Targeting DNA-PKcs and telomerase in brain tumour cells.
Singapore, Singapore. In Mol Cancer, Dec 2013
Phosphorylation status of DNA-PKcs was measured with immunoblotting and effects on cell proliferation were monitored with cell titre glow and trypan blue exclusion following dual inhibition.
Tel2 regulates the stability of PI3K-related protein kinases.
New York City, United States. In Cell, 2008
The effects of Tel2 deletion correlated with significantly reduced protein levels for the PI3K-related kinases ataxia telangiectasia mutated (ATM), ATM and Rad3 related (ATR), DNA-dependent protein kinase catalytic subunit ataxia (DNA-PKcs).