Early and sustained changes in bone metabolism after severe burn injury.
Vienna, Austria. In J Clin Endocrinol Metab, Feb 2016
During the early phase pronounced increases were observed for CTX, P1NP, sclerostin, DKK-1, BALP, FGF23 and iPTH levels, whereas 25-OH vitamin D, albumin, serum and ionized calcium levels decreased.
Wnt/β-catenin signaling plays a key role in the development of spondyloarthritis.
Shenyang, China. In Ann N Y Acad Sci, Jan 2016
Recent clinical observations and animal studies demonstrate that Wnt signaling proteins and natural Wnt inhibitors, such as DKK1 and sclerostin, are likely to play important roles in the process of ankylosis in SpA, and could potentially serve as therapeutic targets for the treatment of SpA.
Novel therapies for osteoporosis.
Athens, Greece. In Metabolism, Oct 2015
Several other agents are currently in earlier clinical and preclinical phases of development, including dickkopf-1 antagonists, activin A antagonists, β-arrestin analogs, calcilytics, and Src tyrosine kinase inhibitors.
Dickkopf-1 expression is a novel prognostic marker for gastric cancer.
Nanjing, China. In J Biomed Biotechnol, 2011
Dickkopf-1 expression levels were significantly upregulated in gastric cancer lesions compared with adjacent noncancerous tissues, and level correlated with depth of invasion, vessel invasion, lymph node and distant metastasis, and TNM stage of tumors.