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Dentin matrix protein 1

DMP1, dentin matrix protein 1, AgI, Ag-1
acidic protein associated with the dentin matrix; may be a matrix-associated acidic phosphoprotein; may have a regulatory role in dentin mineralization [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, DSP, osteopontin, ACID, HAD
Papers using DMP1 antibodies
Osteocyte Wnt/beta-catenin signaling is required for normal bone homeostasis
Supplier
Bellido Teresita et al., In Journal of Bone and Mineral Research, 2009
... Generation of DMP1-caPTHR1 transgenic mice has been described ...
The NH2-terminal and COOH-terminal fragments of dentin matrix protein 1 (DMP-1) localize differently in the compartments of dentin and growth plate of bone
Supplier
Feng Jian Q et al., In Journal of Bone and Mineral Research, 2008
... Dmp1 knockout (KO) mice with a C57B/L6 genetic background have been described previously.(21)
Localization of two homologous Arabidopsis kinesin-related proteins in the phragmoplast
Supplier
Meier Iris et al., In BMC Evolutionary Biology, 2003
... AGI locus numbers from TAIR are used as sequence IDs for Arabidopsis, TIGR sequence ...
Papers on DMP1
Effect of biphasic calcium phosphate scaffold porosities on odontogenic differentiation of human dental pulp cells.
New
Mahmood et al., Baghdad, Iraq. In J Biomater Appl, Feb 2016
However, the cells cultured with BCP3 extract revealed high alkaline phosphatase (ALP) activity and high expression of odontoblast related genes, collagen type I alpha 1, dentin matrix protein-1, and dentin sialophosphoprotein as compared to that cultured with BCP1, BCP2, and BCP4 extracts.
CONSENSUS STATEMENT BY THE AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY ON THE COMPREHENSIVE TYPE 2 DIABETES MANAGEMENT ALGORITHM - 2016 EXECUTIVE SUMMARY.
New
Umpierrez et al., In Endocr Pract, Jan 2016
ABBREVIATIONS: A1C = hemoglobin A1C AACE = American Association of Clinical Endocrinologists ACCORD = Action to Control Cardiovascular Risk in Diabetes ACCORD BP = Action to Control Cardiovascular Risk in Diabetes Blood Pressure ACEI = angiotensinconverting enzyme inhibitor AGI = alpha-glucosidase inhibitor apo B = apolipoprotein B ARB = angiotensin II receptor blocker ASCVD = atherosclerotic cardiovascular disease BAS = bile acid sequestrant BMI = body mass index BP = blood pressure CHD = coronary heart disease CKD = chronic kidney disease CVD = cardiovascular disease DKA = diabetic ketoacidosis DPP-4 = dipeptidyl peptidase 4 EPA = eicosapentaenoic acid FDA = Food and Drug Administration GLP-1 = glucagon-like peptide 1 HDL-C = high-density-lipoprotein cholesterol LDL-C = low-densitylipoprotein cholesterol LDL-P = low-density-lipoprotein particle Look AHEAD = Look Action for Health in Diabetes NPH = neutral protamine Hagedorn OSA = obstructive sleep apnea SFU = sulfonylurea SGLT-2 = sodium glucose cotransporter-2 SMBG = self-monitoring of blood glucose T2D = type 2 diabetes TZD = thiazolidinedione.
A nanocomposite of Au-AgI core/shell dimer as a dual-modality contrast agent for x-ray computed tomography and photoacoustic imaging.
New
Mao et al., Atlanta, United States. In Med Phys, Jan 2016
RESULTS: The characterizations of prepared Au/AgI core/shell nanostructure confirmed the formation of Au/AgICSD nanodimers.
Sclerostin antibody (Scl-Ab) improves osteomalacia phenotype in dentin matrix protein 1(Dmp1) knockout mice with little impact on serum levels of phosphorus and FGF23.
New
Feng et al., Dallas, United States. In Matrix Biol, Jan 2016
Here, we used Dmp1 knockout (KO) mice (whose mutations led to the same type of autosomal recessive hypophosphatemic rickets in humans) as the model in which the monoclonal antibody of sclerostin (Scl-Ab) was tested in two age groups for 8weeks: the prevention group (starting at age 4weeks) and the treatment group (starting at age 12weeks).
Full-length amelogenin influences the differentiation of human dental pulp stem cells.
New
Folwaczny et al., München, Germany. In Stem Cell Res Ther, Dec 2015
The groups were compared to the unstimulated control in terms of cell morphology and proliferation, mineralization and gene expression for ALP (alkaline phosphatase), DMP1 (dentin matrix protein-1) and DSPP (dentin sialophosphoprotein). RESULTS: Amelogenin affects hDPSCs differently than PDL (periodontal ligament) cells and other cell lines.
Phosphate homeostasis and genetic mutations of familial hypophosphatemic rickets.
Review
New
Thilakavathy et al., In J Pediatr Endocrinol Metab, Sep 2015
X-linked hypophosphatemia (XLH), autosomal dominant HR (ADHR), and autosomal recessive HR (ARHR) are examples of hereditary forms of HR, which are mainly caused by mutations in the phosphate regulating endopeptidase homolog, X-linked (PHEX), FGF23, and, dentin matrix protein-1 (DMP1) and ecto-nucleotide pyro phosphatase/phosphodiesterase 1 (ENPP1) genes, respectively.
