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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Major histocompatibility complex, class II, DP beta 1

DPB1, HLA-DPB1
HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on DPB1
HLA-DPB1*0201 is associated with susceptibility to atopic myelitis in Japanese.
GeneRIF
Kira et al., Fukuoka, Japan. In J Neuroimmunol, 2012
The HLA-DPB1*0201 allele was significantly more frequent in AM patients than in healthy controls (54.5% vs. 31.9%, corrected P value=0.0150, odds ratio=2.564, 95% confidence interval=1.444-4.554).
A novel variant marking HLA-DP expression levels predicts recovery from hepatitis B virus infection.
GeneRIF
Carrington et al., Boston, United States. In J Virol, 2012
Variant (rs9277535; 550A/G) in the 3'UTR of the HLA-DPB1 gene is associated with chronic hepatitis B and outcomes to HBV infection in Asians.
Effect of T-cell-epitope matching at HLA-DPB1 in recipients of unrelated-donor haemopoietic-cell transplantation: a retrospective study.
Impact
GeneRIF
International Histocompatibility Working Group in Hematopoietic Cell Transplantation et al., Milano, Italy. In Lancet Oncol, 2012
Avoidance of an unrelated donor with a non-permissive T-cell-epitope mismatch at HLA-DPB1 might provide a practical clinical strategy for lowering the risks of mortality after unrelated-donor haemopoietic-cell transplantation.
Full-length HLA-DPB1 diversity in multiple alleles of individuals from Caucasian, Black, or Oriental origin.
GeneRIF
Tilanus et al., Maastricht, Netherlands. In Tissue Antigens, 2012
Two alleles with identical exon 2 polymorphism but differing outside exon 2 were identified in individuals of different ethnic groups
Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis.
Impact
GeneRIF
de Bakker et al., Boston, United States. In Nat Genet, 2012
Three amino acid positions (11, 71 and 74) in HLA-DRbeta1 and single-amino-acid polymorphisms in HLA-B (position 9) and HLA-DPbeta1 (position 9), all located in peptide-binding grooves, almost completely explain MHC association to rheumatoid arthritis risk.
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