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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

DNA

DNA methyltransferase, DNMT1, DNA methyltransferase 1, DNMT
DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] (from NCBI)
Top mentioned proteins: CAN, Histone, Methylguanine-DNA Methyltransferase, V1a, HAD
Papers using DNA methyltransferase antibodies
Arsenic trioxide inhibits DNA methyltransferase and restores methylation-silenced genes in human liver cancer cells.
Supplier
Aboussekhra Abdelilah, In PLoS ONE, 2005
... and GAPDH were obtained from NeoMarkers (Fremont, CA, USA), and the mouse monoclonal antibodies against DNMT1,DNMT3a and DNMT3b was obtained from Abnova (Taipei, Taiwan) ...
RNA interference-mediated knockdown of DNA methyltransferase 1 leads to promoter demethylation and gene re-expression in human lung and breast cancer cells
Supplier
Rasti Mozhgan et al., In Iranian Journal of Medical Sciences, 2003
... The primary antibodies including anti-DNMT1 (Abcam, Canada) and anti-actin (Abcam, ...
Recombinant human DNA (cytosine-5) methyltransferase II. Steady-state kinetics reveal allosteric activation by methylated DNA
Supplier
Roach Peter L. et al., In Nucleic Acids Research, 1998
... Restriction endonuclease GlaI was purchased from SE Technologies (Zweibrücken, Germany), M.SssI and human DNMT1 were obtained from New England Biolabs (Herts., UK) ...
Papers on DNA methyltransferase
Glycolic Acid Silences Inflammasome Complex Genes, NLRC4 and ASC, by Inducing DNA Methylation in HaCaT Cells.
New
Yang et al., Taiwan. In Dna Cell Biol, Feb 2016
Methylation changes were detected in these genes following treatment with DNA methyltransferase (DNMT) inhibitor 5-aza-2'-deoxycytidine (5-Aza) with or without the addition of GA using methylation-specific PCR (MSP).
Common BRAF(V600E)-directed pathway mediates widespread epigenetic silencing in colorectal cancer and melanoma.
New
Green et al., Worcester, United States. In Proc Natl Acad Sci U S A, Feb 2016
Promoter-bound MAFG recruits a set of corepressors that includes its heterodimeric partner BTB and CNC homology 1, basic leucine zipper transcription factor 1 (BACH1), the chromatin remodeling factor chromodomain helicase DNA-binding protein 8 (CHD8), and the DNA methyltransferase DNMT3B, resulting in hypermethylation and transcriptional silencing.
Programmed Hyperphagia in Offspring of Obese Dams: Altered Expression of Hypothalamic Nutrient Sensors, Neurogenic Factors and Epigenetic Modulators.
New
Ross et al., Torrance, United States. In Appetite, Feb 2016
We determined the protein expression of energy sensors (mTOR, pAMPK), epigenetic factors (DNA methylase, DNMT1; histone deacetylase, SIRT1/HDAC1), neurogenic factors (Hes1, Mash1, Ngn3) and appetite/satiety neuropeptides (AgRP/POMC) in newborn hypothalamus and adult arcuate nucleus (ARC).
Emodin enhances the demethylation by 5-Aza-CdR of pancreatic cancer cell tumor-suppressor genes P16, RASSF1A and ppENK.
New
Chen et al., Jiaxing, China. In Oncol Rep, Feb 2016
In contrast, the expression levels of DNA methyltransferase 1 (DNMT1) and DNMT3a were more significantly reduced with the combination treatment than the control or either agent alone, further proving that emodin in combination with 5-Aza-CdR enhanced the demethylation effect of 5-Aza-CdR by reducing the expression of methyltransferases.
Lead neurotoxicity: exploring the potential impact of lead substitution in zinc-finger proteins on mental health.
Review
New
Austin et al., Lewiston, United States. In Metallomics, Feb 2016
The zinc-finger proteins potentially impacted by lead include DNA methyltransferase 1 (DNMT1) and Presenilin 1 and 2 (PSEN1/2) in Alzheimer's disease, the dopamine receptor in Parkinson's disease, and the NMDA receptor, zinc-finger protein 804A (ZNF804A), and disrupted-in-schizophrenia 1 (DISC1)-binding zinc-finger (DBZ) in schizophrenia.
Are epigenetic drugs for diabetes and obesity at our door step?
Review
New
Choudhury et al., Kingsville, United States. In Drug Discov Today, Jan 2016
These classes include histone deacetylase inhibitors (HDACi), histone acetyltransferase inhibitors (HATi), protein arginine methyltransferase inhibitors (PRMTis), DNA methyltransferase inhibitors (DNMTis), histone demethylating inhibitors (HDMis), and sirtuin-activating compounds (STACs).
Epigenetic Dysregulation in Virus-Associated Neoplasms.
Review
New
Niller et al., Szeged, Hungary. In Adv Exp Med Biol, Dec 2015
In hepatoma cells expressing HBx, the oncoprotein encoded by the HBV genome, demethylation of the repetitive satellite 2 sequences was observed, due to downregulation of the de novo DNA methyltransferase DNMT3B.
Stress Response Leading to Resistance in Glioblastoma-The Need for Innovative Radiotherapy (iRT) Concepts.
