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DNA helicase B
This gene encodes a DNA-dependent ATPase which catalyzes the unwinding of DNA necessary for DNA replication, repair, recombination, and transcription. This gene is thought to function specifically during the S phase entry of the cell cycle. [provided by RefSeq, Mar 2012] (from NCBI)
Top mentioned proteins: ATPase, POLYMERASE, RPA, adenosinetriphosphatase, PCNA
Papers on DNA helicase B
HELB Is a Feedback Inhibitor of DNA End Resection.
Durocher et al., Toronto, Canada. In Mol Cell, Feb 2016
Here we report that DNA helicase B (HELB) underpins a feedback inhibition mechanism that curtails resection.
Human DNA helicase B interacts with the replication initiation protein Cdc45 and facilitates Cdc45 binding onto chromatin.
Fanning et al., United States. In Exp Cell Res, Jul 2015
We found that depletion of the human DNA helicase B (HDHB) inhibits the initiation of DNA replication, suggesting a role of HDHB in the beginning of the DNA synthesis.
Human DNA helicase B functions in cellular homologous recombination and stimulates Rad51-mediated 5'-3' heteroduplex extension in vitro.
Fanning et al., Nashville, United States. In Plos One, 2014
Human DNA helicase B (HDHB) is a robust 5'-3' DNA helicase which accumulates on chromatin in cells exposed to DNA damage.
Human DNA helicase B (HDHB) binds to replication protein A and facilitates cellular recovery from replication stress.
Fanning et al., Nashville, United States. In J Biol Chem, 2012
Replication stress-induced recruitment of HDHB to chromatin is independent of checkpoint signaling but correlates with the level of replication protein A (RPA) recruited to chromatin.
Interaction of heliquinomycin with single-stranded DNA inhibits MCM4/6/7 helicase.
Ishimi et al., Mito, Japan. In J Biochem, 2012
Among the DNA helicases involved in DNA replication, DNA helicase B was inhibited by heliquinomycin at IC(50) of 4.3 µM and RECQL4 helicase at IC(50) of 14 µM; these values are higher than that of MCM4/6/7 helicase (2.5 µM).
Differential gene expression profile from haematopoietic tissue stem cells of red claw crayfish, Cherax quadricarinatus, in response to WSSV infection.
Wang et al., Xiamen, China. In Dev Comp Immunol, 2011
To further confirm the up-regulation of differentially expressed genes, the semi-quantitative RT-PCR were performed to test twenty randomly selected genes, in which eight of the selected genes exhibited clear up-regulation upon WSSV infection in red claw crayfish Hpt cells, including DNA helicase B-like, multiprotein bridging factor 1, apoptosis-linked gene 2 and an unknown gene-L1635 from L1 library; coatomer gamma subunit, gabarap protein gene, tripartite motif-containing 32 and an unknown gene-L12-254 from L2 library, respectively.
Cell cycle-dependent regulation of a human DNA helicase that localizes in DNA damage foci.
Fanning et al., Nashville, United States. In Mol Biol Cell, 2004
Mutational studies of human DNA helicase B (HDHB) have suggested that its activity is critical for the G1/S transition of the cell cycle, but the nature of its role remains unknown.
A dominant-negative mutant of human DNA helicase B blocks the onset of chromosomal DNA replication.
Fanning et al., Nashville, United States. In J Biol Chem, 2002
role of dominant-negative mutant in blocking onset of chromosomal DNA replication
Stimulation of DNA synthesis by mouse DNA helicase B in a DNA replication system containing eukaryotic replication origins.
Ishimi et al., Tokyo, Japan. In Biochemistry, 1995
We report here that DNA helicase B isolated from mouse FM3A cells can greatly stimulate DNA synthesis in this replication system in place of SV40 T antigen.
Stimulation of mouse DNA primase-catalyzed oligoribonucleotide synthesis by mouse DNA helicase B.
Enomoto et al., Tokyo, Japan. In Nucleic Acids Res, 1995
To assess the stimulation of DNA primase activity by mammalian DNA helicases, we analyzed the synthesis of oligoribonucleotides by mouse DNA polymerase alpha-primase complex on single-stranded circular M13 DNA in the presence of mouse DNA helicase B. DNA helicase B was purified by sequential chromatography through eight columns.
Biochemical and genetic characterization of a replication protein A dependent DNA helicase from the yeast, Saccharomyces cerevisiae.
Biswas et al., Baltimore, United States. In Biochem Biophys Res Commun, 1995
We have purified a DNA dependent ATPase/DNA helicase, DNA helicase B, from S. cerevisiae.
Characterization of DNA synthesis and DNA-dependent ATPase activity at a restrictive temperature in temperature-sensitive tsFT848 cells with thermolabile DNA helicase B.
Enomoto et al., Tokyo, Japan. In Mol Cell Biol, 1995
In mutant cells, the DNA-dependent ATPase activity of DNA helicase B, which is a major DNA-dependent ATPase in wild-type cells, decreased at the nonpermissive temperature of 39 degrees C. DNA synthesis in tsFT848 cells at the nonpermissive temperature was analyzed in detail.
Three new DNA helicases from Saccharomyces cerevisiae.
Burgers et al., Saint Louis, United States. In Chromosoma, 1991
On the other hand, DNA helicase D used dTTP, but not GTP, and DNA helicase B used neither nucleotide as cofactor.
Further characterization of DNA helicase activity of mouse DNA-dependent adenosinetriphosphatase B (DNA helicase B).
Ui et al., Tokyo, Japan. In Biochemistry, 1988
The helicase B was found to migrate along single-stranded DNA in the 5' to 3' direction by the use of single strands with short duplex regions at both 3' and 5' ends as substrate.
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