DNA polymerase beta
Cellular roles of DNA polymerase beta.
New Haven, United States. In Yale J Biol Med, 2013
Since its discovery and purification in 1971, DNA polymerase ß (Pol ß) is one of the most well-studied DNA polymerases.
Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends.
Chapel Hill, United States. In Nature, 2010
At single-strand breaks, 5'-terminal abasic sites are excised by the 5'-deoxyribose-5-phosphate (5'-dRP) lyase activity of DNA polymerase beta (pol beta): here we show, in vitro and in cells, that accurate and efficient repair by NHEJ of double-strand breaks with such damage similarly requires 5'-dRP/AP lyase activity.