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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 01 Apr 2015.

Parkinson protein 7

DJ-1, PARK7
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: E3 ubiquitin ligase, PINK1, CAN, LRRK2, alpha-Synuclein
Papers using DJ-1 antibodies
Initial Development and Validation of a Novel Extraction Method for Quantitative Mining of the Formalin-Fixed, Paraffin-Embedded Tissue Proteome for Biomarker Investigations
Supplier
Lucacchini Antonio et al., In Proteome Science, 2010
... Anti-CCT-5, anti-PARK7 and anti-BSPRY specific primary antibodies were from the Abnova Corporation (Taiwan) ...
In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro.
Supplier
Vanacker Jean-Marc, In PLoS ONE, 2006
... CA), actin, phospho-Akt, Akt and PTEN antibodies (Santa Cruz, CA), Caspase-9 antibody (Millipore, Billerica, MA), DJ-1 antibody (MBL International, Woburn, MA), HRP ...
Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1
Supplier
Chen Shengdi et al., In Molecular Neurodegeneration, 2004
... The following antibodies were used: DJ-1 Monoclonal Antibody (3E8) (Assay Designs, ADI-KAM-SA100-E), mono- and polyubiquitinylated conjugates, monoclonal Antibody (FK2) (Biomol, BML-PW8810R), DJ-1 polyclonal antibody ...
Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition
Supplier
Abeliovich Asa et al., In PLoS Biology, 2002
... Transfections with plasmids encoding human Flag-WT DJ-1, PD-associated L166P mutant DJ-1, or vector alone, were performed using Lipofectamine 2000 (Life Technologies) for 18–36 h according to ...
Papers on DJ-1
Functional dissection of a strong and specific microbe-associated molecular pattern-responsive synthetic promoter.
New
Hehl et al., Braunschweig, Germany. In Plant Biotechnol J, 27 Apr 2015
The 35-bp-long cis-sequence was identified in the promoter of the Arabidopsis thaliana DJ1E gene, a homologue of the human oncogene DJ1.
Evidence for a common biological pathway linking three Parkinson's disease-causing genes: parkin, PINK1 and DJ-1.
New
Bardien et al., Cape Town, South Africa. In Eur J Neurosci, 11 Apr 2015
Autosomal recessive, early-onset cases of PD are predominantly caused by mutations in the parkin, PINK1 and DJ-1 genes.
Doxorubicin induces apoptosis in Jurkat cells by mitochondria-dependent and mitochondria-independent mechanisms under normoxic and hypoxic conditions.
New
Jimenez-Del-Rio et al., Medellín, Colombia. In Anticancer Drugs, 02 Apr 2015
In addition, dxr (10 μmol/l) induced activation and/or nuclei translocation of NF-κB (6.6, 1.6-fold increase), p53 (4.3, 3.1 f), c-Jun (9.5, 5.0 f), apoptosis-inducing factor (AIF) (1.9, 3.9 f), caspase-3 (3.7, 1.9 f), overexpression of Parkin (2.1, 1.2 f)/PINK-1 (2.1 f) proteins, and reduced DJ-1 levels by half compared with untreated cells under normoxia, according to immunofluorescence and in-cell western analysis, respectively.
Mitochondrial homeostasis molecules: regulation by a trio of recessive Parkinson's disease genes.
Review
New
Son et al., Seoul, South Korea. In Exp Neurobiol, Dec 2014
In this mini-review, we provide an overview of the mitochondrial quality control mechanisms, emphasizing regulatory molecules in mitophagy and biogenesis that specifically interact with the protein products of three major recessive familial PD genes, PINK1, Parkin and DJ-1.
DJ-1 Knockout Augments Disease Severity and Shortens Survival in a Mouse Model of ALS.
New
Offen et al., Petah Tikva, Israel. In Plos One, Dec 2014
DJ-1 mutations, leading to the loss of functional protein, cause familial Parkinson's disease and motor neuron disease in several patients.
Life-time expression of the proteins peroxiredoxin, beta-synuclein, PARK7/DJ-1, and stathmin in the primary visual and primary somatosensory cortices in rats.
New
Thanos et al., Münster, Germany. In Front Neuroanat, Dec 2014
Four distinct proteins are regulated in the aging neuroretina and may be regulated in the cerebral cortex, too: peroxiredoxin, beta-synuclein, PARK[Parkinson disease(autosomal recessive, early onset)]7/DJ-1, and Stathmin.
The role of DJ-1 in the oxidative stress cell death cascade after stroke.
Review
New
Kaneko et al., Tampa, United States. In Neural Regen Res, Sep 2014
Among many aberrant oxidative stress-associated proteins, DJ-1 has been associated with the oxidative stress cell death cascade primarily in Parkinson's disease.
