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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Dedicator of cytokinesis 10

DOCK10, dedicator of cytokinesis 10
Top mentioned proteins: Rhodopsin, GEF, Cdc42, Actin, Rac1
Papers on DOCK10
The RhoGEF DOCK10 is essential for dendritic spine morphogenesis.
Schmidt et al., Montpellier, France. In Mol Biol Cell, Jul 2015
We found a strong increase in the expression of the Cdc42-specific GEF DOCK10.
An epigenetically distinct breast cancer cell subpopulation promotes collective invasion.
Pearson et al., In J Clin Invest, May 2015
Functional analysis determined that DOCK10, ITGA11, DAB2, PDFGRA, VASN, PPAP2B, and LPAR1 are highly expressed in trailblazer cells and required to initiate collective invasion, with DOCK10 essential for metastasis.
Temporal endogenous gene expression profiles in response to lipid-mediated transfection.
Pannier et al., Omaha, United States. In J Gene Med, 2015
RESULTS: Relative to untreated cells 2 h after lipoplex treatment, only downregulated genes were identified ≥ 30-fold: ALMS1, ITGB1, FCGR3A, DOCK10 and ZDDHC13.
Blood transcriptomics of drug-naïve sporadic Parkinson's disease patients.
Gustincich et al., Trieste, Italy. In Bmc Genomics, 2014
Candidate transcripts as CBX5, TCF3, MAN1C1 and DOCK10 were validated by RT-qPCR.
The immunosenescence-related gene Zizimin2 is associated with early bone marrow B cell development and marginal zone B cell formation.
Maruyama et al., Ōbu, Japan. In Immun Ageing, 2014
We also obtained Zizimin3 (Ziz3; Dock10) KO mice and examined the functions of Ziz3.
Dock10, a Cdc42 and Rac1 GEF, induces loss of elongation, filopodia, and ruffles in cervical cancer epithelial HeLa cells.
Parrado et al., Cartagena, Spain. In Biol Open, 2014
Dock10 is one of the three members of the Dock-D family of Dock proteins, a class of guanine nucleotide exchange factors (GEFs) for Rho GTPases.
The role of plasma membrane STIM1 and Ca(2+)entry in platelet aggregation. STIM1 binds to novel proteins in human platelets.
Authi et al., London, United Kingdom. In Cell Signal, 2014
In immunoprecipitation experiments followed by proteomic analysis, STIM1 was found to extract a number of proteins including myosin, DOCK10, thrombospondin-1 and actin.
Prospective diagnostic analysis of copy number variants using SNP microarrays in individuals with autism spectrum disorders.
Depienne et al., Paris, France. In Eur J Hum Genet, 2014
An autosomal recessive cause was considered possible in two patients: a homozygous 1p31.1 deletion encompassing PTGER3 and a deletion of the entire DOCK10 gene associated with a rare hemizygous missense variant.
Transcriptional profiling identifies upregulated genes following induction of epithelial-mesenchymal transition in squamous carcinoma cells.
Kramer et al., San Francisco, United States. In Exp Cell Res, 2012
Some of the strongly upregulated transcripts include genes that are reportedly involved in invasion and metastasis, such as DOCK10, LOX, ROBO1 and SRGN.
Human and mouse DOCK10 splicing isoforms with alternative first coding exon usage are differentially expressed in T and B lymphocytes.
Parrado et al., Murcia, Spain. In Hum Immunol, 2011
T cells and B cells exhibited inverse expression patterns of the DOCK10 isoforms
DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion of melanoma cells.
Marshall et al., London, United Kingdom. In Curr Biol, 2008
Silencing DOCK10 expression in melanoma promotes conversion to mesenchymal migration and is associated with decreased MLC2 phosphorylation and increased Rac1 activation.
Dock10, a novel CZH protein selectively induced by interleukin-4 in human B lymphocytes.
Parrado et al., Cartagena, Spain. In Mol Immunol, 2008
Dock10 could represent a point of convergence for interleukin 4 signalling and small Rho GTPase function in B cells.
Gene expression in poorly differentiated papillary thyroid carcinomas.
Varhaug et al., Bergen, Norway. In Thyroid, 2006
These aggressive tumors were also characterized by overexpression of the integrin ligand periostin, and in some biopsies also of osteopontin and of the upstream Rac-regulator dedicator of cytokinesis 10 (DOCK10).
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