gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Docking protein 6

DOK-6
DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 [PubMed 15286081]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Dok-1, PTB, Mos, SOCS7, ribosomal protein S20
Papers on DOK-6
Feed intake, average daily gain, feed efficiency, and real-time ultrasound traits in Duroc pigs: II. Genomewide association.
Cassady et al., Raleigh, United States. In J Anim Sci, 2014
A region ranging from166 to 140 Mb (4-Mb length) on SSC 1, approximately 8 Mb upstream of the MC4R gene, was significantly associated with ADFI, ADG, and BF, where SOCS6 and DOK6 are proposed as the most likely candidate genes.
mRNA expression of DOK1-6 in human breast cancer.
Mokbel et al., London, United Kingdom. In World J Clin Oncol, 2014
RESULTS: DOK-2 and DOK-6 expression decreased with increasing TNM stage.
Feed intake, average daily gain, feed efficiency, and real-time ultrasound traits in Duroc pigs: II. Genome-wide association.
Cassady et al., Raleigh, United States. In J Anim Sci, 2014
A region ranging from166-140 Mb (4-Mb length) on SSC 1, approximately 8 Mb upstream MC4R gene, was significantly associated with ADFI, ADG and BF, where SOCS6 and DOK6 are proposed as the most likely candidate genes.
Genetic association for renal traits among participants of African ancestry reveals new loci for renal function.
Fox et al., Boston, United States. In Plos Genet, 2011
In addition, we identified 3 suggestive loci at DOK6 (p-value = 5.3×10(-7)) and FNDC1 (p-value = 3.0×10(-7)) for UACR, and KCNQ1 with eGFR (p = 3.6×10(-6)).
Analysis of DOK-6 function in downstream signaling of RET in human neuroblastoma cells.
GeneRIF
Takahashi et al., Nagoya, Japan. In Cancer Sci, 2010
DOK-6 is involved in RET signaling with less influence when compared with DOK-1, DOK-4, and SHC.
Downstream of tyrosine kinase/docking protein 6, as a novel substrate of tropomyosin-related kinase C receptor, is involved in neurotrophin 3-mediated neurite outgrowth in mouse cortex neurons.
GeneRIF
Peng et al., Beijing, China. In Bmc Biol, 2009
Dok6 selectively binds to the NPQY motif of TrkC through its phosphotyrosine-binding (PTB) domain in a kinase activity-dependent manner.
[Dok6 promote neurite outgrowth of tropomyosin-related kinase C overexpressed PC12 cells in stimulation of neurotrophin-3].
Peng et al., Beijing, China. In Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 2009
OBJECTIVE: To study the role of adaptor protein Dok6 in neurite outgrowth in PC12 cells.
FRA18C: a new aphidicolin-inducible fragile site on chromosome 18q22, possibly associated with in vivo chromosome breakage.
Frank Kooy et al., In J Med Genet, 2007
The break disrupts the DOK6 gene and was immediately followed by a repetitive telomere motif, (TTAGGG)(n).
Nt mutation causing laterality defects associated with deletion of rotatin.
Lo et al., Bethesda, United States. In Mamm Genome, 2007
RT-PCR analysis of known genes in the mapped interval showed no transcripts for four genes, including Rttn, CD226, Dok6, and Txndc10.
Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth.
GeneRIF
Milbrandt et al., Saint Louis, United States. In J Biol Chem, 2004
Dok-6 binds to the phosphorylated Ret Tyr(1062) residue resulting in phosphorylation of tyrosine residue(s) located within the unique C terminus of Dok-6 predominantly through a Src-dependent mechanism
share on facebooktweetadd +1mail to friends