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Major histocompatibility complex, class II, DP beta 1

HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: DRB1, HLA-A, POLYMERASE, HAD, MHC
Papers on DPB1
Beryllium-Induced Hypersensitivity: Genetic Susceptibility and Neoantigen Generation.
McKee et al., Denver, United States. In J Immunol, Feb 2016
The disease is characterized by the accumulation of Be-responsive CD4(+) T cells in the lung, and genetic susceptibility is primarily linked to HLA-DPB1 alleles possessing a glutamic acid at position 69 of the β-chain.
Allele Frequencies Net Database: Improvements for storage of individual genotypes and analysis of existing data.
Middleton et al., Belém, Brazil. In Hum Immunol, Dec 2015
The gold standard includes >500 datasets covering over 3 million individuals from >100 countries at one or more of the following loci: HLA-A, -B, -C, -DPA1, -DPB1, -DQA1, -DQB1 and -DRB1 - with all loci except DPA1 present in more than 220 datasets.
Immunogenetics of juvenile idiopathic arthritis: A comprehensive review.
Prahalad et al., Salt Lake City, United States. In J Autoimmun, Nov 2015
HLA DPB1:02:01 has also been associated with oligoarticular and RF-negative polyarticular JIA.
High HLA-DP Expression and Graft-versus-Host Disease.
Stevenson et al., Frederick, United States. In N Engl J Med, Sep 2015
The risk is higher when the recipient and donor are HLA-DPB1-mismatched, but the mechanisms leading to GVHD are unknown.
Construction of a population-specific HLA imputation reference panel and its application to Graves' disease risk in Japanese.
Kubo et al., Tokyo, Japan. In Nat Genet, Jul 2015
We applied HLA imputation to genome-wide association study (GWAS) data for Graves' disease in Japanese (n = 9,003) and found that amino acid polymorphisms of multiple class I and class II HLA genes independently contribute to disease risk (HLA-DPB1, HLA-A, HLA-B and HLA-DRB1; P < 2.3 × 10(-6)), with the strongest impact at HLA-DPB1 (P = 1.6 × 10(-42)).
An HLA-C amino-acid variant in addition to HLA-B*27 confers risk for ankylosing spondylitis in the Korean population.
Kim et al., Seoul, South Korea. In Arthritis Res Ther, 2014
METHODS: Using the Korean HLA reference panel, we inferred the classic HLA alleles and amino-acid residues of the six HLA genes (HLA-A, -B, -C, -DPB1, -DQB1, and -DRB1) and MHC single-nucleotide polymorphisms in 3820 Korean subjects, including 654 Korean cases of AS and 3166 controls, who were genotyped by using Immunochip.
Network-assisted analysis of primary Sjögren's syndrome GWAS data in Han Chinese.
Wang et al., Beijing, China. In Sci Rep, 2014
Of these pSS candidates, 14 genes had been reported to be associated with any of pSS, RA, and SLE, including STAT4, GTF2I, HLA-DPB1, HLA-DRB1, PTTG1, HLA-DQB1, MBL2, TAP2, CFLAR, NFKBIE, HLA-DRA, APOM, HLA-DQA2 and NOTCH4.
Evidence for Association of Cell Adhesion Molecules Pathway and NLGN1 Polymorphisms with Schizophrenia in Chinese Han Population.
Yue et al., Beijing, China. In Plos One, 2014
Moreover, 12 genes (HLA-A, HLA-C, HLA-DOB, HLA-DPB1, HLA-DQA2, HLA-DRB1, MPZ, CD276, NLGN1, NRCAM, CLDN1 and ICAM3) were modestly significantly associated with schizophrenia (P<0.01).
Complete donor chimerism is a prerequisite for the effect of Predicted Indirectly ReCognizable HLA Epitopes (PIRCHE) on acute graft-versus-host disease.
Spierings et al., Utrecht, Netherlands. In Chimerism, 2014
Predicted indirectly recognizable HLA epitopes (PIRCHE) computationally predict donor T-cell recognition of mismatched-HLA derived peptides following allogeneic haematopoietic stem-cell transplantation (allo-HSCT), as is evidenced by the correlation between presence of HLA-DPB1-derived PIRCHE and the occurrence of graft-vs.-host
HLA and asthma phenotypes/endotypes: a review.
Daniilidis et al., Thessaloníki, Greece. In Hum Immunol, 2014
The most common HLA haplotypes in the different asthma phenotypes are HLA-DRB1in allergic asthma, HLA-DQB1in occupational asthma and HLA-DPB1 in aspirin-sensitive asthma.
An update on the contribution of the MHC to AS susceptibility.
Reveille, Houston, United States. In Clin Rheumatol, 2014
Other HLA class I and class II alleles have been implicated in AS susceptibility, the most consistent being HLA-B*40/B60 (B*40:01) but also B14, B15, A*0201, DRB1*04:04, and certain DPA1 and DPB1 alleles.
The HLA-net GENE[RATE] pipeline for effective HLA data analysis and its application to 145 population samples from Europe and neighbouring areas.
HLA-net 2013 collaboration et al., Genève, Switzerland. In Tissue Antigens, 2014
The Gene[va] database offers direct access to the HLA-A, -B, -C, -DQA1, -DQB1, -DRB1 and -DPB1 frequencies and summary statistics of 145 population samples having successfully passed these HLA-NET 'filters', and representing three European subregions (South-East, North-East and Central-West Europe) and two neighbouring areas (North Africa, as far as Sudan, and West Asia, as far as South India).
A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12.
Ma et al., Wuhan, China. In Nat Genet, 2013
We additionally replicated an association between HLA-DPB1 and HLA-DPB2 (HLA-DPB1/2) at 6p21.32 and cervical cancer (rs4282438, Pcombined, stringently matched=4.52×10(-27),
HLA-DPB1*0201 is associated with susceptibility to atopic myelitis in Japanese.
Kira et al., Fukuoka, Japan. In J Neuroimmunol, 2012
The HLA-DPB1*0201 allele was significantly more frequent in AM patients than in healthy controls (54.5% vs. 31.9%, corrected P value=0.0150, odds ratio=2.564, 95% confidence interval=1.444-4.554).
A novel variant marking HLA-DP expression levels predicts recovery from hepatitis B virus infection.
Carrington et al., Boston, United States. In J Virol, 2012
Variant (rs9277535; 550A/G) in the 3'UTR of the HLA-DPB1 gene is associated with chronic hepatitis B and outcomes to HBV infection in Asians.
Effect of T-cell-epitope matching at HLA-DPB1 in recipients of unrelated-donor haemopoietic-cell transplantation: a retrospective study.
International Histocompatibility Working Group in Hematopoietic Cell Transplantation et al., Milano, Italy. In Lancet Oncol, 2012
Avoidance of an unrelated donor with a non-permissive T-cell-epitope mismatch at HLA-DPB1 might provide a practical clinical strategy for lowering the risks of mortality after unrelated-donor haemopoietic-cell transplantation.
Full-length HLA-DPB1 diversity in multiple alleles of individuals from Caucasian, Black, or Oriental origin.
Tilanus et al., Maastricht, Netherlands. In Tissue Antigens, 2012
Two alleles with identical exon 2 polymorphism but differing outside exon 2 were identified in individuals of different ethnic groups
Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis.
de Bakker et al., Boston, United States. In Nat Genet, 2012
Three amino acid positions (11, 71 and 74) in HLA-DRbeta1 and single-amino-acid polymorphisms in HLA-B (position 9) and HLA-DPbeta1 (position 9), all located in peptide-binding grooves, almost completely explain MHC association to rheumatoid arthritis risk.
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