DMAP1 is an essential regulator of ATM activity and function.
London, United Kingdom. In Oncogene, 2014
DNMT1-associated protein 1 (DMAP1) is a member of the TIP60-p400 histone acetyl transferase (HAT) complex, which acetylates histone H4 at lysine 16 (H4K16) to affect chromatin relaxation and modulate ATM activation.
Epigenetic modification of FOXP3 in patients with chronic HIV infection.
Cincinnati, United States. In J Acquir Immune Defic Syndr, 2014
Expression of DNA methyltransferase 1 (DNAMT1), DNA methyltransferase 1-associated protein 1(DMAP1), methyltransferase-like 7B (METTL7B), and methyltransferase-like 10 (METTL10) were significantly down regulated in HIV-infected patients compared with controls and had a significant positive correlation to FOXP3 promoter methylation.
Distinct roles of DMAP1 in mouse development.
Pittsburgh, United States. In Mol Cell Biol, 2011
Consistent with the phenotypes of loss of other members of the TIP60-p400 complex, Dmap1(-/-) mice died during preimplantation in both Dnmt1(+/+) and Dnmt1(V)(/)(V) backgrounds.
DNA methylation, nuclear structure, gene expression and cancer.
Berlin, Germany. In J Cell Biochem Suppl, 1999
Most recently, also complexes of DNA methyltransferase (Dnmt1) with transcriptional repressors, DMAP1 and pRB, have been described providing a direct link to transcriptional regulation and tumor suppression.