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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Nov 2014.

Parkinson protein 7

DJ-1, PARK7
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: E3 ubiquitin ligase, PINK1, CAN, LRRK2, alpha-Synuclein
Papers using DJ-1 antibodies
Initial Development and Validation of a Novel Extraction Method for Quantitative Mining of the Formalin-Fixed, Paraffin-Embedded Tissue Proteome for Biomarker Investigations
Supplier
Lucacchini Antonio et al., In Proteome Science, 2010
... Anti-CCT-5, anti-PARK7 and anti-BSPRY specific primary antibodies were from the Abnova Corporation (Taiwan) ...
In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro.
Supplier
Vanacker Jean-Marc, In PLoS ONE, 2006
... CA), actin, phospho-Akt, Akt and PTEN antibodies (Santa Cruz, CA), Caspase-9 antibody (Millipore, Billerica, MA), DJ-1 antibody (MBL International, Woburn, MA), HRP ...
Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1
Supplier
Chen Shengdi et al., In Molecular Neurodegeneration, 2004
... The following antibodies were used: DJ-1 Monoclonal Antibody (3E8) (Assay Designs, ADI-KAM-SA100-E), mono- and polyubiquitinylated conjugates, monoclonal Antibody (FK2) (Biomol, BML-PW8810R), DJ-1 polyclonal antibody ...
Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition
Supplier
Abeliovich Asa et al., In PLoS Biology, 2002
... Transfections with plasmids encoding human Flag-WT DJ-1, PD-associated L166P mutant DJ-1, or vector alone, were performed using Lipofectamine 2000 (Life Technologies) for 18–36 h according to ...
Papers on DJ-1
Parkinsonism-associated protein DJ-1/Park7 is a major protein deglycase that repairs methylglyoxal- and glyoxal-glycated cysteine, arginine and lysine residues.
New
Lamouri et al., France. In J Biol Chem, 21 Dec 2014
DJ-1 was reported to be a multifunctional oxidative stress response protein with poorly defined function.
Neural stem cells in Parkinson's disease: a role for neurogenesis defects in onset and progression.
New
Schwamborn et al., Esch-sur-Alzette, Luxembourg. In Cell Mol Life Sci, 18 Dec 2014
Finally, the roles of PD-related genes, SNCA, LRRK2, VPS35, Parkin, PINK1 and DJ-1 have been studied in NSCs, progenitor cells and induced pluripotent stem cells, demonstrating a role for some of these genes in stem/progenitor cell proliferation and maintenance.
ATF3 Protects Pulmonary Resident Cells from Acute Lung Injury by Preventing Keap-1-mediated Nrf2 Degradation in a DJ-1-dependent manner.
New
Dos Santos et al., Toronto, Canada. In Antioxid Redox Signal, 17 Dec 2014
Innovation: In our model, in the absence of ATF3 in parenchymal cells increased Nrf2 degradation is the result of increased Keap-1 expression and loss of DJ-1 (Parkinson disease [autosomal recessive, early onset] 7), previously not known to play a role in lung injury.
DJ-1 knockdown inhibits growth and xenograft‑induced tumor generation of human hepatocellular carcinoma cells.
New
Qiu et al., Wuhan, China. In Oncol Rep, 07 Dec 2014
UNLABELLED: The aim of this study was to identify potential downstream effectors of the oncogene DJ-1 in hepatocellular carcinoma (HCC) cell lines, and examine its role in the Akt signaling pathway and HCC oncogenesis.
S-allyl cysteine ameliorates the quality of sperm and provides protection from age-related sperm dysfunction and oxidative stress in rats.
New
Minamiyama et al., Ōsaka, Japan. In J Clin Biochem Nutr, 30 Nov 2014
It has been reported that the total protein of DJ-1 was decreased in a proteomic analysis of seminal plasma from asthenozoospermia patients and a DJ-1 protein acts as a sensor of cellular redox homeostasis.
The role of DJ-1 in the oxidative stress cell death cascade after stroke.
Review
New
Kaneko et al., Tampa, United States. In Neural Regen Res, Sep 2014
Among many aberrant oxidative stress-associated proteins, DJ-1 has been associated with the oxidative stress cell death cascade primarily in Parkinson's disease.
Protective and toxic roles of dopamine in Parkinson's disease.
Review
New
Zucca et al., Santiago, Chile. In J Neurochem, Jun 2014
The discovery of genes associated with Parkinson's disease (such as alpha synuclein (SNCA), E3 ubiquitin protein ligase (parkin), DJ-1 (PARK7), ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL-1), serine/threonine-protein kinase (PINK-1), leucine-rich repeat kinase 2 (LRRK2), cation-transporting ATPase 13A1 (ATP13A), etc.) contributed enormously to basic research towards understanding the role of these proteins in the sporadic form of the disease.
