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StAR-related lipid transfer

DLC2, dynein light chain 2, STARD13, Rho-GTPase activating protein
This gene encodes a protein which contains an N-terminal sterile alpha motif (SAM) for protein-protein interactions, followed by an ATP/GTP-binding motif, a GTPase-activating protein (GAP) domain, and a C-terminal STAR-related lipid transfer (START) domain. It may be involved in regulation of cytoskeletal reorganization, cell proliferation, and cell motility, and acts as a tumor suppressor in hepatoma cells. The gene is located in a region of chromosome 13 that is associated with loss of heterozygosity in hepatocellular carcinomas. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: Rhodopsin, RhoGAP, GAP, Actin, RhoA
Papers on DLC2
The neuritogenic and synaptogenic effects of the ethanolic extract of radix Puerariae in cultured rat hippocampal neurons.
New
Moon et al., Kyŏngju, South Korea. In J Ethnopharmacol, Oct 2015
Proteomic study revealed that RPE and puerarin both up-regulated a number of proteins, including dynein light chain 2 (DLC2) and elongation factor 2 (EF2), which are associated with neuritogenesis and synaptic potentiation, respectively.
Fasted/fed states regulate postsynaptic hub protein DYNLL2 and glutamatergic transmission in oxytocin neurons in the hypothalamic paraventricular nucleus.
New
Yada et al., Tochigi, Japan. In Neuropeptides, Sep 2015
In Oxt neurons, dynein light chain 2 (DYNLL2), a protein suggested to be implicated in the NMDA receptor trafficking to the postsynaptic site, was increased under fed, compared to fasted, condition.
CDK5 is a major regulator of the tumor suppressor DLC1.
Lowy et al., Cambridge, United States. In J Cell Biol, 2015
DLC1 is a tumor suppressor protein whose full activity depends on its presence at focal adhesions, its Rho-GTPase activating protein (Rho-GAP) function, and its ability to bind several ligands, including tensin and talin.
Promising Loci and Genes for Yolk and Ovary Weight in Chickens Revealed by a Genome-Wide Association Study.
Yang et al., Beijing, China. In Plos One, 2014
A list of candidate genes such as ZAR1, STARD13, ACER1b, ACSBG2, and DHRS12 were identified for having a plausible function in yolk and follicle development.
Whole genome gene copy number profiling of gastric cancer identifies PAK1 and KRAS gene amplification as therapy targets.
Ji et al., Shanghai, China. In Genes Chromosomes Cancer, 2014
The analyses revealed gene focal amplifications, including CTSB, PRKCI, PAK1, STARD13, KRAS, and ABCC4, in addition to ERBB2, FGFR2, and MET.
The stoichiometry of scaffold complexes in living neurons - DLC2 functions as a dimerization engine for GKAP.
Perroy et al., Montpellier, France. In J Cell Sci, 2014
We have investigated in living neurons the spatial dependence of the stoichiometry of interactions between two core proteins of the N-methyl-D-aspartate (NMDA)-receptor-associated scaffolding complex, GKAP (also known as DLGAP1) and DLC2 (also known as DYNLL2), using a novel variation of fluorescence fluctuation microscopy called two-photon scanning number and brightness (sN&B).
Dendritic cell motility and T cell activation requires regulation of Rho-cofilin signaling by the Rho-GTPase activating protein myosin IXb.
Grabbe et al., Münster, Germany. In J Immunol, 2014
Directed migration of stimulated dendritic cells (DCs) to secondary lymphoid organs and their interaction with Ag-specific T cells is a prerequisite for the induction of primary immune responses.
Utilizing the Dyn2 dimerization-zipper as a tool to probe NPC structure and function.
Hurt et al., Heidelberg, Germany. In Methods Cell Biol, 2013
The discovery of dynein light chain 2 (Dyn2) as a member of the nucleoporins in yeast led to a series of applications to study NPC structure and function.
A miRNA signature of chemoresistant mesenchymal phenotype identifies novel molecular targets associated with advanced pancreatic cancer.
Freeman et al., San Antonio, United States. In Plos One, 2013
Moreover, RNA-seq data from each of 40 advanced PDAC tumor specimens from the TCGA data base indicate a negative correlation between expression of miRNA-125b and five of six potential target genes (BAP1, BBC3, NEU1, BCL2, STARD13).
The tumour suppressor DLC2 ensures mitotic fidelity by coordinating spindle positioning and cell-cell adhesion.
Matter et al., Porto, Portugal. In Nat Commun, 2013
Here we demonstrate that the tumour suppressor DLC2, a negative regulator of Cdc42, and the interacting kinesin Kif1B coordinate cell junction maintenance and planar spindle positioning by regulating microtubule growth and crosstalk with the actin cytoskeleton.
The STAR of the DLC family.
Review
El-Sibai et al., Beirut, Lebanon. In J Recept Signal Transduct Res, 2012
STARD13, a GTPase activating protein (GAP) for RhoGTPases, has been described as a tumor suppressor in hepatocellular carcinoma.
The RhoA GTPase-activating protein DLC2 modulates RhoA activity and hyperalgesia to noxious thermal and inflammatory stimuli.
GeneRIF
Chung et al., Hong Kong, Hong Kong. In Neurosignals, 2011
DLC2 plays a key role in pain modulation during inflammation by suppressing the activation of RhoA and ERK to prevent an exaggerated pain response
MicroRNA-125b induces metastasis by targeting STARD13 in MCF-7 and MDA-MB-231 breast cancer cells.
GeneRIF
Xi et al., Nanjing, China. In Plos One, 2011
role of miR-125b in pro-metastasis by targeting STARD13
Affinity, avidity, and kinetics of target sequence binding to LC8 dynein light chain isoforms.
GeneRIF
Nyitray et al., Budapest, Hungary. In J Biol Chem, 2011
the thermodynamic and kinetic fine-tuning of binding of various ligands to DYNLL could have physiological relevance in its interaction network.
Deleted in liver cancer 2 suppresses cell growth via the regulation of the Raf-1-ERK1/2-p70S6K signalling pathway.
GeneRIF
Ng et al., Hong Kong, Hong Kong. In Liver Int, 2010
DLC2 inhibits the activity of Raf-1-ERK1/2-p70S6K via its RhoGAP function, resulting in the suppression of cell growth.
DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration.
GeneRIF
Lo et al., Sacramento, United States. In Oncogene, 2010
DLC2-mutant mice display enhanced angiogenic responses.
Genome-wide association study of intracranial aneurysm identifies three new risk loci.
Impact
Günel et al., New Haven, United States. In Nat Genet, 2010
P = 1.1 x 10(-12)), STARD13-KL on 13q13.1 (OR = 1.20,
DLC-1:a Rho GTPase-activating protein and tumour suppressor.
Review
Popescu et al., Bethesda, United States. In J Cell Mol Med, 2007
Two closely related genes, DLC-2 and DLC-3, may also be tumour suppressors.
Cytokinesis: closing in on the central spindle.
Review
Bowerman et al., Eugene, United States. In Dev Cell, 2002
Genetic and biochemical approaches have identified a tetrameric complex, made up of a mitotic kinesin-like protein and a Rho-GTPase activating protein, that mediates central spindle assembly.
Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis.
Impact
Strasser et al., Melbourne, Australia. In Science, 2001
In healthy cells, Bmf is sequestered to myosin V motors by association with dynein light chain 2. Certain damage signals, such as loss of cell attachment (anoikis), unleash Bmf, allowing it to translocate and bind prosurvival Bcl-2 proteins.
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