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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 24 Oct 2014.

Parkinson protein 7

DJ-1, PARK7
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: E3 ubiquitin ligase, PINK1, CAN, LRRK2, alpha-Synuclein
Papers using DJ-1 antibodies
Initial Development and Validation of a Novel Extraction Method for Quantitative Mining of the Formalin-Fixed, Paraffin-Embedded Tissue Proteome for Biomarker Investigations
Supplier
Lucacchini Antonio et al., In Proteome Science, 2010
... Anti-CCT-5, anti-PARK7 and anti-BSPRY specific primary antibodies were from the Abnova Corporation (Taiwan) ...
In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro.
Supplier
Vanacker Jean-Marc, In PLoS ONE, 2006
... CA), actin, phospho-Akt, Akt and PTEN antibodies (Santa Cruz, CA), Caspase-9 antibody (Millipore, Billerica, MA), DJ-1 antibody (MBL International, Woburn, MA), HRP ...
Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1
Supplier
Chen Shengdi et al., In Molecular Neurodegeneration, 2004
... The following antibodies were used: DJ-1 Monoclonal Antibody (3E8) (Assay Designs, ADI-KAM-SA100-E), mono- and polyubiquitinylated conjugates, monoclonal Antibody (FK2) (Biomol, BML-PW8810R), DJ-1 polyclonal antibody ...
Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition
Supplier
Abeliovich Asa et al., In PLoS Biology, 2002
... Transfections with plasmids encoding human Flag-WT DJ-1, PD-associated L166P mutant DJ-1, or vector alone, were performed using Lipofectamine 2000 (Life Technologies) for 18–36 h according to ...
Papers on DJ-1
A comparative proteomic study of Homoharringtonine-induced apoptosis in leukemia K562 cells.
New
Liu et al., In Leuk Lymphoma, 20 Nov 2014
Aside from alterations in apoptotic proteins and proteins associated with transcription and translation, our data also revealed changes in oxidative stress response and redox reaction-related proteins, such as Heat shock proteins (Hsps), DJ-1, Thioredoxin.
A role for the Parkinson's disease protein DJ-1 as a chaperone and antioxidant in the anhydrobiotic nematode Panagrolaimus superbus.
New
Burnell et al., Ireland. In Cell Stress Chaperones, 16 Nov 2014
UNLABELLED: Mutations in the human DJ-1/PARK7 gene are associated with familial Parkinson's disease.
Induction of DJ-1 protects neuronal cells from isoflurane induced neurotoxicity.
New
Zhou et al., Changsha, China. In Metab Brain Dis, 16 Nov 2014
DJ-1, a protein that is involved in the response to various kinds of stress, has shown its neuroprotective effects.
A new split-GFP based probe reveals DJ-1 translocation into the mitochondrial matrix to sustain ATP synthesis upon nutrient deprivation.
New
Brini et al., Padova, Italy. In Hum Mol Genet, 09 Nov 2014
UNLABELLED: The Parkinson's disease-related protein DJ-1 has a role in the protection against oxidative stress and maintenance of mitochondria structure.
Quantitative Proteomic Analysis of Global effect of LLL12 on U87 Cell's Proteome: An Insight into the Molecular Mechanism of LLL12.
New
Srivastava et al., Mumbai, India. In J Proteomics, 03 Nov 2014
Interestingly, triose phosphate isomerase (TPI), phosphoglycerate mutase 1 (PGAM1), adaptor molecule (CRK2), Protein DJ-1 (PARK7) and basic transcription factor 3 (BTF3) were found to be down-regulated and can be studied further to understand their therapeutic potential in gliomas.
Correlation between the biochemical pathways altered by mutated parkinson-related genes and chronic exposure to manganese.
Review
New
Roth, Buffalo, United States. In Neurotoxicology, 19 Sep 2014
These include the genes α-synuclein, parkin, PINK1, DJ-1, ATP13A2, and SLC30A10 which are associated with early-onset of Parkinson's as well as those genes linked with late onset of the disorder which include, LRRK2 and VPS35.
The role of DJ-1 in the oxidative stress cell death cascade after stroke.
Review
New
Kaneko et al., Tampa, United States. In Neural Regen Res, Sep 2014
Among many aberrant oxidative stress-associated proteins, DJ-1 has been associated with the oxidative stress cell death cascade primarily in Parkinson's disease.
Oxidized DJ-1 as a possible biomarker of Parkinson's disease.
