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Delta-like 3

Dlx5, Delta3, DLL3
This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, delta4, delta1, fibrillin-1
Papers using Dlx5 antibodies
Design and validation of a tool for neurite tracing and analysis in fluorescence microscopy images
Supplier
Chao Moses V. et al., In Nature neuroscience, 2003
... Time-pregnant Sprague-Dawley rats, CD1 mice (Charles River Laboratories), Dlx5/6-Flpe and RCE:FRT transgenic mice ...
Papers on Dlx5
Alteration in the expression of antioxidant and detoxification genes in Chironomus riparius exposed to zinc oxide nanoparticles.
New
Chung et al., Seoul, South Korea. In Comp Biochem Physiol B Biochem Mol Biol, 13 Sep 2015
The expression of CuZn superoxide dismutase, manganese superoxide dismutase, catalase, phospholipid hydroperoxide glutathione peroxidase, thioredoxin reductase 1 and delta-3, sigma-4 and epsilon-1 classes of glutathione S-transferases, cytochrome p4509AT2 and heat shock protein 70 were studied using real-time polymerase chain reaction method.
Improved properties of bone and cartilage tissue from 3D inkjet-bioprinted human mesenchymal stem cells by simultaneous deposition and photocrosslinking in PEG-GelMA.
New
Cui et al., Wuhan, China. In Biotechnol Lett, 22 Aug 2015
Both osteogenic and chondrogenic differentiation as determined by specific gene and protein expression analysis (RUNX2, SP7, DLX5, ALPL, Col1A1, IBSP, BGLAP, SPP1, Col10A1, MMP13, SOX9, Col2A1, ACAN) was improved by PEG-GelMA in comparison to PEG alone.
Expression of imprinted genes in placenta is associated with infant neurobehavioral development.
New
Marsit et al., United States. In Epigenetics, 22 Aug 2015
Data reduction identified ten genes (DLX5, DHCR24, VTRNA2-1, PHLDA2, NPAP1, FAM50B, GNAS-AS1, PAX8-AS1, SHANK2, and COPG2IT1) whose expression could distinguish between newborn neurobehavioral profiles derived from the NNNS.
Effect of Alendronate on Bone Formation during Tooth Extraction Wound Healing.
New
Yamashita et al., Ann Arbor, United States. In J Dent Res, 29 Jul 2015
Genes associated with bone morphogenetic protein signaling, such as bmp2, nog, and dlx5, were activated in the extraction wounds of the ALN-treated animals.
Meta-analysis reveals the correlation of Notch signaling with non-small cell lung cancer progression and prognosis.
New
Wu et al., Wuhan, China. In Sci Rep, Dec 2014
Furthermore, there are statistically significant association between overall survival of NSCLC patients and the expression of Notch signaling ligand DLL3 and target gene HES1.
Downregulation of notch signaling pathway in late preterm and term placentas from pregnancies complicated by preeclampsia.
New
Spandidos et al., Irákleion, Greece. In Plos One, Dec 2014
On the contrary, NOTCH2, NOTCH3, DLL3, DLL4, JAG1, JAG2, HEY1 and HEY2 mRNA levels were downregulated in PE samples vs. controls (p<0.01).
7q21.3 Deletion involving enhancer sequences within the gene DYNC1I1 presents with intellectual disability and split hand-split foot malformation with decreased penetrance.
New
Velinov et al., New York City, United States. In Mol Cytogenet, Dec 2014
Genes considered to be associated with SHFM1 are DLX5 and DLX6.
Split-hand/foot malformation - molecular cause and implications in genetic counseling.
Review
New
Jamsheer et al., Poznań, Poland. In J Appl Genet, Feb 2014
In addition, three genes, i.e., TP63, WNT10B, and DLX5 are known to carry point mutations in patients affected by SHFM.
Possible roles of DLK1 in the Notch pathway during development and disease.
