gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Discs, large homolog 5

This gene encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure. Alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: NOD2, IBD, TLR4, CAN, IL23R
Papers on DLG5
Discs large 5, an Essential Gene in Drosophila, Regulates Egg Chamber Organization.
Steward et al., Princeton, United States. In G3 (bethesda), May 2015
Discs large 5 (Dlg5) is a member of the MAGUK family of proteins that typically serve as molecular scaffolds and mediate signaling complex formation and localization.
Loss of Dlg5 expression promotes the migration and invasion of prostate cancer cells via Girdin phosphorylation.
Kioka et al., Kyoto, Japan. In Oncogene, Mar 2015
Dlg5 has been reported to participate in cancer progression; however, its role in prostate cancer still remains poorly understood.
Methylation-mediated silencing of Dlg5 facilitates bladder cancer metastasis.
Qiu et al., Shanghai, China. In Exp Cell Res, Mar 2015
UNLABELLED: Dlg5 (Discs large homolog 5), a member of the membrane-associated guanylate kinase adaptor family of scaffolding proteins, has been shown to participate in cancer progression.
Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5.
Beachy et al., Stanford, United States. In Genes Dev, Mar 2015
In an effort to elucidate this mechanism, we identified Dlg5 (Discs large, homolog 5) in a biochemical screen for proteins that preferentially interact with activated Smo.
Dlg5 regulates dendritic spine formation and synaptogenesis by controlling subcellular N-cadherin localization.
Kolodkin et al., Seoul, South Korea. In J Neurosci, 2014
We isolated a novel disc large-5 (Dlg5) allele in mice, Dlg5(LP), which harbors a missense mutation in the DLG5 SH3 domain, greatly attenuating its ability to interact with the DLG5 GUK domain.
A comprehensive analysis of the human placenta transcriptome.
Shankar et al., Little Rock, United States. In Placenta, 2014
To identify genes that were highly expressed and unique to the placenta we compared placental RNA-seq data to data from 7 other tissues (adipose, breast, hear, kidney, liver, lung, and smooth muscle) and identified several genes novel to placental biology (QSOX1, DLG5, and SEMA7A).
DLG5 in cell polarity maintenance and cancer development.
Liu et al., Xi'an, China. In Int J Biol Sci, 2013
The polarity protein discs large homolog 5 (DLG5) belongs to a family of molecular scaffolding proteins called Membrane Associated Guanylate Kinases (MAGUKs).
NOD2 mutations affect muramyl dipeptide stimulation of human B lymphocytes and interact with other IBD-associated genes.
Koltun et al., Colón, Panama. In Dig Dis Sci, 2013
We revealed significant interactions of NOD2 with other IBD susceptibility genes IL23R, DLG5, and OCTN1.
Dlg5 interacts with the TGF-β receptor and promotes its degradation.
Kioka et al., Kyoto, Japan. In Febs Lett, 2013
Discs large homolog 5 (Dlg5) is a member of the membrane-associated guanylate kinase adaptor family of proteins and is involved in epithelial-to-mesenchymal transition via transforming growth factor-β (TGF-β) signaling.
TNF-alpha and melphalan modulate a specific group of early expressed genes in a murine melanoma model.
Dias et al., São Paulo, Brazil. In Cytokine, 2013
In our model we found that the treatments regulate genes that play important roles in tumorigenesis such as cell adhesion (Pard3, Pecam1, Ilk, and Dlg5), proliferation (Tcfe3 and Polr1e), cell motility (Kifap3, Palld, and Arhgef6), apoptosis (Bcl2l11), and angiogenesis (Flt1 and Ptprj).
Identification of DLG5 and SLC22A5 gene polymorphisms in Malaysian patients with Crohn's disease.
Goh et al., Kuala Lumpur, Malaysia. In J Dig Dis, 2011
Polymorphisms in the DLG5 gene were found to be associated with Crohn's disease patients in Malaysia.
Increased expression of discs large homolog 5 gene (DLG5) in ulcerative colitis patients compared to healthy individuals.
Barreto-Zuñiga et al., In Inflamm Bowel Dis, 2011
Increased expression of discs large homolog 5 gene is associated with ulcerative colitis.
DLG5 P1371Q is associated with inflammatory bowel disease and complementary to R30Q in disease susceptibility.
Koltun et al., United States. In Swiss Med Wkly, 2010
Examined the genetic association of DLG5 SNP P1371Q with inflammatory bowel disease and its interaction with R30Q in disease susceptibility. P1371Q is complementary to R30Q, with R30Q exhibiting a dominant effect in IBD susceptibility.
Discs large 5 is required for polarization of citron kinase in mitotic neural precursors.
LoTurco et al., United States. In Cell Cycle, 2010
Data report that Discs large 5 (Dlg5), a member of the MAGUK family, is an interactor of CitK required for CitK polarization.
Genetic association of DLG5 R30Q with familial and sporadic inflammatory bowel disease in men.
Koltun et al., United States. In Dis Markers, 2008
In the studied population, DLG5 R30Q was associated with all forms of IBD. An elevated presence of the R30Q variant was observed in all members of a familial IBD registry
The genetics of Crohn's disease.
Satsangi et al., Edinburgh, United Kingdom. In Annu Rev Genomics Hum Genet, 2008
These loci encode genes involved in a number of homeostatic mechanisms: innate pattern recognition receptors (NOD2/CARD15, TLR4, CARD9), the differentiation of Th17-lymphocytes (IL-23R, JAK2, STAT3, CCR6, ICOSLG), autophagy (ATG16L1, IRGM, LRRK2), maintenance of epithelial barrier integrity (IBD5, DLG5, PTGER4, ITLN1, DMBT1, XBP1), and the orchestration of the secondary immune response (HLA-region, TNFSF15/TL1A, IRF5, PTPN2, PTPN22, NKX2-3, IL-12B, IL-18RAP, MST1).
The role of genetics in inflammatory bowel disease.
Sans et al., Leuven, Belgium. In Curr Drug Targets, 2008
Genome-wide linkage studies pointed towards more than 10 chromosomal regions and fine-mapping of these regions led to the identification of a number of genes, including CARD15 (NOD2), DLG5, OCTN1 and 2, TLR4 and CARD4 (NOD1).
Review article: Inflammatory bowel disease and genetics.
Dijkstra et al., Groningen, Netherlands. In Aliment Pharmacol Ther, 2007
Promising candidate genes include TLR4, MDR1, NOD1 (CARD4), DLG5 as well as the IBD5 locus including SLC22A4/5.
Genes, diet and inflammatory bowel disease.
Petermann et al., Auckland, New Zealand. In Mutat Res, 2007
Other implicated genes may affect mucosal cell polarity (Drosophila discs large homologue 5, DLG5) or mucosal transporter function (sodium dependent organic cation transporters, SLC22A4 and SLC22A5).
Genetic variation in DLG5 is associated with inflammatory bowel disease.
Schreiber et al., Kiel, Germany. In Nat Genet, 2004
Genetic variation in DLG5 is associated with inflammatory bowel disease
share on facebooktweetadd +1mail to friends