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POLA2 polymerase (DNA directed), alpha 2 (70kD subunit)

DNA polymerase alpha subunit
Top mentioned proteins: POLYMERASE, OUT, Inactive, SET, fibrillin-1
Papers on DNA polymerase alpha subunit
Efficient identification of mutated cancer antigens recognized by T cells associated with durable tumor regressions.
Robbins et al., Israel. In Clin Cancer Res, 2014
In contrast, screening of tandem minigene libraries encoding tumor-specific mutations resulted in the identification of mutated kinesin family member 2C (KIF2C) antigen as a target of TIL 2359, and mutated DNA polymerase alpha subunit B (POLA2) antigen as a target of TIL 2591.
Novel SNP improves differential survivability and mortality in non-small cell lung cancer patients.
Tong et al., In Bmc Genomics, 2013
The single nucleotide polymorphism (SNP) causes DNA polymerase alpha subunit B to localize in the cytoplasm instead of the nucleus.
In vitro antifungal activity of synthetic dsRNA molecules against two pathogens of banana, Fusarium oxysporum f. sp. cubense and Mycosphaerella fijiensis.
Bailey et al., Kampala, Uganda. In Pest Manag Sci, 2013
CONCLUSION: The dsRNAs for adenylate cyclase, DNA polymerase alpha subunit and DNA polymerase delta subunit showed high levels of spore germination inhibition during both self- and cross-species tests, making them the most promising targets for RNA-mediated resistance in banana against these fungal pathogens.
Aberrant DNA polymerase alpha is excluded from the nucleus by defective import and degradation in the nucleus.
Hanaoka et al., Wako, Japan. In J Biol Chem, 2009
Due to a single point mutation in the largest DNA polymerase alpha subunit, p180, the temperature-sensitive mouse cell line tsFT20 exhibits heat-labile DNA polymerase alpha activity and S phase arrest at restrictive temperature.
The effects of 1alpha,25-dihydroxyvitamin D3 on the expression of DNA replication genes.
Verstuyf et al., Leuven, Belgium. In J Bone Miner Res, 2004
RESULTS AND CONCLUSIONS: After 12 h of treatment, in parallel with the 1,25(OH)2D3-induced G1 arrest, a particular set of DNA replication genes including a cell division cycle 6 homolog, a DNA polymerase alpha subunit, proliferating cell nuclear antigen, two DNA polymerase delta subunits, and flap-structure specific endonuclease 1, was downregulated at least 2-fold.
Replication fork reversal in DNA polymerase III mutants of Escherichia coli: a role for the beta clamp.
Michel et al., Jouy-le-Moutier, France. In Mol Microbiol, 2002
In the dnaEts recB strain, RuvABC-dependent DSBs caused by the dnaEts mutation occurred at 37 degrees C or 42 degrees C, indicating the occurrence of replication fork reversal upon partial or complete inactivation of the DNA polymerase alpha subunit.
Deoxypyrimidine cluster mediates the priming by calf thymus DNA primase subunit.
Yoshida et al., Nagoya, Japan. In Biochem Mol Biol Int, 1993
Homogeneously purified DNA polymerase alpha subunit-free primase was used to analyze primer RNA synthesis.
Physical association of the human base-excision repair enzyme uracil DNA glycosylase with the 70,000-dalton catalytic subunit of DNA polymerase alpha.
Sirover et al., In Proc Natl Acad Sci U S A, 1986
The suspicion that the two proteins were physically associated was confirmed by finding that, on mixing the DNA polymerase alpha subunit with the glycosylase, the latter was strongly inhibited by our monoclonal antibody.
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