Oxidized DJ-1 as a possible biomarker of Parkinson's disease.
Review
New
Saito, Kyoto, Japan. In J Clin Biochem Nutr, May 2014
DJ-1 is a causative gene of a familial form of Parkinson's disease, namely PARK7, and plays a significant role in antioxidative defense to protect the cells from oxidative stress.
The degeneration and replacement of dopamine cells in Parkinson's disease: the role of aging.
Review
New
Sabate et al., Santa Cruz de Tenerife, Spain. In Front Neuroanat, Dec 2013
Proteins involved in PD such as α-synuclein, UCH-L1, PINK1 or DJ-1, are also involved in aging.
Oxidative stress regulation by DJ-1 in the retinal pigment epithelium.
Review
New
Cai et al., Cleveland, United States. In Adv Exp Med Biol, Dec 2013
DJ-1 is a protein expressed in many tissues including the brain where it has been extensively studied due to its association with Parkinson's Disease (PD).
DJ-1 protein protects dopaminergic neurons against 6-OHDA/MG-132-induced neurotoxicity in rats.
GeneRIF
Pu et al., Beijing, China. In Brain Res Bull, 2012
DJ-1 protein protected dopaminergic neurons in two PD model rats by increasing antioxidant capacity and inhibiting alpha-synuclein expression.
Proteomic analysis reveals a protective role for DJ-1 during 6-hydroxydopamine-induced cell death.
GeneRIF
Oh et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2012
these data suggest that increases in pro-apoptotic proteins and decreases in anti-apoptotic proteins render DJ-1 knockdown cells more susceptible to oxidative stress.
Stimulation of vesicular monoamine transporter 2 activity by DJ-1 in SH-SY5Y cells.
GeneRIF
Iguchi-Ariga et al., Sapporo, Japan. In Biochem Biophys Res Commun, 2012
These results indicate that wild-type DJ-1, but not Parkinson's disease-derived mutant DJ-1, stimulates VMAT2 activity and that C106 is necessary for the stimulating activity of DJ-1 toward VMAT2.
Mechanism of BAG1 repair on Parkinson's disease-linked DJ1 mutation.
GeneRIF
Chen, Taiwan. In J Biomol Struct Dyn, 2011
Identification of potential BAG1-DJ1 mutant interaction interfaces.
Transcriptional activation of low-density lipoprotein receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasis.
GeneRIF
Ariga et al., Sapporo, Japan. In Plos One, 2011
DJ-1 participates in metabolism of fatty acid synthesis through transcriptional regulation of the LDLR gene
What genetics tells us about the causes and mechanisms of Parkinson's disease.
Review
Impact
Brice et al., Paris, France. In Physiol Rev, 2011
An impressive set of data in different model systems strongly suggest that mitochondrial dysfunction plays a central role in clinically similar, early-onset autosomal recessive PD forms caused by parkin and PINK1, and possibly DJ-1 gene mutations.
Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1.
Impact
GeneRIF
Surmeier et al., Chicago, United States. In Nature, 2011
Knocking out DJ-1 (associated with an early-onset form of Parkinson's disease) downregulated expression of two uncoupling proteins, compromised calcium-induced uncoupling and increased oxidation of matrix proteins specifically in SNc dopaminergic neurons
Expression of the Ciona intestinalis alternative oxidase (AOX) in Drosophila complements defects in mitochondrial oxidative phosphorylation.
Impact
Jacobs et al., Tampere, Finland. In Cell Metab, 2009
It also rescued the locomotor defect and excess mitochondrial ROS production of flies mutated in dj-1beta, a Drosophila homolog of the human Parkinson's disease gene DJ1.
Mitochondria in the aetiology and pathogenesis of Parkinson's disease.
Review
Impact
Schapira, London, United Kingdom. In Lancet Neurol, 2008
The proteins that are associated with familial PD--PTEN-induced putative kinase 1 (PINK1), DJ-1, alpha-synuclein, leucine-rich repeat kinase 2, and, possibly, parkin--are either mitochondrial proteins or are associated with mitochondria, and all interface with the pathways of oxidative stress and free radical damage.
Mitochondrial disease.
Review
Impact
Schapira, London, United Kingdom. In Lancet, 2006
Recently identified nuclear gene mutations of mitochondrial proteins include mutations of frataxin causing Friedreich's ataxia, PINK1, DJ1 causing Parkinson's disease and POLG causing infantile mtDNA depletion syndrome, ophthalmoplegia, parkinsonism, male subfertility and, in a transgenic mouse model, premature senescence.
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