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Dystrophia myotonica, WD repeat containing

DMWD, DMR-N9, dystrophia myotonica-containing WD repeat motif
Top mentioned proteins: DM2, SIX5, POLYMERASE, BOULE, ACID
Papers on DMWD
Epigenetics of the myotonic dystrophy-associated DMPK gene neighborhood.
New
Ehrlich et al., New Orleans, United States. In Epigenomics, Jan 2016
MATERIALS & METHODS: At DMPK and its flanking genes (DMWD, SIX5, BHMG1 and RSPH6A), we analyzed many epigenetic and transcription profiles from myoblasts, myotubes, skeletal muscle, heart and 30 nonmuscle samples.
Real-time RT-PCR for CTG repeat-containing genes.
Eriksson, Huddinge, Sweden. In Methods Mol Biol, 2003
SIX5 is a homeodomain gene located just downstream of the repeat, and myotonic dystrophy WD protein (DMWD) is located close upstream of DMPK.
Searching for candidate genes for male infertility.
Baker et al., Melbourne, Australia. In Asian J Androl, 2003
METHODS AND RESULTS: To demonstrate this in silico research, the following male infertility candidate genes were selected: (1) human BOULE, mutations of which may lead to germ cell arrest at the primary spermatocyte stage, (2) mutations of casein kinase 2 alpha genes which may cause globozoospermia, (3) DMR-N9 which is possibly involved in the spermatogenic defect of myotonic dystrophy and (4) several testes expressed genes at or near the breakpoints of a balanced translocation associated with hypospermatogenesis.
The DMWD protein from the myotonic dystrophy (DM1) gene region is developmentally regulated and is present most prominently in synapse-dense brain areas.
GeneRIF
Wieringa et al., Nijmegen, Netherlands. In Brain Res, 2003
The DMWD protein level gradually increased, was expressed specifically in the neuropil of areas with a high density of synaptic connections and was dispersed in a punctuate fashion throughout the neural cell body, but excluded from axons
Decreased DMPK transcript levels in myotonic dystrophy 1 type IIA muscle fibers.
Ansved et al., Stockholm, Sweden. In Biochem Biophys Res Commun, 2001
The repeat lies in the 3' untranslated region of the myotonic dystrophy protein kinase gene (DMPK), and it has been hypothesised that the expansion alters the expression levels of DMPK and/or its neighbouring genes, DMWD and SIX5.
Effect of triplet repeat expansion on chromatin structure and expression of DMPK and neighboring genes, SIX5 and DMWD, in myotonic dystrophy.
Funanage et al., Wilmington, United States. In Mol Genet Metab, 2001
This change in chromatin structure has been proposed as a mechanism whereby the expression of DMPK and neighboring genes, sine oculis homeobox (Drosophila) homolog 5 (SIX5) and dystrophia myotonica-containing WD repeat motif (DMWD), might be affected.
Independent regulation of the myotonic dystrophy 1 locus genes postnatally and during adult skeletal muscle regeneration.
Carey et al., Stockholm, Sweden. In J Biol Chem, 2000
Myotonic dystrophy is caused by a CTG(n) expansion in the 3'-untranslated region of a serine/threonine protein kinase gene (DMPK), which is flanked by two other genes, DMWD and SIX5.
The Aspergillus nidulans creC gene involved in carbon catabolite repression encodes a WD40 repeat protein.
Kelly et al., Adelaide, Australia. In Mol Gen Genet, 2000
The CreC protein is highly conserved relative to the Schizosaccharomyces pombe protein Yde3--whose function is unknown--and human and mouse DMR-N9, which may be associated with myotonic dystrophy.
Myotonic dystrophy is associated with a reduced level of RNA from the DMWD allele adjacent to the expanded repeat.
Brook et al., Nottingham, United Kingdom. In Hum Mol Genet, 1999
We have examined the effect of repeat expansion on the level of RNA from a third gene, DMWD.
Expanding complexity in myotonic dystrophy.
Review
Wieringa et al., Nijmegen, Netherlands. In Bioessays, 1998
There is now circumstantial evidence that long (CTG)n repeats may affect the expression of any of at least three genes, myotonic dystrophy protein kinase (DMPK), DMR-N9 (gene 59), and a DM-associated homeodomain protein (DMAHP).
Structural organization and developmental expression pattern of the mouse WD-repeat gene DMR-N9 immediately upstream of the myotonic dystrophy locus.
Wieringa et al., Nijmegen, Netherlands. In Hum Mol Genet, 1995
Here we report on the elucidation of the complete genomic structure and expression pattern of the mouse DMR-N9 gene (called 59 gene in humans), which is at 1.1 kbp upstream of the DM-PK gene.
Genomic organization and transcriptional units at the myotonic dystrophy locus.
Harper et al., Cardiff, United Kingdom. In Genomics, 1993
Located in close proximity is a second gene, coding for a transcript of about 3 kb, that is homologous to the gene DMR-N9 in the corresponding mouse locus, but has no homologies to other known genes or proteins.
Characterization of the myotonic dystrophy region predicts multiple protein isoform-encoding mRNAs.
Impact
Lennon et al., Nijmegen, Netherlands. In Nat Genet, 1992
Characterization of the DM region of both species reveals another active gene (DMR-N9) in close proximity to the kinase gene.
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