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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Nov 2015.

Parkinson protein 7

The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: E3 ubiquitin ligase, PINK1, CAN, LRRK2, AGE
Papers using DJ-1 antibodies
Initial Development and Validation of a Novel Extraction Method for Quantitative Mining of the Formalin-Fixed, Paraffin-Embedded Tissue Proteome for Biomarker Investigations
Lucacchini Antonio et al., In Proteome Science, 2010
... Anti-CCT-5, anti-PARK7 and anti-BSPRY specific primary antibodies were from the Abnova Corporation (Taiwan) ...
In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro.
Vanacker Jean-Marc, In PLoS ONE, 2006
... CA), actin, phospho-Akt, Akt and PTEN antibodies (Santa Cruz, CA), Caspase-9 antibody (Millipore, Billerica, MA), DJ-1 antibody (MBL International, Woburn, MA), HRP ...
Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1
Chen Shengdi et al., In Molecular Neurodegeneration, 2004
... The following antibodies were used: DJ-1 Monoclonal Antibody (3E8) (Assay Designs, ADI-KAM-SA100-E), mono- and polyubiquitinylated conjugates, monoclonal Antibody (FK2) (Biomol, BML-PW8810R), DJ-1 polyclonal antibody ...
Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition
Abeliovich Asa et al., In PLoS Biology, 2002
... Transfections with plasmids encoding human Flag-WT DJ-1, PD-associated L166P mutant DJ-1, or vector alone, were performed using Lipofectamine 2000 (Life Technologies) for 18–36 h according to ...
Papers on DJ-1
Changes in the expression of neurotransmitter receptors in Parkin and DJ-1 knockout mice - A quantitative multireceptor study.
Zilles et al., Jülich, Germany. In Neuroscience, 03 Dec 2015
Parkin and DJ-1, were found in human hereditary PD with early onset.
Effect of Prolonged Simulated Microgravity on Metabolic Proteins in Rat Hippocampus: Steps Toward Safe Space Travel.
Deng et al., In J Proteome Res, 02 Dec 2015
Moreover, DJ-1 and peroxiredoxin 6, which defend against oxidative damage, were up-regulated in the hippocampus.
The protective role of DJ-1 in ultraviolet-induced damage of human skin: DJ-1 levels in the stratum corneum as an indicator of antioxidative defense.
Matsukuma et al., Yokohama, Japan. In Arch Dermatol Res, 26 Nov 2015
UNASSIGNED: DJ-1 is a multifunctional protein associated with Parkinson's disease and plays a significant role in protecting nerve cells from oxidative stress.
Parkinson's disease proteins: Novel mitochondrial targets for cardioprotection.
Hausenloy et al., London, United Kingdom. In Pharmacol Ther, 16 Nov 2015
In dopaminergic neurons of the substantial nigra, these PD proteins, which include Parkin, PINK1, DJ-1, LRRK2, and α-synuclein, play essential roles in preventing cell death - through maintaining normal mitochondrial function, protecting against oxidative stress, mediating mitophagy, and preventing apoptosis.
Analysis of the genetic variability in Parkinson's disease from Southern Spain.
Pittman et al., Granada, Spain. In Neurobiol Aging, 08 Nov 2015
Genetic analysis was performed through a next-generation sequencing panel to screen 8 PD-related genes (LRRK2, SNCA, PARKIN, PINK1, DJ-1, VPS35, GBA, and GCH1) in EOPD and FPD groups and direct Sanger sequencing of GBA exons 8-11 and LRRK2 exons 31 and 41 in the LOPD group.
Activation of endogenous antioxidants as a common therapeutic strategy against cancer, neurodegeneration and cardiovascular diseases: A lesson learnt from DJ-1.
Chan et al., Kao-hsiung, Taiwan. In Pharmacol Ther, 29 Oct 2015
Using as our illustrative example is DJ-1, a homodimeric protein that is ubiquitously expressed in a variety of mammalian tissues, including the brain, and is found in the matrix and the intermembrane space of the mitochondria.
Animal models of Parkinson's disease: An updated overview.
Kachidian et al., Marseille, France. In Rev Neurol (paris), 03 Oct 2015
"Classic" models are based on neurotoxins that selectively target catecholaminergic neurons (such as 6-hydroxydopamine, 1-methyl-1,2,3,6-tetrahydropiridine, agricultural pesticides, etc.), while more recent models employ genetic manipulations that either introduce mutations similar to those find in familial cases of PD (α-synuclein, DJ-1, PINK1, Parkin, etc.) or selectively disrupt nigrostriatal neurons (MitoPark, Pitx3, Nurr1, etc.).
Fluid biomarkers in multiple system atrophy: A review of the MSA Biomarker Initiative.
