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Primase, DNA, polypeptide 1

DNA Primase, p49, Strap
The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the small, 49 kDa primase subunit. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: POLYMERASE, CAN, ACID, HAD, OUT
Papers on DNA Primase
A transcriptional miRNA-gene network associated with lung adenocarcinoma metastasis based on the TCGA database.
He et al., Chongqing, China. In Oncol Rep, Feb 2016
Our data suggested that some of the genes including PKM2, STRAP and FLT3, may participate in the pathology of lung adenocarcinoma metastasis and could be applied as potential markers or therapeutic targets for lung adenocarcinoma.
The LMO2 oncogene regulates DNA replication in hematopoietic cells.
Hoang et al., Toulouse, France. In Proc Natl Acad Sci U S A, Feb 2016
Here, we show that LMO2 is recruited to DNA replication origins by interaction with three essential replication enzymes: DNA polymerase delta (POLD1), DNA primase (PRIM1), and minichromosome 6 (MCM6).
Insight into the Human DNA Primase Interaction with Template-primer.
Tahirov et al., United States. In J Biol Chem, Jan 2016
UNASSIGNED: DNA replication in almost all organisms depends on the activity of DNA primase, a DNA-dependent RNA polymerase that synthesizes short RNA primers of defined size for DNA polymerases.
Ankle-Dorsiflexion Range of Motion After Ankle Self-Stretching Using a Strap.
Hwang et al., Wŏnju, South Korea. In J Athl Train, Dec 2015
A strap can be applied to stabilize the talus and facilitate anterior glide of the distal tibia at the talocrural joint during ankle self-stretching exercises.
Changes of Plantar Pressure and Gait Parameters in Children with Mild Cerebral Palsy Who Used a Customized External Strap Orthosis: A Crossover Study.
Lai et al., Wuxue, China. In Biomed Res Int, 2014
A customized external strap orthosis for correcting leg alignment was used to resolve this problem.
IVisTMSA: Interactive Visual Tools for Multiple Sequence Alignments.
Javed et al., Lahore, Pakistan. In Evol Bioinform Online, 2014
It can load 409% more data than Jalview, STRAP, CINEMA, and Base-by-Base.
Minireview: DNA replication in plant mitochondria.
Nielsen et al., Provo, United States. In Mitochondrion, 2014
Several plant mtDNA replication proteins, including DNA polymerases, DNA primase/helicase, and accessory proteins have been identified.
Enzymes involved in organellar DNA replication in photosynthetic eukaryotes.
Sato et al., Tokyo, Japan. In Front Plant Sci, 2013
Although the replication mechanisms of these organellar genomes remain unclear in photosynthetic eukaryotes, several organelle-localized enzymes related to genome replication, including DNA polymerase, DNA primase, DNA helicase, DNA topoisomerase, single-stranded DNA maintenance protein, DNA ligase, primer removal enzyme, and several DNA recombination-related enzymes, have been identified.
Monitoring regulation of DNA repair activities of cultured cells in-gel using the comet assay.
Parsons et al., Liverpool, United Kingdom. In Front Genet, 2013
For example, we have shown that the E3 ubiquitin ligase Mule, the tumor suppressor protein ARF, and the deubiquitylation enzyme USP47 modulate DNA repair by controlling cellular levels of DNA polymerase β, and also that polynucleotide kinase phosphatase levels are controlled by ATM-dependant phosphorylation and Cul4A-DDB1-STRAP-dependent ubiquitylation.
A conserved motif in the C-terminal tail of DNA polymerase α tethers primase to the eukaryotic replisome.
Pellegrini et al., Cambridge, United Kingdom. In J Biol Chem, 2012
Findings indicate that tethering of DNA primase Prim1 to the replisome by DNA polymerase alpha (pol alpha) is critical for the normal action of DNA replication forks in eukaryotic cells.
Bacterial DNA replication enzymes as targets for antibacterial drug discovery.
Doig et al., Waltham, United States. In Expert Opin Drug Discov, 2012
For DNA primase, DNA helicase and other replisome targets, with the exception of DNA ligase, the exploitation of structure for lead generation has not been tested to the same extent that it has for DNA gyrase.
The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure.
Bullock et al., Oxford, United Kingdom. In Proc Natl Acad Sci U S A, 2012
both of the TPR and OB-fold domains localize to the chromatin of p53 target genes and exhibit intrinsic regulatory activity necessary for the Strap-dependent p53 response
Role of STRAP in regulating GSK3β function and Notch3 stabilization.
Datta et al., Nashville, United States. In Cell Cycle, 2011
STRAP protein decreases ubiquitination of intracellular domain of Notch3 and may help to stabilize it.
STRAP regulates c-Jun ubiquitin-mediated proteolysis and cellular proliferation.
Datta et al., Nashville, United States. In Biochem Biophys Res Commun, 2011
STRAP regulates c-Jun stability by decreasing the ubiquitylation and proteosomal degradation of c-Jun.
B-MYB positively regulates serine-threonine kinase receptor-associated protein (STRAP) activity through direct interaction.
Ha et al., Ch'ŏngju, South Korea. In J Biol Chem, 2011
B-MYB acts as a positive regulator of STRAP
Magic spots cast a spell on DNA primase.
Keck et al., Madison, United States. In Cell, 2007
In this issue, Wang et al. (2007) show that (p)ppGpp also inhibits DNA replication elongation by interfering with DNA primase activity.
DNA primase acts as a molecular brake in DNA replication.
van Oijen et al., Boston, United States. In Nature, 2006
A hallmark feature of DNA replication is the coordination between the continuous polymerization of nucleotides on the leading strand and the discontinuous synthesis of DNA on the lagging strand.
A new effector pathway links ATM kinase with the DNA damage response.
La Thangue et al., Glasgow, United Kingdom. In Nat Cell Biol, 2004
Here we report a new pathway in which ATM kinase signals the DNA damage response by targeting the transcriptional cofactor Strap.
Replisome-mediated DNA replication.
Salinas et al., United States. In Annu Rev Biochem, 2000
The components of the replication complex can be grouped into functional categories as follows: DNA polymerase, helix destabilizing protein, polymerase accessory factors, and primosome (DNA helicase and DNA primase activities).
Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases alpha and delta.
Gottschling et al., Chicago, United States. In Cell, 2000
Telomere addition was detected in M phase arrested cells, which permitted us to determine that the essential DNA polymerases alpha and delta and DNA primase were required.
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