Regulation of DNA repair by S-nitrosylation.
San Francisco, United States. In Biochim Biophys Acta, 2012
MAJOR CONCLUSIONS: Recent studies have identified a number of key DNA repair proteins as targets of S-nitrosylation, including O(6)-alkylguanine-DNA-alkyltransferase (AGT), 8-oxoguanine glycosylase, apurinic-apyrimidinic endonuclease 1, and DNA-dependent protein kinase catalytic subunit.
More forks on the road to replication stress recovery.
Fort Collins, United States. In J Mol Cell Biol, 2011
In recent years, several proteins involved in DSB repair by non-homologous end joining (NHEJ) have been implicated in the replication stress response, including DNA-PKcs, Ku, DNA Ligase IV-XRCC4, Artemis, XLF and Metnase.
Tel2 regulates the stability of PI3K-related protein kinases.
New York City, United States. In Cell, 2008
The effects of Tel2 deletion correlated with significantly reduced protein levels for the PI3K-related kinases ataxia telangiectasia mutated (ATM), ATM and Rad3 related (ATR), DNA-dependent protein kinase catalytic subunit ataxia (DNA-PKcs).