CDK5 is a major regulator of the tumor suppressor DLC1.
Cambridge, United States. In J Cell Biol, 2015
DLC1 is a tumor suppressor protein whose full activity depends on its presence at focal adhesions, its Rho-GTPase activating protein (Rho-GAP) function, and its ability to bind several ligands, including tensin and talin.
Whole genome gene copy number profiling of gastric cancer identifies PAK1 and KRAS gene amplification as therapy targets.
Shanghai, China. In Genes Chromosomes Cancer, 2014
The analyses revealed gene focal amplifications, including CTSB, PRKCI, PAK1, STARD13, KRAS, and ABCC4, in addition to ERBB2, FGFR2, and MET.
The STAR of the DLC family.
Beirut, Lebanon. In J Recept Signal Transduct Res, 2012
STARD13, a GTPase activating protein (GAP) for RhoGTPases, has been described as a tumor suppressor in hepatocellular carcinoma.
Cytokinesis: closing in on the central spindle.
Eugene, United States. In Dev Cell, 2002
Genetic and biochemical approaches have identified a tetrameric complex, made up of a mitotic kinesin-like protein and a Rho-GTPase activating protein, that mediates central spindle assembly.