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Solute carrier family 11

DMT1, divalent metal transporter 1, Nramp2, DCT1
This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010] (from NCBI)
Top mentioned proteins: Transferrin, CAN, Hepcidin, V1a, HAD
Papers using DMT1 antibodies
Dynamic traffic through the recycling compartment couples the metal transporter Nramp2 (DMT1) with the transferrin receptor
Supplier
Clapham David E et al., In PLoS Biology, 2002
... DMT1 gene was subcloned into pRevTRE (Clontech, Palo Alto, California, United ...
Papers on DMT1
Hyperglycemia Does Not Affect Iron Mediated Toxicity of Cultured Endothelial and Renal Tubular Epithelial Cells: Influence of L-Carnosine.
New
Hauske et al., Mannheim, Germany. In J Diabetes Res, Dec 2015
HG did not change the expression of divalent metal transporter 1 (DMT1), ferroportin (IREG), and transferrin receptor protein 1 (TFRC).
Mechanisms of divalent metal toxicity in affective disorders.
Review
New
Kim et al., Boston, United States. In Toxicology, Dec 2015
The divalent metal transporter 1 (DMT1) is a major metal transporter involved in the absorption and metabolism of several essential metals like iron and manganese.
Manganese homeostasis in the nervous system.
Review
New
Aschner et al., New York City, United States. In J Neurochem, Aug 2015
Manganese homeostasis is tightly regulated by transporters, including transmembrane importers (divalent metal transporter 1, transferrin and its receptor, zinc transporters ZIP8 and Zip14, dopamine transporter, calcium channels, choline transporters and citrate transporters) and exporters (ferroportin and SLC30A10), as well as the intracellular trafficking proteins (SPCA1 and ATP12A2).
Iron and Iron-Related Proteins in Asbestosis.
Roggli et al., Durham, United States. In J Environ Pathol Toxicol Oncol, 2014
Lung tissue from six individuals diagnosed to have had asbestosis at autopsy was stained for iron, ferritin, divalent metal transporter 1 (DMT1), and ferroportin 1 (FPN1).
Biochemical changes correlated with blood thiamine and its phosphate esters levels in patients with diabetes type 1 (DMT1).
Alokail et al., Riyadh, Saudi Arabia. In Int J Clin Exp Pathol, 2014
However, little is known on the positive effects of thiamine in diabetic type 1 (DMT1) patients.
Divalent metal transporter 1 (DMT1) in the brain: implications for a role in iron transport at the blood-brain barrier, and neuronal and glial pathology.
Review
Moos et al., Aalborg, Denmark. In Front Mol Neurosci, 2014
In this review, we focus on iron transport in the brain and the role of the divalent metal transporter 1 (DMT1) vital for iron uptake in most cells.
Iron entry in neurons and astrocytes: a link with synaptic activity.
Review
Grohovaz et al., Milano, Italy. In Front Mol Neurosci, 2014
Different calcium permeable channels as well as the divalent metal transporter 1 (DMT1) have been proposed to sustain NTBI entry in neurons and astrocytes even though it remains an open issue.
Cardiomyopathy associated with iron overload: how does iron enter myocytes and what are the implications for pharmacological therapy?
Review
Chattipakorn et al., Chiang Mai, Thailand. In Hemoglobin, 2014
These include both L-type (LTCC) and T-type (TTCC) calcium channels, divalent metal transporter 1 (DMT1) and transferrin receptors (TfRs).
Effects of Pregnancy and Lactation on Iron Metabolism in Rats.
Chang et al., Shijiazhuang, China. In Biomed Res Int, 2014
Rats with different days of gestation and lactation were used to determine the variations in iron stores and serum iron level and the changes in expression of iron metabolism-related proteins, including ferritin, ferroportin 1 (FPN1), ceruloplasmin (Cp), divalent metal transporter 1 (DMT1), transferrin receptor 1 (TfR1), and the major iron-regulatory molecule-hepcidin.
