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DMC1 Dmc1p

Dmc1
The protein encoded by this gene is essential for meiotic homologous recombination. Genetic recombination in meiosis plays an important role in generating diversity of genetic information. The product of this gene is structurally and evolutionary related to the products of the yeast RAD51 and E. coli RecA genes. Alternative splice variants of this gene have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Rad51, CAN, Spo11, ACID, SCP3
Papers on Dmc1
Recombination between the mouse Y chromosome short arm and an additional Y short arm-derived chromosomal segment attached distal to the X chromosome PAR.
Review
New
Burgoyne et al., Marseille, France. In Chromosoma, Dec 2015
UNASSIGNED: In a male mouse, meiosis markers of processed DNA double strand breaks (DSBs) such as DMC1 and RAD51 are regularly seen in the non-PAR region of the X chromosome; these disappear late in prophase prior to entry into the first meiotic metaphase.
A surge of late-occurring meiotic double-strand breaks rescues synapsis abnormalities in spermatocytes of mice with hypomorphic expression of SPO11.
New
Barchi et al., Roma, Italy. In Chromosoma, Nov 2015
Conversely, DMC1 foci number is increased at pachynema, suggesting that under these experimental conditions, DSBs are likely made with delayed kinetics at zygonema.
Functional Relationship of ATP Hydrolysis, Presynaptic Filament Stability, and Homologous DNA Pairing Activity of the Human Meiotic Recombinase DMC1.
New
Chi et al., Taipei, Taiwan. In J Biol Chem, Sep 2015
DMC1 and RAD51 are conserved recombinases that catalyze homologous recombination.
AAA-ATPase FIDGETIN-LIKE 1 and Helicase FANCM Antagonize Meiotic Crossovers by Distinct Mechanisms.
New
Mercier et al., Versailles, France. In Plos Genet, Jul 2015
We show that Arabidopsis FIGL1 limits CO formation genome-wide, that FIGL1 controls dynamics of the two conserved recombinases DMC1 and RAD51 and that FIGL1 hinders the interaction between homologous chromosomes, suggesting that FIGL1 counteracts DMC1/RAD51-mediated inter-homologue strand invasion to limit CO formation.
DNA methylation restrains transposons from adopting a chromatin signature permissive for meiotic recombination.
New
Bourc'his et al., Paris, France. In Genes Dev, Jul 2015
Indeed, H3K4me3 marks gained over transcriptionally active transposons correlate with formation of SPO11-dependent double-strand breaks and recruitment of the DMC1 repair enzyme in Dnmt3L(-/-) meiotic cells, whereas these features are normally exclusive to meiotic recombination hot spots.
Identification of the meiotic toolkit in diatoms and exploration of meiosis-specific SPO11 and RAD51 homologs in the sexual species Pseudo-nitzschia multistriata and Seminavis robusta.
Ferrante et al., Napoli, Italy. In Bmc Genomics, 2014
While these include the majority of known meiosis-related genes, several meiosis-specific genes, including DMC1, could not be identified.
On the role of AtDMC1, AtRAD51 and its paralogs during Arabidopsis meiosis.
Review
Santos et al., Madrid, Spain. In Front Plant Sci, 2013
Many studies, mostly in yeast, have provided important insights into the coordination and interplay between the proteins involved in the homologous recombination pathway, especially the recombinase RAD51 and the meiosis-specific DMC1.
Arabidopsis meiotic crossover hot spots overlap with H2A.Z nucleosomes at gene promoters.
Impact
Henderson et al., Cambridge, United Kingdom. In Nat Genet, 2013
During meiosis, H2A.Z forms overlapping chromosomal foci with the DMC1 and RAD51 recombinases.
Rad51 is an accessory factor for Dmc1-mediated joint molecule formation during meiosis.
Impact
GeneRIF
Bishop et al., Chicago, United States. In Science, 2012
study provides biochemical evidence that Rad51 acts as an accessory factor with Mei5-Sae3 for Dmc1-mediated joint molecule formation during meiosis; Rad51 is a multifunctional protein that catalyzes recombination directly in mitosis and indirectly, via Dmc1, during meiosis
Saccharomyces cerevisiae Dmc1 and Rad51 proteins preferentially function with Tid1 and Rad54 proteins, respectively, to promote DNA strand invasion during genetic recombination.
GeneRIF
Kowalczykowski et al., Davis, United States. In J Biol Chem, 2012
Rad51-Rad54 function together to promote intersister DNA strand exchange, whereas Dmc1-Tid1 tilt the bias toward interhomolog DNA strand exchange.
The recombinases DMC1 and RAD51 are functionally and spatially separated during meiosis in Arabidopsis.
GeneRIF
Schlögelhofer et al., Vienna, Austria. In Plant Cell, 2012
Results demonstrate that DMC1 functions independently and spatially separated from RAD51 during meiosis and that ATR is an integral part of the regular meiotic program.
Homeostatic control of recombination is implemented progressively in mouse meiosis.
Impact
GeneRIF
Jasin et al., New York City, United States. In Nat Cell Biol, 2012
The DMC1 was highly variable from cell to cell, whereas foci of the crossover marker MLH1 showed little variability.
Reverse breeding in Arabidopsis thaliana generates homozygous parental lines from a heterozygous plant.
Impact
Dirks et al., Wageningen, Netherlands. In Nat Genet, 2012
We silenced DMC1, which encodes the meiotic recombination protein DISRUPTED MEIOTIC cDNA1, in hybrids of A. thaliana, so that non-recombined parental chromosomes segregate during meiosis.
Differing requirements for RAD51 and DMC1 in meiotic pairing of centromeres and chromosome arms in Arabidopsis thaliana.
GeneRIF
White et al., Clermont-Ferrand, France. In Plos Genet, 2011
Establishment and stabilisation of pairing of homologous centromeric and pericentromeric regions depends principally upon DMC1, while pairing and synapsis of euchromatic chromosome arms of homologues requires the presence of RAD51 .
Distinct properties of the XY pseudoautosomal region crucial for male meiosis.
Impact
Jasin et al., New York City, United States. In Science, 2011
Most PARs show delayed appearance of RAD51/DMC1 foci, which mark DSB ends, and all PARs undergo delayed DSB-mediated homologous pairing.
BRCA2: a universal recombinase regulator.
Review
West et al., London, United Kingdom. In Oncogene, 2008
Recent observations indicate that BRCA2 also plays a critical role in meiotic recombination, this time through direct interactions with the meiosis-specific recombinase DMC1.
Double-stranded DNA breaks and gene functions in recombination and meiosis.
Review
Ma et al., United States. In Cell Res, 2006
Processing of these sites of DSBs requires the function of RecA homologs, such as RAD51, DMC1, and others, as suggested by mutant studies; thus the failure to repair these meiotic DSBs results in abnormal chromosomal alternations, leading to disrupted meiosis.
Role of recA/RAD51 family proteins in mammals.
Review
Nishibori et al., Okayama, Japan. In Acta Med Okayama, 2005
In mammals, 7 recA-like genes have been identified: RAD51, RAD51L1/B, RAD51L2/C, RAD51L3/D, XRCC2, XRCC3, and DMC1.
Pch2 links chromatin silencing to meiotic checkpoint control.
Impact
Roeder et al., New Haven, United States. In Cell, 1999
Mutation of PCH2 relieves the checkpoint-induced pachytene arrest of the zip1, zip2, and dmc1 mutants, resulting in chromosome missegregation and low spore viability.
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