Oxidized DJ-1 as a possible biomarker of Parkinson's disease.
Review
New
Saito, Kyoto, Japan. In J Clin Biochem Nutr, May 2014
DJ-1 is a causative gene of a familial form of Parkinson's disease, namely PARK7, and plays a significant role in antioxidative defense to protect the cells from oxidative stress.
The degeneration and replacement of dopamine cells in Parkinson's disease: the role of aging.
Review
Sabate et al., Santa Cruz de Tenerife, Spain. In Front Neuroanat, 2013
Proteins involved in PD such as α-synuclein, UCH-L1, PINK1 or DJ-1, are also involved in aging.
Cross Talk between Two Antioxidant Systems, Thioredoxin and DJ-1: Consequences for Cancer.
Review
Tonissen et al., Griffith, Australia. In Oncoscience, 2013
In response to increased ROS levels, cellular antioxidant molecules such as thioredoxin, peroxiredoxins, glutaredoxins, DJ-1, and superoxide dismutases are upregulated to counteract the detrimental effect of ROS.
DJ-1 protein protects dopaminergic neurons against 6-OHDA/MG-132-induced neurotoxicity in rats.
GeneRIF
Pu et al., Beijing, China. In Brain Res Bull, 2012
DJ-1 protein protected dopaminergic neurons in two PD model rats by increasing antioxidant capacity and inhibiting alpha-synuclein expression.
Proteomic analysis reveals a protective role for DJ-1 during 6-hydroxydopamine-induced cell death.
GeneRIF
Oh et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2012
these data suggest that increases in pro-apoptotic proteins and decreases in anti-apoptotic proteins render DJ-1 knockdown cells more susceptible to oxidative stress.
Stimulation of vesicular monoamine transporter 2 activity by DJ-1 in SH-SY5Y cells.
GeneRIF
Iguchi-Ariga et al., Sapporo, Japan. In Biochem Biophys Res Commun, 2012
These results indicate that wild-type DJ-1, but not Parkinson's disease-derived mutant DJ-1, stimulates VMAT2 activity and that C106 is necessary for the stimulating activity of DJ-1 toward VMAT2.
Mechanism of BAG1 repair on Parkinson's disease-linked DJ1 mutation.
GeneRIF
Chen, Taiwan. In J Biomol Struct Dyn, 2011
Identification of potential BAG1-DJ1 mutant interaction interfaces.
Transcriptional activation of low-density lipoprotein receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasis.
GeneRIF
Ariga et al., Sapporo, Japan. In Plos One, 2011
DJ-1 participates in metabolism of fatty acid synthesis through transcriptional regulation of the LDLR gene
What genetics tells us about the causes and mechanisms of Parkinson's disease.
Review
Impact
Brice et al., Paris, France. In Physiol Rev, 2011
An impressive set of data in different model systems strongly suggest that mitochondrial dysfunction plays a central role in clinically similar, early-onset autosomal recessive PD forms caused by parkin and PINK1, and possibly DJ-1 gene mutations.
Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1.
Impact
GeneRIF
Surmeier et al., Chicago, United States. In Nature, 2011
Knocking out DJ-1 (associated with an early-onset form of Parkinson's disease) downregulated expression of two uncoupling proteins, compromised calcium-induced uncoupling and increased oxidation of matrix proteins specifically in SNc dopaminergic neurons
Expression of the Ciona intestinalis alternative oxidase (AOX) in Drosophila complements defects in mitochondrial oxidative phosphorylation.
Impact
Jacobs et al., Tampere, Finland. In Cell Metab, 2009
It also rescued the locomotor defect and excess mitochondrial ROS production of flies mutated in dj-1beta, a Drosophila homolog of the human Parkinson's disease gene DJ1.
Mitochondria in the aetiology and pathogenesis of Parkinson's disease.
Review
Impact
Schapira, London, United Kingdom. In Lancet Neurol, 2008
The proteins that are associated with familial PD--PTEN-induced putative kinase 1 (PINK1), DJ-1, alpha-synuclein, leucine-rich repeat kinase 2, and, possibly, parkin--are either mitochondrial proteins or are associated with mitochondria, and all interface with the pathways of oxidative stress and free radical damage.
Mitochondrial disease.
Review
Impact
Schapira, London, United Kingdom. In Lancet, 2006
Recently identified nuclear gene mutations of mitochondrial proteins include mutations of frataxin causing Friedreich's ataxia, PINK1, DJ1 causing Parkinson's disease and POLG causing infantile mtDNA depletion syndrome, ophthalmoplegia, parkinsonism, male subfertility and, in a transgenic mouse model, premature senescence.
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