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DNA methyltransferase 1 associated protein 1

DMAP1, Dnmt1-associated protein 1
This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: DNA methyltransferase, Histone, p53, V1a, PCNA
Papers on DMAP1
MDGA2 is a novel tumour suppressor cooperating with DMAP1 in gastric cancer and is associated with disease outcome.
Yu et al., Hong Kong, Hong Kong. In Gut, Aug 2015
The anti-tumorigenic effect of MDGA2 was mediated through direct stabilising of DNA methyltransferase 1 associated protein 1 (DMAP1), which played a tumour suppressive role in gastric cancer.
In silico docking of methyl isocyanate (MIC) and its hydrolytic product (1, 3-dimethylurea) shows significant interaction with DNA Methyltransferase 1 suggests cancer risk in Bhopal-Gas- Tragedy survivors.
Tiwari et al., Bhopāl, India. In Asian Pac J Cancer Prev, 2014
For the first time, we investigated the interaction of MIC and its hydrolytic product (1,3-dimethylurea) with DNMT1 interacting (such as DMAP1, RFTS, and CXXC) and catalytic (SAM, SAH, and Sinefungin) domains using computer simulations.
The chromatin regulator DMAP1 modulates activity of the nuclear factor B (NF-B) transcription factor Relish in the Drosophila innate immune response.
Hoffmann et al., In J Biol Chem, 2014
Here, we focus on DNA methyltransferase-associated protein 1 (DMAP1), which this study identified as an interactant of Relish, a Drosophila transcription factor reminiscent of the mammalian p105 NF-B protein.
Effects of topiramate on ethanol-cocaine interactions and DNA methyltransferase gene expression in the rat prefrontal cortex.
López-Moreno et al., Madrid, Spain. In Br J Pharmacol, 2014
Ethanol increased the gene expression of DNA methyltransferases (Dnmt1 and Dnmt3a), the corepressor Dnmt1-associated protein 1 (Dmap1), and the RNA methyltransferase Trdmt1.
Novel 1p tumour suppressor Dnmt1-associated protein 1 regulates MYCN/ataxia telangiectasia mutated/p53 pathway.
Kamijo et al., Chiba, Japan. In Eur J Cancer, 2014
In this study, we identified the role of Dnmt1-associated protein 1 (DMAP1), coded on chromosome 1p34, in the processes.
DMAP1 is an essential regulator of ATM activity and function.
Behrens et al., London, United Kingdom. In Oncogene, 2014
DNMT1-associated protein 1 (DMAP1) is a member of the TIP60-p400 histone acetyl transferase (HAT) complex, which acetylates histone H4 at lysine 16 (H4K16) to affect chromatin relaxation and modulate ATM activation.
Epigenetic modification of FOXP3 in patients with chronic HIV infection.
Shata et al., Cincinnati, United States. In J Acquir Immune Defic Syndr, 2014
Expression of DNA methyltransferase 1 (DNAMT1), DNA methyltransferase 1-associated protein 1(DMAP1), methyltransferase-like 7B (METTL7B), and methyltransferase-like 10 (METTL10) were significantly down regulated in HIV-infected patients compared with controls and had a significant positive correlation to FOXP3 promoter methylation.
Post-implantation mortality of in vitro produced embryos is associated with DNA methyltransferase 1 dysfunction in sheep placenta.
Loi et al., Teramo, Italy. In Hum Reprod, 2013
mRNA levels (for DNMT1, HDAC2, PCNA, DMAP1, MEST, IGF2, CDKN1C, H19) and the methylation status of H19 were also analyzed.
Specific inhibition of one DNMT1-including complex influences tumor initiation and progression.
Cartron et al., Nantes, France. In Clin Epigenetics, 2012
In contrast, a peptide disrupting the DNMT1/DMAP1 interaction, which per se did not affect tumor growth, sensitized cancer cells to chemotherapy/irradiation-induced cell death.
Regulation of SNAIL1 and E-cadherin function by DNMT1 in a DNA methylation-independent context.
Esteller et al., Madrid, Spain. In Nucleic Acids Res, 2011
We report that PCNA and DMAP1 domains in the N-terminal region of DNMT1 are sufficient to modulate E-cadherin expression in the absence of noticeable changes in DNA methylation patterns in the gene promoters involved.
Role of DNA methyltransferase 1 in pharyngeal cancer related to treatment resistance.
Chen et al., Taiwan. In Head Neck, 2011
positive staining for DNMT1 in clinical cancer specimens was significantly linked to lower rates of response to treatments and shorter survival of patients with pharyngeal cancer.
Distinct roles of DMAP1 in mouse development.
Chaillet et al., Pittsburgh, United States. In Mol Cell Biol, 2011
Consistent with the phenotypes of loss of other members of the TIP60-p400 complex, Dmap1(-/-) mice died during preimplantation in both Dnmt1(+/+) and Dnmt1(V)(/)(V) backgrounds.
Mitochondrial inhibition during preimplantation embryogenesis shifts the transcriptional profile of fetal mouse brain.
Lane et al., Adelaide, Australia. In Reprod Fertil Dev, 2010
Targeted qPCR assessment of a further 20 genes associated with methylation, acetylation and mitochondrial dysfunction revealed that three were significantly altered (Immp1l, Nars2, Sat2) and Dmap1 exhibited a sex-specific response to AOA exposure.
DNA methyltransferase 1-associated protein (DMAP1) is a co-repressor that stimulates DNA methylation globally and locally at sites of double strand break repair.
Muller et al., Orlando, United States. In J Biol Chem, 2010
Knocking down DMAP1 caused hypomethylation of the DNA repair products.
Corepressor MMTR/DMAP1 is an intrinsic negative regulator of CAK kinase to regulate cell cycle progression.
Kim et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2010
MMTR is an intrinsic negative cell cycle regulator that modulates the CAK kinase activity via interaction with MAT1.
Localization of DNA methyltransferase-1 during oocyte differentiation, in vitro maturation and early embryonic development in cow.
Luciano et al., Milano, Italy. In Eur J Histochem, 2010
Localization of DNA methyltransferase-1 during oocyte differentiation, in vitro maturation and early embryonic development in cow.(
DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci.
Baylin et al., Baltimore, United States. In Nat Genet, 2000
The non-catalytic amino terminus of DNMT1 binds to HDAC2 and a new protein, DMAP1 (for DNMT1 associated protein), and can mediate transcriptional repression.
DNA methylation, nuclear structure, gene expression and cancer.
Cardoso et al., Berlin, Germany. In J Cell Biochem Suppl, 1999
Most recently, also complexes of DNA methyltransferase (Dnmt1) with transcriptional repressors, DMAP1 and pRB, have been described providing a direct link to transcriptional regulation and tumor suppression.
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