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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.


doublecortin, DCX
This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010] (from NCBI)
Top mentioned proteins: CAN, AGE, HAD, nestin, V1a
Papers using doublecortin antibodies
Forebrain neurogenesis after focal Ischemic and traumatic brain injury.
Zheng Jialin Charles, In PLoS ONE, 2009
... Generation of DCX-TK Transgenic Mice ...
Advances in light microscopy for neuroscience
Peretto Paolo et al., In Frontiers in Neuroscience, 2008
... solution of 0.01 M PBS, pH 7.4, containing 1% Triton X-100, normal horse serum and either anti-DCX antibody 1:500 (goat polyclonal sc-8066; Santa Cruz Biotechnology, Santa Cruz, CA, USA) ...
Regulation of neural progenitor cell state by ephrin-B
Lu Qiang et al., In The Journal of Cell Biology, 2005
... (1:100; Developmental Studies Hybridoma Bank), RC2 (1:100; Developmental Studies Hybridoma Bank), anti–βIII tubulin (1:400; Sigma-Aldrich), anti-DCX (1:50 Santa Cruz Biotechnology, Inc.), anti-BrdU (1:500; Sigma-Aldrich), ...
Is it all DNA repair? Methodological considerations for detecting neurogenesis in the adult brain.
Borlongan Cesario V., In PLoS ONE, 2001
... The BAC transgenic mouse line expressing enhanced green fluorescent protein (eGFP) under the DCX promoter was developed within the Gene Expression Nervous System Atlas (GENSAT) BAC Transgenic Project and obtained from ...
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Papers on doublecortin
A novel, clinically relevant use of a piglet model to study the effects of anesthetics on the developing brain.
Christofi et al., Columbus, United States. In Clin Transl Med, 31 Dec 2016
An apparent change in the pattern of doublecortin labeling also suggests changes in neuronal precursors and undifferentiated neurons.
Effects of surgical and chemical castration on spatial learning ability in relation to cell proliferation and apoptosis in hippocampus.
Kim et al., Seoul, South Korea. In Int Urol Nephrol, Feb 2016
To find out the effects of goserelin and bicalutamide with those of orchiectomy in relation to cell proliferation and apoptosis in the hippocampus, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling staining, and immunohistochemistry for 5-bromo-2'-deoxyuridine, doublecortin, and caspase-3 were performed.
Microtubule-binding protein doublecortin-like kinase 1 (DCLK1) guides kinesin-3-mediated cargo transport to dendrites.
Hoogenraad et al., Utrecht, Netherlands. In Embo J, Feb 2016
We found that microtubule-binding protein doublecortin-like kinase 1 (DCLK1) labels a subset of dendritic microtubules and is required for KIF1-dependent dense-core vesicles (DCVs) trafficking into dendrites and dendrite development.
Involvement of BDNF/ERK signaling in spontaneous recovery from trimethyltin-induced hippocampal neurotoxicity in mice.
Moona et al., Kwangju, South Korea. In Brain Res Bull, Feb 2016
In addition, ERK-immunopositive cells were localized predominantly in doublecortin-positive immature progenitor neurons in the DG.
Dominant Expression of DCLK1 in Human Pancreatic Cancer Stem Cells Accelerates Tumor Invasion and Metastasis.
Tanabe et al., Tokyo, Japan. In Plos One, Dec 2015
Microarray and siRNA screening assays showed that doublecortin-like kinase 1 (DCLK1) was predominantly expressed with histone modification in pancreatic CSCs with invasive and metastatic potential.
Endogenous versus exogenous markers of adult neurogenesis in canaries and other birds: advantages and disadvantages.
Ball et al., Liège, Belgium. In J Comp Neurol, 2015
We review here the respective advantages and pitfalls of these different approaches in birds, with specific reference to the microtubule-associated protein, doublecortin (DCX), that has been extensively used to identify young newly born neurons in adult brains.
Cellullar insights into cerebral cortical development: focusing on the locomotion mode of neuronal migration.
Kawauchi, Tokyo, Japan. In Front Cell Neurosci, 2014
The locomoting neurons exhibit unique features; a radial glial fiber-dependent migration requiring the endocytic recycling of N-cadherin and a neuron-specific migration mode with dilation/swelling formation that requires the actin and microtubule organization possibly regulated by cyclin-dependent kinase 5 (Cdk5), Dcx, p27(kip1), Rac1, and POSH.
Genotype-phenotype correlation in neuronal migration disorders and cortical dysplasias.
Kato, Yamagata, Japan. In Front Neurosci, 2014
Mutations of many genes are involved in neuronal migration disorders, such as LIS1 and DCX in classical lissencephaly spectrum, TUBA1A in microlissencephaly with agenesis of the corpus callosum, and RELN and VLDLR in lissencephaly with cerebellar hypoplasia.
