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Dedicator of cytokinesis 1

This gene product binds to the SH3 domain of CRK protein. It may regulate cell surface extension and may have a role in the cell surface extension of an engulfing cell around a dying cell during apoptosis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Akt, Rac1, Actin, ELMO1, Rhodopsin
Papers using DOCK180 antibodies
uPAR promotes formation of the p130Cas–Crk complex to activate Rac through DOCK180
Marshall Christopher J. et al., In The Journal of Cell Biology, 2002
... The following antibodies were used: anti-Rac1 (clone 23A8; Fitzgerald), anti-uPAR (R&D Systems), anti-GAPDH (Novus Biologicals), anti-DOCK180, anti–β3integrin, anti–β1integrin (clone P5D2; Santa Cruz Biotechnology, Inc.), anti–β ...
Papers on DOCK180
Cooperation of distinct Rac-dependent pathways to stabilise E-cadherin adhesion.
Braga et al., London, United Kingdom. In Cell Signal, Sep 2015
To address which activator could mediate E-cadherin signalling to Rac1, we investigated EGFR and two Rac1 GEFs, SOS1 and DOCK180.
Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections.
Notarangelo et al., Worcester, United States. In N Engl J Med, Jul 2015
Results We identified biallelic mutations in the dedicator of cytokinesis 2 gene (DOCK2) in these five patients.
Dedicator of cytokinesis 2, a novel regulator for smooth muscle phenotypic modulation and vascular remodeling.
Chen et al., Fukuoka, Japan. In Circ Res, Jun 2015
OBJECTIVE: The objective of this study is to determine the role of dedicator of cytokinesis 2 (DOCK2) in SMC phenotypic modulation and vascular remodeling.
The bipartite rac1 Guanine nucleotide exchange factor engulfment and cell motility 1/dedicator of cytokinesis 180 (elmo1/dock180) protects endothelial cells from apoptosis in blood vessel development.
Kroll et al., Groningen, Netherlands. In J Biol Chem, Apr 2015
Engulfment and cell motility 1/dedicator of cytokinesis 180 (Elmo1/Dock180) is a bipartite guanine nucleotide exchange factor for the monomeric GTPase Ras-related C3 botulinum toxin substrate 1 (Rac1).
DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation.
Fukui et al., Fukuoka, Japan. In J Immunol, 2015
DOCK2, an atypical guanine nucleotide exchange factor (GEF), is one of the major regulators of Rac in neutrophils.
The SH3 regulatory domain of the hematopoietic cell kinase Hck binds ELMO via its polyproline motif.
Kleman et al., Grenoble, France. In Febs Open Bio, 2014
Eukaryotic EnguLfment and cell MOtility (ELMO) proteins form an evolutionary conserved family of regulators involved in small GTPase dependent actin remodeling processes that regulates the guanine exchange factor activity of some of the Downstream Of CrK (DOCK) family members.
Immune regulatory functions of DOCK family proteins in health and disease.
Fukui et al., Fukuoka, Japan. In Exp Cell Res, 2013
For example, DOCK2, which is predominantly expressed in hematopoietic cells, regulates migration and activation of leukocytes through Rac activation.
Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity.
Bass et al., Boston, United States. In Nat Genet, 2013
The new significantly mutated genes include chromatin-modifying factors and candidate contributors SPG20, TLR4, ELMO1 and DOCK2.
Spontaneous mutation of the Dock2 gene in Irf5-/- mice complicates interpretation of type I interferon production and antibody responses.
Bhattacharya et al., Saint Louis, United States. In Proc Natl Acad Sci U S A, 2012
A spontaneous genomic duplication and frameshift mutation in the guanine exchange factor dedicator of cytokinesis 2 (Dock2) that has arisen in at least a subset of circulating Irf5(-/-) mice and inadvertently been bred to homozygosity.
The C-terminal polyproline-containing region of ELMO contributes to an increase in the life-time of the ELMO-DOCK complex.
Housset et al., Grenoble, France. In Biochimie, 2012
The data demonstrate the ability of the SH3 domain of DOCK180 to interact with ELMO1, regardless of the presence of the polyproline-containing C-terminal end.
Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis.
Cheng et al., Pittsburgh, United States. In Proc Natl Acad Sci U S A, 2012
EGFRvIII (also known as DeltaEGFR and de2-7EGFR), a constitutively active EGFR mutant that is frequently co-overexpressed with EGFR in human glioblastoma, promotes tumorigenesis through Src family kinase (SFK)-dependent phosphorylation of Dock180
Activation of Rac1 by Src-dependent phosphorylation of Dock180(Y1811) mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans.
Cheng et al., Pittsburgh, United States. In J Clin Invest, 2011
Phosphorylation of Dock180(Y1811) enhanced its association with CrkII & p130(Cas). Dock180 associated with PDGFRalpha to promote cell migration. Phosphorylated Dock180(Y1811) contributes to activation of Rac1 in human cancers with PDGFRA amplification.
Overexpression of dedicator of cytokinesis I (Dock180) in ovarian cancer correlated with aggressive phenotype and poor patient survival.
Cheung et al., Hong Kong, Hong Kong. In Histopathology, 2011
Dock180 contributes to ovarian carcinogenesis and dissemination
The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization.
Kanneganti et al., Memphis, United States. In Nat Immunol, 2011
ASC shapes adaptive immunity independently of inflammasomes by modulating Dock2-dependent Rac activation and actin polymerization in DCs and lymphocytes.
Cell intrinsic roles of apoptosis-associated speck-like protein in regulating innate and adaptive immune responses.
Amer et al., Columbus, United States. In Scientificworldjournal, 2010
It has been noted that ASC maintains inflammasome-independent roles, including but not limited to controlling the expression of Dock2 and mitogen-activated protein kinases (MAPK/ERK2) and regulating the NF-κB pathway.
New concepts in phospholipase D signaling in inflammation and cancer.
Gomez-Cambronero, Dayton, United States. In Scientificworldjournal, 2009
PA enriches the localization of the atypical guanine exchange factor (GEF), DOCK2, at the leading edge of polarized neutrophils.
Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis.
Fukui et al., Fukuoka, Japan. In Science, 2009
findings show that intracellular DOCK2 dynamics are sequentially regulated by distinct phospholipids to localize Rac activation during neutrophil chemotaxis
T helper type 2 differentiation and intracellular trafficking of the interleukin 4 receptor-alpha subunit controlled by the Rac activator Dock2.
Fukui et al., Fukuoka, Japan. In Nat Immunol, 2007
Dock2 links T cell receptor signals to downregulation of IL-4Ralpha to control the lineage commitment of CD4+ T cells.
Journey to the grave: signaling events regulating removal of apoptotic cells.
Ravichandran et al., Charlottesville, United States. In J Cell Sci, 2007
Two potential signaling modules have been identified: one involving the CED-12/ELMO and CED-5/Dock180 proteins, which function as a bipartite guanine nucleotide exchange factor (GEF) for Rac1, and a second involving CED-1/LRP1 (a potential engulfment receptor) and the adaptor protein CED-6/GULP.
Programmed cell death.
Xue et al., United States. In Wormbook, 2004
The recognition and removal of the dying cell is mediated by two partially redundant signaling pathways involving CED-1, CED-6 and CED-7 in one pathway and CED-2, CED-5, CED-10, CED-12 and PSR-1 in the other pathway.
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