Review
New
Multhoff et al., München, Germany. In Cancers (basel), Dec 2015
Further molecular alterations and prognostic markers like the DNA-repair protein O6-methylguanine-DNA methyltransferase (MGMT), anti-apoptotic molecular chaperones, and/or the activity of aldehyde dehydrogenase 1 (ALDH1) have also been identified to play a role in the sensitivity to cytostatic agents.
Investigating molecular alterations to profile short- and long-term recurrence-free survival in patients with primary glioblastoma.
New
Naccarato et al., Pisa, Italy. In Oncol Lett, Dec 2015
The 19 samples were molecularly characterized for mutations in the isocitrate dehydrogenase 1 (IDH1) gene, amplification of the epidermal growth factor receptor (EGFR) gene, presence of the EGFR variant III, and methylation of the promoter region of the O(6)-methylguanine-DNA methyltransferase (MGMT) gene.
Myeloproliferative neoplasms: Current molecular biology and genetics.
Review
New
Saeidi, Kermān, Iran. In Crit Rev Oncol Hematol, Dec 2015
Some other genes' location such as TET oncogene family member 2 (TET2), additional sex combs-like 1 (ASXL1), casitas B-lineage lymphoma proto-oncogene (CBL), isocitrate dehydrogenase 1/2 (IDH1/IDH2), IKAROS family zinc finger 1 (IKZF1), DNA methyltransferase 3A (DNMT3A), suppressor of cytokine signaling (SOCS), enhancer of zeste homolog 2 (EZH2), tumor protein p53 (TP53), runt-related transcription factor 1 (RUNX1) and high mobility group AT-hook 2 (HMGA2) have also identified to be involved in MPNs phenotypes.
Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy.
New
Impact
Zou et al., Ann Arbor, United States. In Nature, Dec 2015
Using human ovarian cancers as our model, here we show that enhancer of zeste homologue 2 (EZH2)-mediated histone H3 lysine 27 trimethylation (H3K27me3) and DNA methyltransferase 1 (DNMT1)-mediated DNA methylation repress the tumour production of T helper 1 (TH1)-type chemokines CXCL9 and CXCL10, and subsequently determine effector T-cell trafficking to the tumour microenvironment.
MSC Transplantation Improves Osteopenia via Epigenetic Regulation of Notch Signaling in Lupus.
New
Impact
Shi et al., Philadelphia, United States. In Cell Metab, Nov 2015
Mechanistically, we show that Fas deficiency causes failure of miR-29b release, thereby elevating intracellular miR-29b levels, and downregulates DNA methyltransferase 1 (Dnmt1) expression in MRL/lpr BMMSCs.
Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses.
New
Impact
Strick et al., Baltimore, United States. In Cell, Sep 2015
We show that DNA methyltransferase inhibitors (DNMTis) upregulate immune signaling in cancer through the viral defense pathway.
DNA Methylation on N6-Adenine in C. elegans.
New
Impact
Shi et al., Boston, United States. In Cell, Jun 2015
Importantly, we identify a DNA demethylase, NMAD-1, and a potential DNA methyltransferase, DAMT-1, which regulate 6mA levels and crosstalk between methylations of histone H3K4 and adenines and control the epigenetic inheritance of phenotypes associated with the loss of the H3K4me2 demethylase spr-5.
Of Mice and Man: Differential DNMT Dependence in Mammalian ESCs.
New
Impact
Lister et al., Perth, Australia. In Cell Stem Cell, Jun 2015
(2015) recently reported on the effects of disrupting DNA methyltransferase activity in human embryonic stem cells (hESCs).
DNMT1-mediated PTEN hypermethylation confers hepatic stellate cell activation and liver fibrogenesis in rats.
GeneRIF
Li et al., Hefei, China. In Toxicol Appl Pharmacol, 2012
DNMT1-mediated PTEN hypermethylation confers hepatic stellate cell activation and liver fibrogenesis in rats
Oct4 and Nanog directly regulate Dnmt1 to maintain self-renewal and undifferentiated state in mesenchymal stem cells.
GeneRIF
Hung et al., Taipei, Taiwan. In Mol Cell, 2012
Oct4 and Nanog directly regulate Dnmt1 to maintain self-renewal and undifferentiated state in mesenchymal stem cells
Pregnancy and the methyltransferase genotype independently influence the arsenic methylation phenotype.
GeneRIF
Vahter et al., Stockholm, Sweden. In Pharmacogenet Genomics, 2012
Pregnancy and the DNMT1a genotype independently influence the arsenic methylation phenotype
Expression of DNA methyltransferases in the mouse uterus during early pregnancy and susceptibility to dietary folate deficiency.
GeneRIF
Wang et al., Chongqing, China. In Reproduction, 2012
results indicate that DNA methyltransferases 1, 3a and 3b may regulate the transcription of endometrial genes associated with embryo implantation and that levels of these are affected by dietary folate in mice
Mechanistic details of the DNA recognition by the Dnmt1 DNA methyltransferase.
GeneRIF
Jeltsch et al., Stuttgart, Germany. In Febs Lett, 2012
DNA recognition by the Dnmt1 DNA methyltransferase.
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