Mechanisms of HIV-1 Tat neurotoxicity via CDK5 translocation and hyper-activation: role in HIV-associated neurocognitive disorders.
Masliah et al., San Diego, United States. In Curr Hiv Res, 2014
For this manuscript we review evidence showing that Tat, via calcium dysregulation, promotes calpain-1 cleavage of p35 to p25, which in turn hyper-activates CDK5 resulting in abnormal phosphorylation of downstream targets such as Tau, collapsin response mediator protein-2 [CRMP2], doublecortin [DCX] and MEF2.
Unconventional Functions of Mitotic Kinases in Kidney Tumorigenesis.
Arlot-Bonnemains et al., Rennes, France. In Front Oncol, 2014
Aneuploidy can also result from the loss of cell-cell adhesion and apical-basal cell polarity that also may be regulated by the mitotic kinases (polo-like kinase 1, casein kinase 2, doublecortin-like kinase 1, and Aurora kinases).
Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma.
Dirks et al., Toronto, Canada. In Cancer Cell, 2014
Rare Sox2(+) cells produce rapidly cycling doublecortin(+) progenitors that, together with their postmitotic progeny expressing NeuN, comprise tumor bulk.
Neuroblastoma mRNAs predict outcome in children with stage 4 neuroblastoma: a European HR-NBL1/SIOPEN study.
Burchill et al., London, United Kingdom. In J Clin Oncol, 2014
METHODS: RTqPCR for paired-like homeobox 2b (PHOX2B), tyrosine hydroxylase (TH), and doublecortin (DCX) mRNA in PB and BM of children enrolled onto the High-Risk Neuroblastoma Trial-1 of the European Society of Pediatric Oncology Neuroblastoma Group (HR-NBL1/SIOPEN) was performed at diagnosis and after induction therapy.
Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4.
Kuo et al., Durham, United States. In Nature, 2013
Postnatal/adult neural stem cells (NSCs) within the rodent subventricular zone (SVZ; also called subependymal zone) generate doublecortin (Dcx)(+) neuroblasts that migrate and integrate into olfactory bulb circuitry.
Dclk1 distinguishes between tumor and normal stem cells in the intestine.
Chiba et al., Kyoto, Japan. In Nat Genet, 2013
To identify a potential TSC-specific marker, we focused on doublecortin-like kinase 1 (Dclk1).
Doublecortin and doublecortin-like are expressed in overlapping and non-overlapping neuronal cell population: implications for neurogenesis.
Vreugdenhil et al., Leiden, Netherlands. In J Comp Neurol, 2012
Our findings define doublecortin-like as a novel marker for specific aspects of adult neurogenesis, which partly overlap with DCX
Doublecortin recognizes the 13-protofilament microtubule cooperatively and tracks microtubule ends.
Brouhard et al., Montréal, Canada. In Dev Cell, 2012
DCX binds to polymerization intermediates at growing microtubule ends, in support of a mechanism for stabilizing 13-protofilament microtubules.
Involvement of doublecortin-expressing cells in the arcuate nucleus in body weight regulation.
Schwaninger et al., Lübeck, Germany. In Endocrinology, 2012
Data suggest that doublecortin (DCX) cells in the arcuate nucleus (ARC) represent a cellular correlate of plasticity that is involved in controlling energy balance.
Doublecortin (DCX) mediates endocytosis of neurofascin independently of microtubule binding.
Winckler et al., Charlottesville, United States. In J Neurosci, 2012
This study proposed that DCX acts as an endocytic adaptor for neurofascin to fine-tune its surface distribution during neuronal development.
FLEXIQinase, a mass spectrometry-based assay, to unveil multikinase mechanisms.
Steen et al., Boston, United States. In Nat Methods, 2012
We analyzed the c-Jun N-terminal kinase (JNK)-dependent glycogen synthase kinase 3β (GSK3β) activity on doublecortin (DCX) revealing mechanistic details about the role of phosphorylation cross-talk in GSK3β activity and permitting an advanced model for GSK3β-mediated signaling.
Phosphorylation of doublecortin by protein kinase A orchestrates microtubule and actin dynamics to promote neuronal progenitor cell migration.
Itoh et al., Ikoma, Japan. In J Biol Chem, 2012
Our data reveal a dual reciprocal role for DCX phosphorylation in the regulation of microtubule and actin dynamics that is indispensable for proper brain lamination.
More papers using doublecortin antibodies
Segregation of human neural stem cells in the developing primate forebrain
Couillard-Despres Sebastien et al., In BMC Neuroscience, 2000
... The DCX-CreERT2 construct and the generation of DCX-CreERT2 transgenic mouse ...
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