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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Docking protein 4

Dok-4
Top mentioned proteins: Dok-1, Dok5, RET, PTB, CAN
Papers on Dok-4
Canine cutaneous peripheral nerve sheath tumours versus fibrosarcomas can be differentiated by neuroectodermal marker genes in their transcriptome.
Gruber et al., Berlin, Germany. In J Comp Pathol, 2013
Seven of these gene products, known to be specifically expressed in neuroectodermal tissues, had higher expression levels in PNSTs: FMN2, KIF1B, GLI1, ROBO1, NMUR2, DOK4 and HMG20B.
Integrative analysis of microRNA, mRNA and aCGH data reveals asbestos- and histology-related changes in lung cancer.
Knuutila et al., Helsinki, Finland. In Genes Chromosomes Cancer, 2011
In addition, over-expression of the well known squamous cell carcinoma-associated miR-205 was linked to down-regulation of the DOK4 gene.
Molecular karyotypes of Hodgkin and Reed-Sternberg cells at disease onset reveal distinct copy number alterations in chemosensitive versus refractory Hodgkin lymphoma.
Forman et al., Duarte, United States. In Clin Cancer Res, 2011
Gains (>35%) in the HL chemoresponsive patients housed genes known to regulate T-cell trafficking or NF-κB activation (CCL22, CX3CL1, CCL17, DOK4, and IL10), whereas the refractory samples showed frequent loss of 4q27 (interleukin; IL21/IL2) and 17p12, and gain of 19q13.3
Dok4 is involved in Schwann cell myelination and axonal interaction in vitro.
GeneRIF
Decker et al., Paris, France. In Glia, 2011
Dok4 is a novel player in Schwann cell-axon interaction and is required at early stages of myelination; it also aids Schwann cell migration and proliferation.
Expression of microRNA and their gene targets are dysregulated in preinvasive breast cancer.
Rosenberg et al., Boston, United States. In Breast Cancer Res, 2010
Knockdown of the putative oncogenic miRNA miR-182 and miR-183, both highly overexpressed in DCIS, increased the expression of chromobox homolog 7 (CBX7) (which regulates E-cadherin expression), DOK4, NMT2 and EGR1.
Analysis of DOK-6 function in downstream signaling of RET in human neuroblastoma cells.
Takahashi et al., Nagoya, Japan. In Cancer Sci, 2010
The binding affinity of the DOK-6 phosphotyrosine-binding (PTB) domain to RET was much lower than that of the DOK-1, DOK-4, and SHC PTB domains to RET.
Dok-4 is a novel negative regulator of T cell activation.
GeneRIF
Nunès et al., Marseille, France. In J Immunol, 2009
Dok-4 represents a novel negative regulator of T cells
Gene expression profile of the bone microenvironment in human fragility fracture bone.
Fazzalari et al., Adelaide, Australia. In Bone, 2009
Three major sets of differentially expressed genes in OP bone were identified with known or suspected roles in either osteoblast maturation (PRRX1, ANXA2, ST14, CTSB, SPARC, FST, LGALS1, SPP1, ADM, and COL4A1), myelomonocytic differentiation and osteoclastogenesis (TREM2, ANXA2, IL10, CD14, CCR1, ADAM9, CCL2, CTGF, and KLF10), or adipogenesis, lipid and/or glucose metabolism (IL10, MARCO, CD14, AEBP1, FST, CCL2, CTGF, SLC14A1, ANGPTL4, ADM, TAZ, PEA15, and DOK4).
Transcriptional regulation of IRS5/DOK4 expression in non-small-cell lung cancer cells.
GeneRIF
O'Byrne et al., Dublin, Ireland. In Clin Lung Cancer, 2008
Epigenetic regulation of DOK4 expression is associated with non-small-cell lung cancer.
DOK4/IRS-5 expression is altered in clear cell renal cell carcinoma.
GeneRIF
Gray et al., Dublin, Ireland. In Int J Cancer, 2007
IRS-5 (DOK4) is significantly upregulated in 90% of examined clear cell RCCs. Studies on this gene has shown that it is regulated through chromatin remodeling in kidney cells
Endocardiogenesis in embryoid bodies: novel markers identified by gene expression profiling.
Morisaki et al., Suita, Japan. In Biochem Biophys Res Commun, 2007
In those embryos, Gata4 and Nfatc1, as well as newly identified Cgnl1 and Dok4 were found to be preferentially expressed in endocardial cells, but not in yolk sac endothelial cells, while Cdh5 and Kdr were expressed in both cardiac and yolk sac endothelial cells.
A SAGE-based screen for genes expressed in sub-populations of neurons in the mouse dorsal root ganglion.
Carroll et al., Montpellier, France. In Bmc Neurosci, 2006
Several potential markers of sub-populations, Dok4, Crip2 and Grik1/GluR5 were further analyzed by quantitative RT-PCR and double labeling with TrkA,-B,-C, c-ret, parvalbumin and isolectin B4, known markers of DRG neuron sub-types.
Dok-4 regulates GDNF-dependent neurite outgrowth through downstream activation of Rap1 and mitogen-activated protein kinase.
GeneRIF
Takahashi et al., Nagoya, Japan. In J Cell Sci, 2006
Results suggest that Dok-4, through activation of the Rap1-ERK1/2 pathway, regulates GDNF-mediated neurite outgrowth during neuronal development.
Molecular basis of distinct interactions between Dok1 PTB domain and tyrosine-phosphorylated EGF receptor.
He et al., Shanghai, China. In J Mol Biol, 2004
Using yeast two-hybrid and biochemical binding assays, we show that only the PTB domain from Dok1 but not Dok4 or Dok5 can selectively bind to two known tyrosine phosphorylation sites at Y1086 and Y1148 in EGFR.
Pleckstrin homology and phosphotyrosine-binding domain-dependent membrane association and tyrosine phosphorylation of Dok-4, an inhibitory adapter molecule expressed in epithelial cells.
GeneRIF
Lemay et al., Montréal, Canada. In J Biol Chem, 2004
Dok-4 is a constitutively membrane-localized adapter molecule that may function as an inhibitor of tyrosine kinase signaling in epithelial cells.
Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5.
GeneRIF
Shoelson et al., Boston, United States. In J Biol Chem, 2003
IRS5/DOK4 and IRS6/DOK5 represent two new signaling proteins with potential roles in insulin and IGF-1 action
DOK4 and DOK5: new Dok-related genes expressed in human T cells.
GeneRIF
Nunès et al., Marseille, France. In Genes Immun, 2003
DOK4 expression in human T cells has been demonstrated, and its genomic structure has been predicted.
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