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Dickkopf 2 homolog

Dkk2, Dickkopf2
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: DKK1, p29, SFRP1, SFRP2, DKK4
Papers on Dkk2
Association of Wnt signaling pathway genetic variants in gallbladder cancer susceptibility and survival.
Mittal et al., Lucknow, India. In Tumour Biol, Jan 2016
In this study, we assessed the association of common germline variants of Wnt pathway genes (SFRP2, SFRP4, DKK2, DKK3, WISP3, APC, β-catenin, AXIN-2, GLI-1) to evaluate their contribution in predisposition to GBC and treatment outcomes.
Significant Association Between Polymorphisms of Wnt Antagonist Genes and Lung Cancer.
Kilickap et al., Ankara, Turkey. In J Investig Med, Dec 2015
Single-nucleotide polymorphisms of Wnt antagonist genes including DKK2 (rs17037102), DKK3 (rs3206824), DKK3 intron4 G/C (rs7396187), DKK4 (rs2073664), and sFRP4 (rs1802074) were analyzed using nested polymerase chain reaction and restriction fragment length polymorphism.
Human breast cancer bone metastasis in vitro and in vivo: a novel 3D model system for studies of tumour cell-bone cell interactions.
Ottewell et al., Sheffield, United Kingdom. In Clin Exp Metastasis, Oct 2015
MDA-MB-231 cells grown in human bone discs showed increased expression of IL-1B, HRAS and MMP9 and decreased expression of S100A4, whereas, DKK2 and FN1 were unaltered compared with the same cells grown in mammary fat pads of mice not implanted with human bone discs.
Toxicity of doxorubicin-transferrin conjugate is connected to the modulation of Wnt/β-catenin pathway in human leukemia cells.
Jozwiak et al., Łódź, Poland. In Leuk Res, Oct 2015
Moreover, by the of engagement of Wnt pathway agonist (LiCl) and antagonist (ICG 001) we demonstrate that DOX-TRF conjugate effectively reduces transcription of key genes involved in β-catenin signaling transduction trial (Wnt3a, DVL-1, FZD-3, LRP5, β-catenin, DKK2) and triggers morphology alternations of CML cells.
Mutant screening for oncogenes of Ewing's sarcoma using yeast.
Nakamura et al., Ube, Japan. In Appl Microbiol Biotechnol, Aug 2015
Moreover, mutants also showed reduced transcriptional activities on the DKK2 promoter, which is upregulated by the EWS/ETS family, compared to that of the wild type.
Gene expression profiling of MYC-driven tumor signatures in porcine liver stem cells by transcriptome sequencing.
Steer et al., Minneapolis, United States. In World J Gastroenterol, Mar 2015
Interestingly, six genes expressed by PICM-19 cells (CDO1, C22orf39, DKK2, ENPEP, GPX6, SRPX2) were completely silenced after MYC-induction in PICM-19-CSCs, suggesting that the absence of these genes may be critical for inducing tumorigenesis.
The transcription factor ccaat/enhancer binding protein β (C/EBPβ) and miR-27a regulate the expression of porcine Dickkopf2 (DKK2).
Li et al., Wuhan, China. In Sci Rep, 2014
Using Affymetrix porcine Gene-Chip analyses, we found that Dickkopf2 (DKK2), a WNT antagonist, is differentially expressed in pre-ovulatory follicles between Large White and Chinese Taihu sows.
Characterization of the nasopharyngeal carcinoma methylome identifies aberrant disruption of key signaling pathways and methylated tumor suppressor genes.
Tao et al., Hong Kong, Hong Kong. In Epigenomics, 2014
Methylation of Wnt signaling regulators (SFRP1, 2, 4 and 5, DACT2, DKK2 and DKK3) was frequently detected in tumor and nasal swab samples from NPC patients.
Identification of two populations of osteoarthritic osteoblasts according to the 1,25[OH]₂ vitamin D₃ potency to stimulate osteocalcin.