EGCG Protects against 6-OHDA-Induced Neurotoxicity in a Cell Culture Model.
Reddy et al., Ames, United States. In Parkinsons Dis, 2014
6-OHDA treatment significantly (p < 0.05) increased divalent metal transporter-1 (DMT1) and hepcidin and decreased ferroportin 1 (Fpn1) level, whereas pretreatment with EGCG counteracted the effects.
Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic β cell fate in response to cytokines.
Impact
Mandrup-Poulsen et al., Copenhagen, Denmark. In Cell Metab, 2012
Through a combination of in vitro and in vivo studies, we show that the proinflammatory cytokine IL-1β induces divalent metal transporter 1 (DMT1) expression correlating with increased β cell iron content and ROS production.
Substrate profile and metal-ion selectivity of human divalent metal-ion transporter-1.
GeneRIF
Mackenzie et al., Cincinnati, United States. In J Biol Chem, 2012
Substrate profile and metal-ion selectivity of human divalent metal-ion transporter-1.
Roles of ZIP8, ZIP14, and DMT1 in transport of cadmium and manganese in mouse kidney proximal tubule cells.
GeneRIF
Himeno et al., Tokushima, Japan. In Metallomics, 2012
The knockdown of ZIP8, ZIP14 or DMT1 by siRNA transfection significantly reduced the uptake of Cd(2+) and Mn(2+) from the apical membrane.
Relative contribution of CTR1 and DMT1 in copper transport by the blood-CSF barrier: implication in manganese-induced neurotoxicity.
GeneRIF
Zheng et al., West Lafayette, United States. In Toxicol Appl Pharmacol, 2012
These data indicate that CTR1, but not DMT1, plays an essential role in transporting Cu by the blood-CSF barrier in the choroid plexus
Candidate gene sequencing of SLC11A2 and TMPRSS6 in a family with severe anaemia: common SNPs, rare haplotypes, no causative mutation.
GeneRIF
Weiss et al., Innsbruck, Austria. In Plos One, 2011
sequenced exons and exon-intron boundaries of SLC11A2 and TMPRSS6 in all 6 family members with iron-refractory iron deficiency anaemia; cannot exclude or confirm a gene-gene interaction between SLC11A2 and TMPRSS6; gene sequencing did not reveal causative rare mutations
1B/(-)IRE DMT1 expression during brain ischemia contributes to cell death mediated by NF-κB/RelA acetylation at Lys310.
GeneRIF
Pizzi et al., Brescia, Italy. In Plos One, 2011
that 1B/(-)IRE DMT1 expression and intracellular iron influx are early downstream responses to NF-kappaB/RelA activation and acetylation during brain ischemia and contribute to the pathogenesis of stroke-induced neuronal damage
The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels.
Impact
Rouault et al., Bethesda, United States. In Cancer Cell, 2011
Reduced AMPK levels lead to diminished expression of the DMT1 iron transporter, and the resulting cytosolic iron deficiency activates the iron regulatory proteins, IRP1 and IRP2, and increases expression of the hypoxia inducible factor HIF-1α, but not HIF-2α.
Intestinal ferritin H is required for an accurate control of iron absorption.
Impact
Kühn et al., Lausanne, Switzerland. In Cell Metab, 2010
As expected for iron-loaded animals, the ferritin H-deleted mice showed induced liver hepcidin mRNA levels and reduced duodenal expression of DMT1 and DcytB mRNA.
Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency.
Impact
Gonzalez et al., Bethesda, United States. In Cell Metab, 2009
Duodenal cytochrome b (DcytB) and divalent metal transporter 1 (DMT1) are regulators of iron absorption.
The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel.
Impact
Xu et al., Ann Arbor, United States. In Nature, 2008
The divalent metal transporter protein DMT1 (also known as SLC11A2) is the only endosomal Fe(2+) transporter known at present and it is highly expressed in erythroid precursors.
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