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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Polymerase , beta

DNA polymerase beta
Top mentioned proteins: POLYMERASE, CAN, ACID, GAP, STEP
Papers on DNA polymerase beta
Gastric cancer associated variant of DNA polymerase beta (Leu22Pro) promotes DNA replication associated double strand breaks.
New
Kidane et al., Austin, United States. In Oncotarget, Oct 2015
DNA polymerase beta (Pol β) is a key enzyme for the protection against oxidative DNA lesions via its role in base excision repair (BER).
Expression, purification, and biochemical characterization of recombinant DNA polymerase beta of the Trypanosoma cruzi TcI lineage: requirement of additional factors and detection of phosphorylation of the native form.
New
Venegas et al., Santiago, Chile. In Parasitol Res, Apr 2015
Among the possible chemotherapeutic targets that could be considered for study in T. cruzi are the DNA polymerases, in particular DNA polymerase beta (polß), which previous studies have shown to be involved in kinetoplast DNA replication and repair.
Clinical significance of a point mutation in DNA polymerase beta (POLB) gene in gastric cancer.
Lu et al., Washington, D.C., United States. In Int J Biol Sci, 2014
We have previously identified a T to C point mutation at nucleotide 889 (T889C) in DNA polymerase beta (POLB) gene, a key enzyme involved in base excision repair in primary GCs.
HeLa Cells Containing a Truncated Form of DNA Polymerase Beta are More Sensitized to Alkylating Agents than to Agents Inducing Oxidative Stress.
Bhattacharyya et al., Medinīpur, India. In Asian Pac J Cancer Prev, 2014
The present study was aimed at determining the effects of alkylating and oxidative stress inducing agents on a newly identified variant of DNA polymerase beta (polβ Δ208-304) specific for ovarian cancer.
Cell cycle regulation of DNA polymerase beta in rotenone-based Parkinson's disease models.
Wang et al., Binzhou, China. In Plos One, 2013
In Parkinson's disease (PD), neuronal cells undergo mitotic catastrophe and endoreduplication prior to cell death; however, the regulatory mechanisms remain to be defined.
Cellular roles of DNA polymerase beta.
Review
Sweasy et al., New Haven, United States. In Yale J Biol Med, 2013
Since its discovery and purification in 1971, DNA polymerase ß (Pol ß) is one of the most well-studied DNA polymerases.
DNA polymerase beta (pol β) inhibitors: a comprehensive overview.
Review
Tuszynski et al., Edmonton, Canada. In Drug Discov Today, 2012
Among the essential enzymes that are required to achieve the BER reaction is DNA polymerase beta (pol β), which has been regarded as a potential therapeutic target.
Down syndrome as a model of DNA polymerase beta haploinsufficiency and accelerated aging.
Review
Cabelof et al., Denver, United States. In Mech Ageing Dev, 2012
Further, we have reviewed the role that loss of BER, specifically DNA polymerase beta, plays in accelerating the rate of aging.
DNA repair inhibitors: the next major step to improve cancer therapy.
Review
Tuszynski et al., Edmonton, Canada. In Curr Top Med Chem, 2011
These are Excision Repair Cross-Complementation Group 1 (ERCC1), and DNA polymerase beta (pol β).
A review of recent experiments on step-to-step "hand-off" of the DNA intermediates in mammalian base excision repair pathways.
Review
Wilson et al., United States. In Mol Biol (mosk), 2011
The results show that when base excision repair enzymes are pre-bound to the initial single-nucleotide base excision repair intermediate, the DNA is channeled from apurinic/apyrimidinic endonuclease 1 to DNA polymerase beta and then to DNA ligase.
Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends.
Impact
Ramsden et al., Chapel Hill, United States. In Nature, 2010
At single-strand breaks, 5'-terminal abasic sites are excised by the 5'-deoxyribose-5-phosphate (5'-dRP) lyase activity of DNA polymerase beta (pol beta): here we show, in vitro and in cells, that accurate and efficient repair by NHEJ of double-strand breaks with such damage similarly requires 5'-dRP/AP lyase activity.
Crystal structure of the catalytic alpha subunit of E. coli replicative DNA polymerase III.
Impact
Kuriyan et al., Berkeley, United States. In Cell, 2006
The crystal structure, determined at 2.3 A resolution, of a large fragment of Pol III (residues 1-917), reveals a unique chain fold with localized similarity in the catalytic domain to DNA polymerase beta and related nucleotidyltransferases.
Crystal structures of the Bacillus stearothermophilus CCA-adding enzyme and its complexes with ATP or CTP.
Impact
Steitz et al., New Haven, United States. In Cell, 2003
The head is structurally homologous to the palm domain of DNA polymerase beta but has additional structural features and functions.
An exonucleolytic activity of human apurinic/apyrimidinic endonuclease on 3' mispaired DNA.
Impact
Cheng et al., New Haven, United States. In Nature, 2002
Human apurinic/apyrimidinic endonuclease (APE1) is an essential enzyme in DNA base excision repair that cuts the DNA backbone immediately adjacent to the 5' side of abasic sites to facilitate repair synthesis by DNA polymerase beta (ref.
Crystal structure of a pol alpha family replication DNA polymerase from bacteriophage RB69.
Impact
Steitz et al., New Haven, United States. In Cell, 1997
Although its palm domain has the same topology as other polymerases, except rat DNA polymerase beta, one of the three carboxylates required for nucleotidyl transfer is located on a different beta strand.
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