Reboul et al., Vandœuvre-lès-Nancy, France. In Biomed Mater Eng, 2014
Osteocalcin (OCN), TGF-β1, Dickkopf-related protein 2 (DKK2), R-spondin 2 (Rspo2), Wnt5b, and low density lipoprotein related-receptor 1 (LRP1) were evaluated by real time RT-PCR.
The homeodomain transcription factor PITX2 is required for specifying correct cell fates and establishing angiogenic privilege in the developing cornea.
Zacharias et al., Ann Arbor, United States. In Dev Dyn, 2014
Further, the expression of Dkk2 and suppression of canonical Wnt signaling activity levels are key mechanisms by which PITX2 specifies ocular surface ectoderm as cornea.
Integration of prior biological knowledge and epigenetic information enhances the prediction accuracy of the Bayesian Wnt pathway.
Sinha, Nijmegen, Netherlands. In Integr Biol (camb), 2014
Hitherto unknown relationship between factors like DKK2, DKK3-1 and SFRP-2/3/5 w.r.t. the β-catenin transcription complex has been inferred using these causal models.
Analysis of DNA methylation in bowel lavage fluid for detection of colorectal cancer.
Suzuki et al., Sapporo, Japan. In Cancer Prev Res (phila), 2014
Methylation of 15 genes (miR-1-1, miR-9-1, miR-9-3, miR-34b/c, miR-124-1, miR-124-2, miR-124-3, miR-137, SFRP1, SFRP2, APC, DKK2, WIF1, LOC386758, and ZNF582) was then analyzed in MethyLight assays, after which receiver operating characteristic (ROC) curves were analyzed to assess the diagnostic performance of BLF methylation.
Dysregulated expression of dickkopfs for potential detection of hepatocellular carcinoma.
Lee et al., Hong Kong, Hong Kong. In Expert Rev Mol Diagn, 2014
Although DKK1 offers potential for its use in HCC diagnosis this review will discuss the challenges facing DKK1 and also shed some light on recent developments on the remaining DKK family members: DKK2, DKK3 and DKK4.
Boosting Wnt activity during colorectal cancer progression through selective hypermethylation of Wnt signaling antagonists.
Ibrahim et al., Cambridge, United Kingdom. In Bmc Cancer, 2013
RESULTS: We discovered widespread hypermethylation of the Wnt antagonists SFRP1, SFRP2, SFRP5, DKK2, WIF1 and SOX17 in the transition from normal to adenoma with only the Wnt antagonists SFRP1, SFRP2, DKK2 and WIF1 showing further significant increase in methylation from adenoma to carcinoma.
Hypoxia and vitamin D differently contribute to leptin and dickkopf-related protein 2 production in human osteoarthritic subchondral bone osteoblasts.
Reboul et al., In Arthritis Res Ther, 2013
Among several factors potentially involved, leptin and dickkopf-related protein 2 (DKK2) are good candidates since they are up-regulated in OA osteoblasts (Obs).
Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism.
Wu et al., New Haven, United States. In Proc Natl Acad Sci U S A, 2012
Dickkopf2 is a Wnt antagonist involved in regulation of glucose metabolism
Dkk1 and Dkk2 regulate epicardial specification during mouse heart development.
Westphal et al., Bethesda, United States. In Int J Cardiol, 2011
Both Dkk1 and Dkk2 inhibit Wnt signaling that regulates early myocardial proliferation; each compensates for loss of the other in that role.
Elevated Dickkopf-2 levels contribute to the abnormal phenotype of human osteoarthritic osteoblasts.
Lajeunesse et al., Montréal, Canada. In J Bone Miner Res, 2011
Elevated TGF-beta1 levels in osteoarthritic osteoblasts can stimulate DKK2 expression.
The WNT antagonist Dickkopf2 promotes angiogenesis in rodent and human endothelial cells.
Kwon et al., Seoul, South Korea. In J Clin Invest, 2011
there are distinct functions of DKK1 and DKK2 in controlling angiogenesis
A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.
Riley et al., Richmond, United States. In Hum Mol Genet, 2010
In the study of the genetics of alcoholism, three SNPs in DKK2 (rs427983; rs419558; rs399087) demonstrated empirical significance.
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