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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Polymerase , gamma

DNA polymerase gamma
Top mentioned proteins: POLYMERASE, CAN, ACID, HAD, AGE
Papers on DNA polymerase gamma
Zebrafish lacking functional DNA polymerase gamma survive to juvenile stage, despite rapid and sustained mitochondrial DNA depletion, altered energetics and growth.
New
Chan et al., Charleston, United States. In Nucleic Acids Res, Jan 2016
DNA polymerase gamma (POLG) is essential for replication and repair of mitochondrial DNA (mtDNA).
A Clinical, Neuropathological and Genetic Study of Homozygous A467T POLG-Related Mitochondrial Disease.
New
Rahman et al., London, United Kingdom. In Plos One, Dec 2015
Mutations in the nuclear gene POLG (encoding the catalytic subunit of DNA polymerase gamma) are an important cause of mitochondrial disease.
Role of the Mitochondrial RNA Polymerase in the Toxicity of Nucleotide Inhibitors of the Hepatitis C Virus.
New
Ray et al., Foster City, United States. In Antimicrob Agents Chemother, Dec 2015
In conclusion, analogous to the role of mitochondrial DNA polymerase gamma in toxicity caused by some 2' -deoxynucleotide analogs, there is an association between HCV NI that interact with POLRMT and the observation of adverse events.
Mitochondrial DNA Polymerase POLG1 Disease Mutations and Germline Variants Promote Tumorigenic Properties.
Singh et al., Birmingham, United States. In Plos One, 2014
Germline mutations in mitochondrial DNA polymerase gamma (POLG1) induce mitochondrial DNA (mtDNA) mutations, depletion, and decrease oxidative phosphorylation.
Searching for association of the CAG repeat polymorphism in the mitochondrial DNA polymerase gamma gene (POLG) with colorectal cancer.
Grzybowski et al., Bydgoszcz, Poland. In Acta Biochim Pol, 2014
Mitochondrial DNA polymerase gamma (POLG) is the only DNA polymerase involved in maintaining the mitochondrial genome.
Inherited peripheral neuropathies due to mitochondrial disorders.
Review
Funalot et al., Angers, France. In Rev Neurol (paris), 2014
This is the case in several syndromes caused by impaired mtDNA maintenance, such as Sensory Ataxic Neuropathy, Dysarthria and Ophthalmoplegia (SANDO) due to recessive mutations in the POLG gene, which encodes the catalytic subunit of mtDNA polymerase (DNA polymerase gamma), or Mitochondrial Neuro-Gastro-Intestinal Encephalomyopathy (MNGIE), due to recessive mutations in the TYMP gene, which encodes thymidine phosphorylase.
Animal models of human mitochondrial DNA mutations.
Review
Pinkert et al., Auburn, United States. In Biochim Biophys Acta, 2012
Animals derived from spontaneous mtDNA mutations, somatic cell nuclear transfer (SCNT), nuclear translocation of mitochondrial genes followed by mitochondrial protein targeting (allotopic expression), mutations in mitochondrial DNA polymerase gamma, direct microinjection of exogenous mitochondria, and cytoplasmic hybrid (cybrid) embryonic stem cells (ES cells) containing exogenous mitochondria (transmitochondrial cells) are considered.
Mitochondrial syndromes with leukoencephalopathies.
Review
Wong, Houston, United States. In Semin Neurol, 2012
Defects in a group of nuclear genes involved in the maintenance of mtDNA integrity may also affect the white matter; for example, mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) caused by thymidine phosphorylase deficiency, Navajo neurohepatopathy (NNH) due to MPV17 mutations, and Alpers syndrome due to defects in DNA polymerase gamma (POLG).
Mitochondrial toxicity in HAART: an overview of in vitro evidence.
Review
Esplugues et al., Valencia, Spain. In Curr Pharm Des, 2010
The mitochondrial effect of N(t)RTI (Nucleos(t)ide Reverse Transcriptase Inhibitors) class of drugs, which has been widely studied, is believed to originate from the inhibitory action of these drugs on DNA polymerase gamma, the enzyme responsible for replication of mitochondrial DNA.
[DNA polymerases beta and lambda, and their roles in the DNA replication and repair].
Review
Lavrik et al., In Mol Biol (mosk), 2010
Mitochondrial DNA polymerase gamma from A family and most of the nuclear enzymes from B family are high fidelity DNA polymerases which are participate in genome DNA replication process as well as in DNA repair.
A crucial role of mitochondrial Hsp40 in preventing dilated cardiomyopathy.
Impact
Lee et al., Los Angeles, United States. In Nat Med, 2006
Profiling of Dnaja3-interacting proteins identified the alpha-subunit of DNA polymerase gamma (Polga) as a client protein.
Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: clinical and molecular genetic study.
Impact
Suomalainen et al., Helsinki, Finland. In Lancet, 2004
BACKGROUND: Mutations in the gene encoding mitochondrial DNA polymerase gamma (POLG), the enzyme that synthesises mitochondrial DNA (mtDNA), have been associated with a mitochondrial disease-autosomal dominant or recessive progressive external ophthalmoplegia-and multiple deletions of mtDNA.
DNA polymerase gamma, the mitochondrial replicase.
Review
Impact
Kaguni, East Lansing, United States. In Annu Rev Biochem, 2003
DNA polymerase (pol) gamma is the sole DNA polymerase in animal mitochondria.
Changes in mitochondrial DNA as a marker of nucleoside toxicity in HIV-infected patients.
Impact
Montaner et al., Vancouver, Canada. In N Engl J Med, 2002
BACKGROUND: Nucleoside analogues can induce toxic effects on mitochondria by inhibiting the human DNA polymerase gamma.
Primers for mitochondrial DNA replication generated by endonuclease G.
Impact
Ruiz-Carrillo et al., Qu├ębec, Canada. In Science, 1993
The cleavage sites match those found in vivo, indicating that Endo G is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA.
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