A unified model for bone-renal mineral and energy metabolism.
Review
New
Rowe, Kansas City, United States. In Curr Opin Pharmacol, Jun 2015
These proteins include dentin matrix protein 1 (DMP1), osteopontin, dentin-sialophosphoprotein (DSPP), statherin, bone sialoprotein (BSP) and MEPE.
Natural history and therapy of TTR-cardiac amyloidosis: emerging disease-modifying therapies from organ transplantation to stabilizer and silencer drugs.
Review
New
Maurer et al., New York City, United States. In Heart Fail Rev, Mar 2015
From organ transplantation to transthyretin stabilizers (diflunisal, tafamidis, AG-1), TTR silencers (ALN-ATTR02, ISIS-TTR(Rx)), and degraders of amyloid fibrils (doxycycline/TUDCA), the potential for effective transthyretin amyloid therapy is greater now than ever before.
Molecular and genetic aspects of controlling the soilborne necrotrophic pathogens Rhizoctonia and Pythium.
Review
Blechl et al., Pullman, United States. In Plant Sci, 2014
This review discusses the recent deployment of introduced genes and genome-based information for control of Rhizoctonia, with emphasis on three pathosystems: Rhizoctonia solani AG8 and wheat, R. solani AG1-IA and rice, and R. solani AG3 or AG4 and potato.
SIBLINGs and SPARC families: their emerging roles in pancreatic cancer.
Review
Berger et al., Heidelberg, Germany. In World J Gastroenterol, 2014
SIBLINGs consist of five members, which include osteopontin (OPN), bone sialoprotein, dentin matrix protein 1, dentin sialophosphoprotein and matrix extracellular phosphoglycoprotein.
The rachitic tooth.
Review
Impact
Somerman et al., Bethesda, United States. In Endocr Rev, 2014
Here we discuss conditions fitting under the umbrella of rickets, which traditionally referred to skeletal disease associated with vitamin D deficiency but has been more recently expanded to include newly identified factors involved in endocrine regulation of vitamin D, phosphate, and calcium, including phosphate-regulating endopeptidase homolog, X-linked, fibroblast growth factor 23, and dentin matrix protein 1. Systemic mineral metabolism intersects with local regulation of mineralization, and factors including tissue nonspecific alkaline phosphatase are necessary for proper mineralization, where rickets can result from loss of activity of tissue nonspecific alkaline phosphatase.
An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.
Impact
Mellinghoff et al., New York City, United States. In Science, 2013
A selective R132H-IDH1 inhibitor (AGI-5198) identified through a high-throughput screen blocked, in a dose-dependent manner, the ability of the mutant enzyme (mIDH1) to produce R-2-hydroxyglutarate (R-2HG).
Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation.
Impact
Yen et al., Cambridge, United States. In Science, 2013
We developed a small molecule, AGI-6780, that potently and selectively inhibits the tumor-associated mutant IDH2/R140Q.
Nuclear localization of DMP1 proteins suggests a role in intracellular signaling.
GeneRIF
Lu et al., Dallas, United States. In Biochem Biophys Res Commun, 2012
these findings suggest that, apart from its role as a constituent of dentin and bone matrix, DMP1 might play a regulatory role in the nucleus.
DMP1 is a target of let-7 in dental pulp cells.
GeneRIF
Fang et al., Guangzhou, China. In Int J Mol Med, 2012
DMP1 is regulated post-transcriptionally by let-7 during odontoblast differentiation.
Dmp1 physically interacts with p53 and positively regulates p53's stability, nuclear localization, and function.
GeneRIF
Inoue et al., Winston-Salem, United States. In Cancer Res, 2012
new mechanism of p53 activation mediated by direct physical interaction between Dmp1 and p53.
Dentin matrix protein-1 activates dental pulp fibroblasts.
GeneRIF
Vliagoftis et al., Edmonton, Canada. In J Endod, 2012
DMP-1 stimulated production of IL-6/IL-8 from pulp fibroblasts. Inhibition of p38 mitogen-activated protein kinase pathway blocked proinflammatory effect on pulp fibroblasts. DMP-1 might participate in development of inflammatory changes in pulp.
[Effects of simvastatin plus all-trans retinoic acid on WT1/hDMP1 gene expression profiles of human promyelocytic leukemia cell line NB4].
GeneRIF
Cao et al., Changzhou, China. In Zhonghua Yi Xue Za Zhi, 2011
Simvastatin plus all-trans retinoic acid reduces expression of WT1 and DMP1 in the promyelocytic leukemia cell line NB4.
Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): multifunctional proteins in cancer.
Review
Impact
Fedarko et al., Liège, Belgium. In Nat Rev Cancer, 2008
The family of glycophosphoproteins comprising osteopontin, bone sialoprotein, dentin matrix protein 1, dentin sialophosphoprotein and matrix extracellular phosphoglycoprotein - small integrin-binding ligand N-linked glycoproteins (SIBLINGs) - are emerging as important players in many stages of cancer progression.
Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer.
Impact
GeneRIF
Inoue et al., Winston-Salem, United States. In Cancer Cell, 2007
Loss of heterozygosity (LOH) of the hDMP1 gene was detectable in approximately 35% of human lung carcinomas, which was found in mutually exclusive fashion with LOH of INK4a/ARF or that of P53. DMP1 is a pivotal tumor suppressor for human lung cancers.
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