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Doublesex and mab-3 related transcription factor 1

DMRT1
This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, FOXL2, HAD, SRY, AMH
Papers on DMRT1
Identification of the molecular sex-differentiation period in the siberian sturgeon.
New
Quagio-Grassiotto et al., Montevideo, Uruguay. In Mol Reprod Dev, Jan 2016
The genes amh, sox9, and dmrt1 were selected as male gonad markers; cyp19a1a and foxl2a as female gonad markers; and cyp17a1 and ar as markers of steroid synthesis and steroid receptivity.
Molecular characterization and expression pattern of dmrt1 in the immature Chinese sturgeon Acipenser sinensis.
New
Cao et al., Wuhan, China. In J Fish Biol, Jan 2016
UNASSIGNED: In this study, the cDNA of dmrt1 gene from the Chinese sturgeon Acipenser sinensis was isolated and its expression pattern was characterized in different tissues of immature A. sinensis.
Submicroscopic copy-number variations associated with 46,XY disorders of sex development.
New
Fukami et al., Tokyo, Japan. In Mol Cell Pediatr, Dec 2015
These CNVs included deletions involving known causative genes such as DMRT1 or NR5A1, duplications involving NR0B1, deletions involving putative cis-regulatory elements of SOX9, and various deletions and duplications of unknown pathogenicity.
Coordinated microRNA and messenger RNA expression profiles for understanding sexual dimorphism of gonads and the potential roles of microRNA in the steroidogenesis pathway in Nile tilapia (Oreochromis niloticus).
New
Song et al., China. In Theriogenology, Dec 2015
Seven functional miRNA-target gene pairs, miR-17-5p/DMRT1, miR-20a/DMRT1, miR-138/CYP17A2, miR-338/CYP17A2, miR-200a/CYP17A2, miR-456/AMH, and miR-138/AMH, were predicted at the sequence level and further detected by real-time polymerase chain reaction on the basis of the significantly negative relationships.
Etiology and early pathogenesis of malignant testicular germ cell tumors: towards possibilities for preinvasive diagnosis.
Review
New
Looijenga et al., Rotterdam, Netherlands. In Asian J Androl, May 2015
Since 2009, several genome wide association studies (GWAS) have been published, reporting on single-nucleotide polymorphisms (SNPs) with significant associations in or near the genes KITLG, SPRY4, BAK1, DMRT1, TERT, ATF7IP, HPGDS, MAD1L1, RFWD3, TEX14, and PPM1E, likely to be related to TGCT development.
Intratubular germ cell neoplasia of the testis: a brief review.
Review
New
Akhtar et al., Riyadh, Saudi Arabia. In Adv Anat Pathol, May 2015
The cell of origin of this tumor is probably postpubertal mature spermatogonia which acquire abnormal proliferative capability probably due to gain of chromosome 9 resulting in activation and amplification of genes such as DMRT1.
Complex evolutionary trajectories of sex chromosomes across bird taxa.
Impact
Zhang et al., Berkeley, United States. In Science, 2015
Punctuated events of shared or lineage-specific recombination suppression have produced a gradient of "evolutionary strata" along the Z chromosome, which initiates from the putative avian sex-determining gene DMRT1 and ends at the pseudoautosomal region.
Sexual Fate Reprogramming in the Steroid-Induced Bi-Directional Sex Change in the Protogynous Orange-Spotted Grouper, Epinephelus coioides.
Chang et al., Chi-lung, Taiwan. In Plos One, 2014
These male characteristics included increased plasma 11-ketotestosterone (11-KT), decreased estradiol (E2) levels, increased male-related gene (dmrt1, sox9, and cyp11b2) expression, and decreased female-related gene (figla, foxl2, and cyp19a1a) expression.
Transcriptional control of spermatogonial maintenance and differentiation.
Review
Wilkinson et al., San Diego, United States. In Semin Cell Dev Biol, 2014
Several transcription factors have been identified that promote spermatogonial differentiation (DMRT1, NGN3, SOHLH1, SOHLH2, SOX3, and STAT3); some of these may influence the decision of an SSC to commit to differentiate while others may promote later spermatogonial differentiation steps.
Avian sex, sex chromosomes, and dosage compensation in the age of genomics.
Review
Graves, Melbourne, Australia. In Chromosome Res, 2014
Different sex-determining genes, DMRT1 and SRY, define the ZW and XY systems, but DMRT1 is involved in downstream events in mammals.
Whole-genome sequence of a flatfish provides insights into ZW sex chromosome evolution and adaptation to a benthic lifestyle.
Impact
Wang et al., Qingdao, China. In Nat Genet, 2014
Notably, the same gene on the Z chromosome, dmrt1, which is the male-determining gene in birds, showed convergent evolution of features that are compatible with a similar function in tongue sole.
Genetic changes in nonepithelial ovarian cancer.
Review
Vergote et al., Leuven, Belgium. In Expert Rev Anticancer Ther, 2013
In the latter, recent genome-wide association studies have identified seven susceptibility loci near KITLG, SPRY4, UKC2, BAK1, DMRT1, TERT and ATF7IP.
DMRT1 prevents female reprogramming in the postnatal mammalian testis.
Impact
GeneRIF
Zarkower et al., Minneapolis, United States. In Nature, 2011
sexual fate is surprisingly labile in the testis: loss of the DMRT1 transcription factor in mouse Sertoli cells, even in adults, activates Foxl2 and reprograms Sertoli cells into granulosa cells
A second independent locus within DMRT1 is associated with testicular germ cell tumor susceptibility.
GeneRIF
Nathanson et al., Philadelphia, United States. In Hum Mol Genet, 2011
Findings continue to corroborate that genes influencing male germ cell development and differentiation have emerged as the major players in inherited TGCT susceptibility.
DMRT1 promotes oogenesis by transcriptional activation of Stra8 in the mammalian fetal ovary.
GeneRIF
Zarkower et al., Minneapolis, United States. In Dev Biol, 2011
DMRT1 controls Stra8 sex-specifically, activating it in the fetal ovary and repressing it in the adult testis.
Variants in or near KITLG, BAK1, DMRT1, and TERT-CLPTM1L predispose to familial testicular germ cell tumour.
GeneRIF
Greene et al., Rockville, United States. In J Med Genet, 2011
variants in or near BAK1, DMRT1, TERT-CLPTM1L, and KITLG predispose to familial and bilateral TGCT.
Intestinal iron absorption: regulation by dietary & systemic factors.
GeneRIF
Sharp, London, United Kingdom. In Int J Vitam Nutr Res, 2010
There is evidence that DMT1 expression and function respond rapidly to changes in dietary iron content
Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer.
Impact
GeneRIF
UK Testicular Cancer Collaboration et al., United Kingdom. In Nat Genet, 2010
Studies identified three new susceptibility loci DMRT1, TERT and ATF7IP associated with testicular germ cell cancer.
The avian Z-linked gene DMRT1 is required for male sex determination in the chicken.
Impact
Sinclair et al., Melbourne, Australia. In Nature, 2009
A strong candidate avian sex-determinant under the dosage hypothesis is the conserved Z-linked gene, DMRT1 (doublesex and mab-3-related transcription factor 1).
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