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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Dickkopf 1 homolog

DKK1, Dickkopf-1, Dickkopf
This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, sclerostin, V1a, HAD, AGE
Papers using DKK1 antibodies
beta-catenin plays a key role in metastasis of human hepatocellular carcinoma
Wong Chun-Ming, In PLoS ONE, 2010
... hDKK1 neutralizing antibody was purchased from R&D Systems (Minneapolis, MN) while DKK1 detection antibody was purchased from Abcam (Cambridge, MA) ...
Novel expression profiles and invasiveness-related biology function of DKK1 in endometrial carcinoma
Catalano Rob D. et al., In Molecular Human Reproduction, 2008
... DKK1 monoclonal antibody (M11, clone 2A5) and recombinant protein were purchased from Abnova Corp ...
Papers on DKK1
Early and sustained changes in bone metabolism after severe burn injury.
Muschitz et al., Vienna, Austria. In J Clin Endocrinol Metab, Feb 2016
During the early phase pronounced increases were observed for CTX, P1NP, sclerostin, DKK-1, BALP, FGF23 and iPTH levels, whereas 25-OH vitamin D, albumin, serum and ionized calcium levels decreased.
Controversies regarding and perspectives on clinical utility of biomarkers in hepatocellular carcinoma.
Tang et al., Tokyo, Japan. In World J Gastroenterol, Feb 2016
Other biomarkers, including the Lens culinaris agglutinin-reactive fraction of AFP (AFP-L3), des-γ-carboxyprothrombin, Dickkopf-1, midkine, and microRNA, are being studied in this regard.
Wnt/β-catenin signaling plays a key role in the development of spondyloarthritis.
Chen et al., Shenyang, China. In Ann N Y Acad Sci, Jan 2016
Recent clinical observations and animal studies demonstrate that Wnt signaling proteins and natural Wnt inhibitors, such as DKK1 and sclerostin, are likely to play important roles in the process of ankylosis in SpA, and could potentially serve as therapeutic targets for the treatment of SpA.
The Wnt inhibitor dickkopf-1: a link between breast cancer and bone metastases.
Erich-Franz et al., Homburg, Germany. In Clin Exp Metastasis, Dec 2015
Overexpression of dickkopf-1 (Dkk1) protein, a negative regulator of the Wnt/β-catenin pathway, has been found in breast cancer cell lines that form osteolytic metastases preferentially and in serum from breast cancer patients with osteolytic bone metastases.
Increased Dickkopf-1 in Recent-onset Rheumatoid Arthritis is a New Biomarker of Structural Severity. Data from the ESPOIR Cohort.
Miceli-Richard et al., Le Kremlin-Bicêtre, France. In Sci Rep, Dec 2015
Here, we investigated Dickkopf-1 (DKK-1) and sclerostin (SOST) serum levels in patients with recent inflammatory arthritis from the ESPOIR cohort.
DKK1 expression by synovial fibroblasts in very early rheumatoid arthritis associates with lymphocyte adhesion in an in vitro flow co-culture system.
Filer et al., Birmingham, United Kingdom. In Arthritis Res Ther, Dec 2015
We investigated the role of Dickkopf-related protein 1 (DKK1) produced by synovial fibroblasts of patients with very early rheumatoid arthritis (VeRA).
Focal bone involvement in inflammatory arthritis: the role of IL17.
Gatti et al., Verona, Italy. In Rheumatol Int, Dec 2015
It acts by both triggering OC bone erosion via the RANK-RANKL system, and suppressing OB bone formation through the overexpression of DKK1, a powerful inhibitor of the WNT bone anabolic signaling pathway.
Novel therapies for osteoporosis.
Anastasilakis et al., Athens, Greece. In Metabolism, Oct 2015
Several other agents are currently in earlier clinical and preclinical phases of development, including dickkopf-1 antagonists, activin A antagonists, β-arrestin analogs, calcilytics, and Src tyrosine kinase inhibitors.
Downregulation of serum DKK-1 predicts poor prognosis in patients with papillary thyroid cancer.
Zhang et al., China. In Genet Mol Res, 2014
The Wnt inhibitor dickkopf-1 (DKK-1) has been shown to be closely correlated with tumor initiation and progression in various types of cancers.
Serum Dickkopf-1 levels as a clinical and prognostic factor in patients with bladder cancer.
Zhang et al., Yantai, China. In Genet Mol Res, 2014
Dickkopf-1 (DKK-1) is a secreted protein that inhibits Wnt signaling.
Loss of Dickkopf-1 restores neurogenesis in old age and counteracts cognitive decline.
Martin-Villalba et al., Heidelberg, Germany. In Cell Stem Cell, 2013
Here, we show that expression of the Wnt antagonist Dickkopf-1 (Dkk1) increases with age and that its loss enhances neurogenesis in the hippocampus.
Sclerostin and Dickkopf-1 as therapeutic targets in bone diseases.
Ominsky et al., Thousand Oaks, United States. In Endocr Rev, 2012
The Wnt pathway plays an important role in bone formation and regeneration, and expression of two Wnt pathway inhibitors, sclerostin and Dickkopf-1 (DKK1), appears to be associated with changes in bone mass.
Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: a large-scale, multicentre study.
Qin et al., Shanghai, China. In Lancet Oncol, 2012
DKK1 could complement measurement of AFP in the diagnosis of hepatocellular carcinoma and improve identification of patients with AFP-negative HCC and distinguish HCC from non-malignant chronic liver diseases.
Circulating sclerostin and Dickkopf-1 (DKK1) in predialysis chronic kidney disease (CKD): relationship with bone density and arterial stiffness.
Hampson et al., London, United Kingdom. In Calcif Tissue Int, 2012
A negative association was seen between DKK1 and SI
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
Rivadeneira et al., Rotterdam, Netherlands. In Nat Genet, 2012
(LRP5), 4q22.1 (MEPE), 2p16.2 (SPTBN1) and 10q21.1 (DKK1).
The 39th David A. Karnofsky Lecture: bench-to-bedside translation of targeted therapies in multiple myeloma.
Anderson, Boston, United States. In J Clin Oncol, 2012
Moreover, agents targeting bone biology (eg, zoledronic acid, anti-DKK-1 MoAb, anti-B-cell activating factor MoAb and bortezomib, Btk inhibitor) show promise not only in preserving bone integrity but also against MM.
Dickkopf-1 expression is a novel prognostic marker for gastric cancer.
Yang et al., Nanjing, China. In J Biomed Biotechnol, 2011
Dickkopf-1 expression levels were significantly upregulated in gastric cancer lesions compared with adjacent noncancerous tissues, and level correlated with depth of invasion, vessel invasion, lymph node and distant metastasis, and TNM stage of tumors.
The structural basis of DKK-mediated inhibition of Wnt/LRP signaling.
Wu et al., Memphis, United States. In Sci Signal, 2011
Crystal structures of the LRP6 ectodomain in complex with DKK1, along with mutagenesis studies, provide considerable insights into the molecular basis for DKK-mediated inhibition and Wnt signaling through LRP5/6
Expression of dickkopf-1 and beta-catenin related to the prognosis of breast cancer patients with triple negative phenotype.
Shao et al., Shanghai, China. In Plos One, 2011
DKK1 together with beta-catenin might be important prognostic factors in triple negative breast carcinoma.
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