Development and application of PI3K assays for novel drug discovery.
Hyderābād, India. In Expert Opin Drug Discov, Feb 2015
INTRODUCTION: Phosphoinositide 3-kinases (PI3Ks) constitute one of the most important signaling pathways, playing a vital role in cellular differentiation and proliferation with a key function in cellular receptor triggered signal transduction downstream of tyrosine kinase receptors and/or G-protein coupled receptors.
Beyond 'furballs' and 'dumpling soups' - towards a molecular architecture of signaling complexes and networks.
Oxford, United Kingdom. In Febs Lett, 2012
Similarly, many growth factor receptors, for example EGF receptor, insulin receptor and c-Met, signal via huge protein complexes built on large platform proteins (Gab, Irs/Dok, p130Cas[BCAR1], Frs families etc.), which are structurally not well understood.