Molecular Pathogenesis of Ehrlichia chaffeensis Infection.
Columbus, United States. In Annu Rev Microbiol, Nov 2015
E. chaffeensis has a multigene family of major outer membrane proteins with porin activity and induces infectious entry using its entry-triggering protein to bind the human cell surface protein DNase X.
Helicobacter pylori HP0425 Targets the Nucleus with DNase I-Like Activity.
Chinju, South Korea. In Helicobacter, Oct 2015
CONCLUSIONS: These results suggest that HP0425 carrying a nuclear localization signal sequence translocates into the nucleus of host cells and degrades genomic DNA by DNase I-like enzymatic activity, which is a new pathogenic strategy of H. pylori in the host.
Regulation of Apoptotic Endonucleases by EndoG.
Little Rock, United States. In Dna Cell Biol, May 2015
The study showed that overexpression of mature EndoG in kidney tubular epithelial NRK-52E cells can increase expression of caspase-activated DNase (CAD) and four endonucleases that belong to DNase I group including DNase I, DNase X, DNase IL2, and DNase γ, but not endonucleases of the DNase 2 group.
[Structure and function of sphingomyelinase].
Tokushima, Japan. In Yakugaku Zasshi, 2009
Based on the highly conserved nature of amino acid residues of the binding sites, the crystal structure of Bc-SMase with Mg(2+) or Co(2+) provided a common structural framework applicable to phosphohydrolases belonging to the DNase I-like folding superfamily.