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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Ligase III, DNA, ATP-dependent

DNA ligase III, LIG3
This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: XRCC1, POLYMERASE, CAN, V1a, DNA repair enzyme
Papers using DNA ligase III antibodies
Yeast exonuclease 5 is essential for mitochondrial genome maintenance
Supplier
Yasukawa Takehiro et al., In Biochimica et Biophysica Acta, 2009
... DNA ligase III-specific dsRNA was designed using published information [25] and the synthesis was ordered through Qiagen.
Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts
Supplier
Winters Thomas A. et al., In Journal of Nucleic Acids, 2001
... Antibodies to DNA ligase III were from Novus Biologicals (Littleton, CO) ...
Papers on DNA ligase III
Ligase I and ligase III mediate the DNA double-strand break ligation in alternative end-joining.
New
Zhang et al., Beijing, China. In Proc Natl Acad Sci U S A, Feb 2016
By using a clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) system, we generated mouse CH12F3 cell lines in which, in addition to Lig4, either Lig1 or nuclear Lig3, representing the cells containing a single DNA ligase (Lig3 or Lig1, respectively) in their nucleus, was completely ablated.
Redundant function of DNA ligase 1 and 3 in alternative end-joining during immunoglobulin class switch recombination.
New
Yu et al., East Lansing, United States. In Proc Natl Acad Sci U S A, Feb 2016
Here, we report that CSR levels are not further reduced by deletion of either of the two remaining DNA ligases (Lig1 and nuclear Lig3) in Lig4(-/-) cells.
Microhomology-mediated end joining is the principal mediator of double-strand break repair during mitochondrial DNA lesions.
New
Raghavan et al., Bengaluru, India. In Mol Biol Cell, Feb 2016
Knockdown studies, in conjunction with other experiments, demonstrated that DNA ligase III, but not ligase IV or ligase I, is primarily responsible for the final sealing of DSBs during mitochondrial MMEJ.
Efficiency of Base Excision Repair of Oxidative DNA Damage and Its Impact on the Risk of Colorectal Cancer in the Polish Population.
New
Majsterek et al., Łódź, Poland. In Oxid Med Cell Longev, Dec 2015
In addition, polymorphisms of EXO1, LIG3, and PolB may modulate the risk of colorectal cancer by decreasing (PolB) or increasing (LIG3 and EXO1) the chance of malignant transformation.
Reprint of "Oxidant and environmental toxicant-induced effects compromise DNA ligation during base excision DNA repair".
Review
New
Wilson et al., United States. In Dna Repair (amst), Dec 2015
The conformational differences in DNA polymerase β (pol β) associated with incorrect or oxidized nucleotide (8-oxodGMP) insertion could impact channeling of the repair intermediate to the final step of BER, i.e., DNA ligation by DNA ligase I or the DNA Ligase III/XRCC1 complex.
Mitochondrial DNA damage induced autophagy, cell death, and disease.
New
Meyer et al., Durham, United States. In Front Biosci, Dec 2015
However, accumulation of certain types of mitochondrial damage, in the absence of DNA ligase III (Lig3) or exonuclease G (EXOG), can directly trigger cell death.
Oxidant and environmental toxicant-induced effects compromise DNA ligation during base excision DNA repair.
Review
New
Wilson et al., United States. In Dna Repair (amst), Nov 2015
The conformational differences in DNA polymerase β (pol β) associated with incorrect or oxidized nucleotide (8-oxodGMP) insertion could impact channeling of the repair intermediate to the final step of BER, i.e., DNA ligation by DNA ligase I or the DNA Ligase III/XRCC1 complex.
Alternative Okazaki Fragment Ligation Pathway by DNA Ligase III.
Review
Iliakis et al., Milano, Italy. In Genes (basel), 2014
Higher eukaryotes have three types of DNA ligases: DNA ligase 1 (Lig1), DNA ligase 3 (Lig3) and DNA ligase 4 (Lig4).
Structure and function of the DNA ligases encoded by the mammalian LIG3 gene.
Review
Sallmyr et al., Albuquerque, United States. In Gene, 2014
Among the mammalian genes encoding DNA ligases (LIG), the LIG3 gene is unique in that it encodes multiple DNA ligase polypeptides with different cellular functions.
DNA ligase III: a spotty presence in eukaryotes, but an essential function where tested.
Review
Jasin et al., New York City, United States. In Cell Cycle, 2011
Recently, DNA ligase III (Lig3) has been demonstrated to be crucial for cell survival due to its catalytic function in mitochondria.
Human Mre11/human Rad50/Nbs1 and DNA ligase IIIalpha/XRCC1 protein complexes act together in an alternative nonhomologous end joining pathway.
GeneRIF
Tomkinson et al., Baltimore, United States. In J Biol Chem, 2011
Human Mre11/human Rad50/Nbs1 and DNA ligase IIIalpha/XRCC1 protein complexes act together in an alternative nonhomologous end joining pathway.
Association between single nucleotide polymorphisms in the DNA repair gene LIG3 and acute adverse skin reactions following radiotherapy.
GeneRIF
Talbot et al., Leicester, United Kingdom. In Radiother Oncol, 2011
Using our cohort of 480 breast cancer patients, we provide replicated evidence that a polymorphism near the LIG3 gene is associated with acute skin toxicity following radiotherapy.
Crucial role for DNA ligase III in mitochondria but not in Xrcc1-dependent repair.
Impact
GeneRIF
Jasin et al., New York City, United States. In Nature, 2011
results establish a role for Lig3 in mitochondria, but distinguish it from its interacting protein Xrcc1
DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair.
Impact
McKinnon et al., Memphis, United States. In Nature, 2011
DNA replication and repair in mammalian cells involves three distinct DNA ligases: ligase I (Lig1), ligase III (Lig3) and ligase IV (Lig4).
Human DNA ligase III recognizes DNA ends by dynamic switching between two DNA-bound states.
GeneRIF
Ellenberger et al., Saint Louis, United States. In Biochemistry, 2010
The collective results support a "jackknife model" in which the ZnF loads ligase III onto nicked DNA and conformational changes deliver DNA into the active site.
TDP1 serine 81 promotes interaction with DNA ligase IIIalpha and facilitates cell survival following DNA damage.
GeneRIF
El-Khamisy et al., Brighton, United Kingdom. In Cell Cycle, 2010
The interaction with Lig3alpha is promoted by serine 81 that is located within a putative S/TQ site in the N-terminus domain of TDP1.
Common variants at ten loci influence QT interval duration in the QTGEN Study.
Impact
Stricker et al., Boston, United States. In Nat Genet, 2009
Associations were found at five newly identified loci, including 16q21 near NDRG4 and GINS3, 6q22 near PLN, 1p36 near RNF207, 16p13 near LITAF and 17q12 near LIG3 and RFFL.
Eukaryotic DNA ligases: structural and functional insights.
Review
Impact
Tomkinson et al., Saint Louis, United States. In Annu Rev Biochem, 2007
Members of the DNA ligase I and IV families are found in all eukaryotes, whereas DNA ligase III family members are restricted to vertebrates.
The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates.
Impact
West et al., London, United Kingdom. In Nature, 2006
Aprataxin associates with the DNA repair proteins XRCC1 and XRCC4, which are partners of DNA ligase III and ligase IV, respectively, suggestive of a role in DNA repair.
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