Review
Gaemers et al., Amsterdam, Netherlands. In Biochim Biophys Acta, 2012
In mammals, four Notch receptors (NOTCH1-4) and five activating canonical ligands (JAGGED1, JAGGED2, DLL1, DLL3 and DLL4) have been described.
Notch signaling in human development and disease.
Review
Spinner et al., Philadelphia, United States. In Semin Cell Dev Biol, 2012
Notch associated disorders include the autosomal dominant, multi-system, Alagille syndrome caused by mutations in both a ligand (Jagged1 (JAG1)) and receptor (NOTCH2) and autosomal recessive spondylocostal dysostosis, caused by mutations in a ligand (Delta-like-3 (DLL3)), as well as several other members of the Notch signaling pathway.
Rapp-Hodgkin syndrome and SHFM1 patients: delineating the p63-Dlx5/Dlx6 pathway.
GeneRIF
López-Expósito et al., Murcia, Spain. In Gene, 2012
Two patients that have in common a p63-Dlx5/Dlx6 pathway dysregulation.
Mutations in the Notch pathway alter the patterning of multifidus.
GeneRIF
Wilson-Rawls et al., Phoenix, United States. In Anat Rec (hoboken), 2012
Intriguing changes are observed in the cranio-caudal borders of multifidus muscle in mutant Dll3 and Lfng models of idiopathic scoliosis.
Identification of a novel DLX5 mutation in a family with autosomal recessive split hand and foot malformation.
GeneRIF
Alkuraya et al., Riyadh, Saudi Arabia. In J Med Genet, 2012
the first intragenic DLX5 mutation in split hand and foot malformation is found; a potential dual role for DLX5 in limb development is suggested
[Changes in the expression of Dlx5, Msx2, and Dlx5/Msx2 in hPDLSCs loaded with cyclic tensile stress].
GeneRIF
Zhao et al., Chengdu, China. In Sichuan Da Xue Xue Bao Yi Xue Ban, 2011
Cyclic tensile stress may induce differentiation of periodontal ligament stem cells towards mineralized tissue cells by promoting Dlx5 mRNA expression and decreasing Msx2 expression.
Akt phosphorylates and regulates the function of Dlx5.
GeneRIF
Lee et al., Kwangju, South Korea. In Biochem Biophys Res Commun, 2011
These results suggest that Dlx5 is a novel target of Akt and that the activity of Dlx5 could be modulated by a novel mechanism involving Akt during osteoblast differentiation.
Spondylocostal Dysostosis, Autosomal Recessive
Review
(International Consortium for Vertebral Anomalies and Scoliosis) et al., Seattle, United States. In Unknown Journal, 2009
Subtypes are defined by identification of two mutant alleles in any one of the four genes in which mutations are known to cause autosomal recessive (AR) SCDO: DLL3, MESP2, LFNG, and HES7.
Defective somitogenesis and abnormal vertebral segmentation in man.
Review
Turnpenny, Exeter, United Kingdom. In Adv Exp Med Biol, 2007
Only a minority of abnormal segmentation phenotypes appear to follow Mendelian inheritance but three genes--DLL3, MESP2 and LNFG--have now been identified for spondylocostal dysostosis (SCD), a spinal malformation characterized by extensive hemivertebrae, trunkal shortening and abnormally aligned ribs with points of fusion.
Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis.
Impact
Aldape et al., San Francisco, United States. In Cancer Cell, 2006
A robust two-gene prognostic model utilizing PTEN and DLL3 expression suggests that Akt and Notch signaling are hallmarks of poor prognosis versus better prognosis gliomas, respectively.
Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome.
Impact
GeneRIF
Kohwi-Shigematsu et al., Berkeley, United States. In Nat Genet, 2005
Mecp2 regulates Dlx5 by means of a silent chromatin loop
Mutations in the human delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis.
Impact
Turnpenny et al., Exeter, United Kingdom. In Nat Genet, 2000
Dll3 is mutated in the X-ray-induced mouse mutant pudgy (pu), causing a variety of vertebrocostal defects similar to SD phenotypes.
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