Meissner et al., Bordeaux, France. In Neurobiol Dis, Aug 2015
Currently, the clinically most useful markers may comprise a combination of the light chain of neurofilament (which is consistently elevated in MSA compared to controls and Parkinson's disease), metabolites of the catecholamine pathway and proteins such as α-synuclein, DJ-1 and total-tau.
Evidence for a common biological pathway linking three Parkinson's disease-causing genes: parkin, PINK1 and DJ-1.
Bardien et al., Cape Town, South Africa. In Eur J Neurosci, May 2015
Autosomal recessive, early-onset cases of PD are predominantly caused by mutations in the parkin, PINK1 and DJ-1 genes.
The Clinical Relevance of Serum NDKA, NMDA, PARK7, and UFDP Levels with Phlegm-Heat Syndrome and Treatment Efficacy Evaluation of Traditional Chinese Medicine in Acute Ischemic Stroke.
Wang et al., Beijing, China. In Evid Based Complement Alternat Med, Dec 2014
According to the methods of Patient-Reported Outcome (PRO) based on the patient reports internationally and referring to U.S. Food and Drug Administration (FDA) guide, some scholars developed this PRO of stroke which is consistent with China's national conditions, and using it the feel of stroke patients was introduced into the clinical efficacy evaluation system of stoke.
DJ-1 protein protects dopaminergic neurons against 6-OHDA/MG-132-induced neurotoxicity in rats.
Pu et al., Beijing, China. In Brain Res Bull, 2012
DJ-1 protein protected dopaminergic neurons in two PD model rats by increasing antioxidant capacity and inhibiting alpha-synuclein expression.
Proteomic analysis reveals a protective role for DJ-1 during 6-hydroxydopamine-induced cell death.
Oh et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2012
these data suggest that increases in pro-apoptotic proteins and decreases in anti-apoptotic proteins render DJ-1 knockdown cells more susceptible to oxidative stress.
Stimulation of vesicular monoamine transporter 2 activity by DJ-1 in SH-SY5Y cells.
Iguchi-Ariga et al., Sapporo, Japan. In Biochem Biophys Res Commun, 2012
These results indicate that wild-type DJ-1, but not Parkinson's disease-derived mutant DJ-1, stimulates VMAT2 activity and that C106 is necessary for the stimulating activity of DJ-1 toward VMAT2.
Mechanism of BAG1 repair on Parkinson's disease-linked DJ1 mutation.
Chen, Taiwan. In J Biomol Struct Dyn, 2011
Identification of potential BAG1-DJ1 mutant interaction interfaces.
Transcriptional activation of low-density lipoprotein receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasis.
Ariga et al., Sapporo, Japan. In Plos One, 2011
DJ-1 participates in metabolism of fatty acid synthesis through transcriptional regulation of the LDLR gene
What genetics tells us about the causes and mechanisms of Parkinson's disease.
Brice et al., Paris, France. In Physiol Rev, 2011
An impressive set of data in different model systems strongly suggest that mitochondrial dysfunction plays a central role in clinically similar, early-onset autosomal recessive PD forms caused by parkin and PINK1, and possibly DJ-1 gene mutations.
Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1.
Surmeier et al., Chicago, United States. In Nature, 2011
Knocking out DJ-1 (associated with an early-onset form of Parkinson's disease) downregulated expression of two uncoupling proteins, compromised calcium-induced uncoupling and increased oxidation of matrix proteins specifically in SNc dopaminergic neurons
Expression of the Ciona intestinalis alternative oxidase (AOX) in Drosophila complements defects in mitochondrial oxidative phosphorylation.
Jacobs et al., Tampere, Finland. In Cell Metab, 2009
It also rescued the locomotor defect and excess mitochondrial ROS production of flies mutated in dj-1beta, a Drosophila homolog of the human Parkinson's disease gene DJ1.
Mitochondria in the aetiology and pathogenesis of Parkinson's disease.
Schapira, London, United Kingdom. In Lancet Neurol, 2008
The proteins that are associated with familial PD--PTEN-induced putative kinase 1 (PINK1), DJ-1, alpha-synuclein, leucine-rich repeat kinase 2, and, possibly, parkin--are either mitochondrial proteins or are associated with mitochondria, and all interface with the pathways of oxidative stress and free radical damage.
Mitochondrial disease.
Schapira, London, United Kingdom. In Lancet, 2006
Recently identified nuclear gene mutations of mitochondrial proteins include mutations of frataxin causing Friedreich's ataxia, PINK1, DJ1 causing Parkinson's disease and POLG causing infantile mtDNA depletion syndrome, ophthalmoplegia, parkinsonism, male subfertility and, in a transgenic mouse model, premature senescence.
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