraction analysis of human dipeptidyl peptidase 10 (DPPY), a component of voltage-gated potassium channels.
GeneRIF
Gruber et al., Graz, Austria. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012
Crystals of DPP10 obtained by the sitting-drop method were orthorhombic, belonging to space group P2(1)2(1)2(1) with unit-cell parameters a = 80.91, b = 143.73, c = 176.25 A.
Impaired glycosylation blocks DPP10 cell surface expression and alters the electrophysiology of Ito channel complex.
GeneRIF
Sblattero et al., Novara, Italy. In Pflugers Arch, 2010
N-linked glycosylation of DPP10 plays an important role in modulating Kv4.3 channel/KCHIP2 complex activities.
The dipeptidyl peptidase IV family in cancer and cell biology.
Review
Gorrell et al., Sydney, Australia. In Febs J, 2010
The dipeptidyl peptidase IV (DPIV) gene family, comprising four enzyme members [DPIV (EC 3.4.14.5), fibroblast activation protein, DP8 and DP9] and two nonenzyme members [DP6 (DPL1) and DP10 (DPL2)], are interesting in this regard because of their multiple diverse functions, varying patterns of distribution/localization and subtle, but significant, differences in structure/substrate recognition.
Pathogenesis of allergic airway inflammation.
Review
Shao et al., Omaha, United States. In Curr Allergy Asthma Rep, 2010
Several genes, including ADAM33, DPP10, PHF11, GPRA, TIM-1, PDE4D, OPN3, and ORMDL3, have been implicated in the pathogenesis and susceptibility to atopy and asthma.
A multi-centre study of candidate genes for wheeze and allergy: the International Study of Asthma and Allergies in Childhood Phase 2.
GeneRIF
ISAAC Phase 2 Study Group et al., Ulm, Germany. In Clin Exp Allergy, 2009
We were unable to confirm associations of single nucleotide polymorphisms of the positional candidates DPP10 and PHF11 with wheeze. Significant associations with reported and examined eczema were only observed for DPP10.
Positional cloning of a novel gene influencing asthma from chromosome 2q14.
Impact
Cookson et al., Milton Keynes, United Kingdom. In Nat Genet, 2003
SNP association was limited to the initial exons of a solitary gene of 3.6 kb (DPP10), which extends over 1 Mb of genomic DNA.
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