Review
New
Saito, Kyoto, Japan. In J Clin Biochem Nutr, May 2014
DJ-1 is a causative gene of a familial form of Parkinson's disease, namely PARK7, and plays a significant role in antioxidative defense to protect the cells from oxidative stress.
The degeneration and replacement of dopamine cells in Parkinson's disease: the role of aging.
Review
New
Sabate et al., Santa Cruz de Tenerife, Spain. In Front Neuroanat, Dec 2013
Proteins involved in PD such as α-synuclein, UCH-L1, PINK1 or DJ-1, are also involved in aging.
Oxidative stress regulation by DJ-1 in the retinal pigment epithelium.
Review
New
Cai et al., Cleveland, United States. In Adv Exp Med Biol, Dec 2013
DJ-1 is a protein expressed in many tissues including the brain where it has been extensively studied due to its association with Parkinson's Disease (PD).
DJ-1 protein protects dopaminergic neurons against 6-OHDA/MG-132-induced neurotoxicity in rats.
GeneRIF
Pu et al., Beijing, China. In Brain Res Bull, 2012
DJ-1 protein protected dopaminergic neurons in two PD model rats by increasing antioxidant capacity and inhibiting alpha-synuclein expression.
Proteomic analysis reveals a protective role for DJ-1 during 6-hydroxydopamine-induced cell death.
GeneRIF
Oh et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2012
these data suggest that increases in pro-apoptotic proteins and decreases in anti-apoptotic proteins render DJ-1 knockdown cells more susceptible to oxidative stress.
Stimulation of vesicular monoamine transporter 2 activity by DJ-1 in SH-SY5Y cells.
GeneRIF
Iguchi-Ariga et al., Sapporo, Japan. In Biochem Biophys Res Commun, 2012
These results indicate that wild-type DJ-1, but not Parkinson's disease-derived mutant DJ-1, stimulates VMAT2 activity and that C106 is necessary for the stimulating activity of DJ-1 toward VMAT2.
Mechanism of BAG1 repair on Parkinson's disease-linked DJ1 mutation.
GeneRIF
Chen, Taiwan. In J Biomol Struct Dyn, 2011
Identification of potential BAG1-DJ1 mutant interaction interfaces.
Transcriptional activation of low-density lipoprotein receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasis.
GeneRIF
Ariga et al., Sapporo, Japan. In Plos One, 2011
DJ-1 participates in metabolism of fatty acid synthesis through transcriptional regulation of the LDLR gene
What genetics tells us about the causes and mechanisms of Parkinson's disease.
Review
Impact
Brice et al., Paris, France. In Physiol Rev, 2011
An impressive set of data in different model systems strongly suggest that mitochondrial dysfunction plays a central role in clinically similar, early-onset autosomal recessive PD forms caused by parkin and PINK1, and possibly DJ-1 gene mutations.
Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1.
Impact
GeneRIF
Surmeier et al., Chicago, United States. In Nature, 2011
Knocking out DJ-1 (associated with an early-onset form of Parkinson's disease) downregulated expression of two uncoupling proteins, compromised calcium-induced uncoupling and increased oxidation of matrix proteins specifically in SNc dopaminergic neurons
Expression of the Ciona intestinalis alternative oxidase (AOX) in Drosophila complements defects in mitochondrial oxidative phosphorylation.
Impact
Jacobs et al., Tampere, Finland. In Cell Metab, 2009
It also rescued the locomotor defect and excess mitochondrial ROS production of flies mutated in dj-1beta, a Drosophila homolog of the human Parkinson's disease gene DJ1.
Mitochondria in the aetiology and pathogenesis of Parkinson's disease.
Review
Impact
Schapira, London, United Kingdom. In Lancet Neurol, 2008
The proteins that are associated with familial PD--PTEN-induced putative kinase 1 (PINK1), DJ-1, alpha-synuclein, leucine-rich repeat kinase 2, and, possibly, parkin--are either mitochondrial proteins or are associated with mitochondria, and all interface with the pathways of oxidative stress and free radical damage.
Mitochondrial disease.
Review
Impact
Schapira, London, United Kingdom. In Lancet, 2006
Recently identified nuclear gene mutations of mitochondrial proteins include mutations of frataxin causing Friedreich's ataxia, PINK1, DJ1 causing Parkinson's disease and POLG causing infantile mtDNA depletion syndrome, ophthalmoplegia, parkinsonism, male subfertility and, in a transgenic mouse model, premature senescence.
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