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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Dynein, axonemal, intermediate chain 2

DNAI2, dynein intermediate chain 2, dynein axonemal intermediate chain 2, Dnaic2
The protein encoded by this gene belongs to the dynein intermediate chain family, and is part of the dynein complex of respiratory cilia and sperm flagella. Mutations in this gene are associated with primary ciliary dyskinesia type 9. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: ICS, MUC5AC, dynactin, HAD, LRRC50
Papers on DNAI2
Identification of the T-complex protein as a binding partner for newly synthesized cytoplasmic dynein intermediate chain 2.
New
Catling et al., New Orleans, United States. In Biochem Biophys Res Commun, Feb 2016
Dynein plays essential roles in intracellular transport of organelles and mitosis, mediated in part by interactions between the dynein intermediate chain 2 (IC-2) subunits and adapter proteins that bind specific cargos.
Role of IFN-γ, IL-13 and IL-17 on mucociliary differentiation of nasal epithelial cells in chronic rhinosinusitis with nasal polyps.
New
Zhang et al., Beijing, China. In Clin Exp Allergy, Oct 2015
Treatment with IFN-γ and IL-13 significantly decreased the expression of β-tubulin IV(specific cilia marker), ciliated cell number and expression of FOXJ1 and DNAI2, in epithelial cultures derived from both CRSwNP patients and control subjects.
Carrier frequencies of eleven mutations in eight genes associated with primary ciliary dyskinesia in the Ashkenazi Jewish population.
New
Zariwala et al., United States. In Mol Genet Genomic Med, Mar 2015
In this report, the carrier frequencies for eleven mutations in eight PCD-associated genes (DNAI1, DNAI2, DNAH5, DNAH11, CCDC114, CCDC40, CCDC65, and C21orf59) that had been found in individuals of Ashkenazi Jewish descent were investigated in order to advise on including them in existing clinical mutation panels for this population.
Ciliary beat pattern and frequency in genetic variants of primary ciliary dyskinesia.
Werner et al., Münster, Germany. In Eur Respir J, 2014
Biallelic mutations (19 novel) were found in 17 genes: DNAI1, DNAI2, DNAH5, DNAH11, CCDC103, ARMC4, KTU/DNAAF2, LRRC50/DNAAF1, LRRC6, DYX1C1, ZMYND10, CCDC39, CCDC40, CCDC164, HYDIN, RSPH4A and RSPH1.
HEATR2 plays a conserved role in assembly of the ciliary motile apparatus.
Mill et al., Leeds, United Kingdom. In Plos Genet, 2014
Immunoprecipitation reveals HEATR2 interacts with DNAI2, but not HSP70 or HSP90, distinguishing it from the client/chaperone functions described for other cytoplasmic proteins required for dynein arm assembly such as DNAAF1-4.
Combined exome and whole-genome sequencing identifies mutations in ARMC4 as a cause of primary ciliary dyskinesia with defects in the outer dynein arm.
Mitchison et al., London, United Kingdom. In J Med Genet, 2014
ARMC4 gene expression is upregulated during ciliogenesis, and we found a predicted interaction with the outer dynein arm protein DNAI2, mutations in which also cause PCD.
Exome sequencing identifies mutations in CCDC114 as a cause of primary ciliary dyskinesia.
Genetic Disorders of Mucociliary Clearance Consortium et al., Chapel Hill, United States. In Am J Hum Genet, 2013
In the remaining 5 individuals with PCD who underwent exome sequencing, we identified mutations in two genes (DNAI2, DNAH5) known to cause PCD, including an Ashkenazi Jewish founder mutation in DNAI2.
Epidermal growth factor stimulates extracellular-signal regulated kinase phosphorylation of a novel site on cytoplasmic Dynein intermediate chain 2.
Catling et al., New Orleans, United States. In Int J Mol Sci, 2012
Using an affinity purification methodology of general utility, here we identify cytoplasmic dynein intermediate chain 2 (DYNC1I-2, IC-2) as a novel substrate for ERK following epidermal growth factor receptor stimulation of fibroblasts.
Binding of dynein intermediate chain 2 to paxillin controls focal adhesion dynamics and migration.
Parker et al., London, United Kingdom. In J Cell Sci, 2012
Using a proteomic approach (two-dimensional fluorescence difference gel electrophoresis), dynein intermediate chain 2 (dynein IC2) was identified as a protein that is phosphorylated inducibly during cell migration in a PKC-regulated manner.
Respiratory syncytial virus inhibits ciliagenesis in differentiated normal human bronchial epithelial cells: effectiveness of N-acetylcysteine.
Cortijo et al., Valencia, Spain. In Plos One, 2011
Our results indicated that RSV induced ultrastructural abnormalities in axonemal basal bodies and decreased the expression of β-tubulin as well as two genes involved in ciliagenesis, FOXJ1 and DNAI2.
Production of transgenic mice by random recombination of targeted genes in female germline stem cells.
Wu et al., Shanghai, China. In J Mol Cell Biol, 2011
The FGSCs from ovaries of 5-day-old and adult mice were isolated and either infected with recombinant viruses carrying green fluorescent protein, Oocyte-G1 or the mouse dynein axonemal intermediate chain 2 gene, or transfected with the Oocyte-G1 specific shRNA expression vector (pRS shOocyte-G1 vector), and then transplanted into infertile mice.
Characterization of the medaka (Oryzias latipes) primary ciliary dyskinesia mutant, jaodori: Redundant and distinct roles of dynein axonemal intermediate chain 2 (dnai2) in motile cilia.
Yokoyama et al., Kyoto, Japan. In Dev Biol, 2010
Positional cloning showed that axonemal dynein intermediate chain 2 (dnai2) is responsible for joi.
Deletions and point mutations of LRRC50 cause primary ciliary dyskinesia due to dynein arm defects.
Omran et al., Freiburg, Germany. In Am J Hum Genet, 2009
Functional analyses showed that LRRC50 deficiency disrupts assembly of distally and proximally DNAH5- and DNAI2-containing ODA complexes, as well as DNALI1-containing IDA complexes, resulting in immotile cilia.
Identification of DH IC-2 as a HIF-1 independent protein involved in the adaptive response to hypoxia in tumor cells: A putative role in metastasis.
Michiels et al., Namur, Belgium. In Biochim Biophys Acta, 2009
We show that the cytoplasmic dynein intermediate chain 2 (DH IC-2), a component of an intracellular ATPase minus-end directed tubulin-based motile complex, was stabilized and post-translationally modified under hypoxia in a HIF-1 independent way.
Ciliary defects and genetics of primary ciliary dyskinesia.
Review
Amselem et al., Paris, France. In Paediatr Respir Rev, 2009
The relative contribution of DNAI2 is currently being assessed.
DNAI2 mutations cause primary ciliary dyskinesia with defects in the outer dynein arm.
GeneRIF
Omran et al., Freiburg, Germany. In Am J Hum Genet, 2008
DNAI2 mutations cause primary ciliary dyskinesia with defects in the outer dynein arm.
Mouse dynein axonemal intermediate chain 2: cloning and expression.
GeneRIF
Wu et al., Shanghai, China. In Dna Cell Biol, 2008
These data suggest that Dnaic2 plays a role in ovarian follicular development.
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