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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 02 Oct 2014.

Parkinson protein 7

DJ-1, PARK7
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: E3 ubiquitin ligase, PINK1, CAN, LRRK2, alpha-Synuclein
Papers using DJ-1 antibodies
Initial Development and Validation of a Novel Extraction Method for Quantitative Mining of the Formalin-Fixed, Paraffin-Embedded Tissue Proteome for Biomarker Investigations
Supplier
Lucacchini Antonio et al., In Proteome Science, 2010
... Anti-CCT-5, anti-PARK7 and anti-BSPRY specific primary antibodies were from the Abnova Corporation (Taiwan) ...
In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro.
Supplier
Vanacker Jean-Marc, In PLoS ONE, 2006
... CA), actin, phospho-Akt, Akt and PTEN antibodies (Santa Cruz, CA), Caspase-9 antibody (Millipore, Billerica, MA), DJ-1 antibody (MBL International, Woburn, MA), HRP ...
Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1
Supplier
Chen Shengdi et al., In Molecular Neurodegeneration, 2004
... The following antibodies were used: DJ-1 Monoclonal Antibody (3E8) (Assay Designs, ADI-KAM-SA100-E), mono- and polyubiquitinylated conjugates, monoclonal Antibody (FK2) (Biomol, BML-PW8810R), DJ-1 polyclonal antibody ...
Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition
Supplier
Abeliovich Asa et al., In PLoS Biology, 2002
... Transfections with plasmids encoding human Flag-WT DJ-1, PD-associated L166P mutant DJ-1, or vector alone, were performed using Lipofectamine 2000 (Life Technologies) for 18–36 h according to ...
Papers on DJ-1
High-fat diet induced isoform changes of the Parkinson's disease protein DJ-1.
New
Stühler et al., Düsseldorf, Germany. In J Proteome Res, Jun 2014
One isoform of the protein DJ-1 was elevated in the high-fat diet group in three different mouse strains SWR/J, C57BL/6N, and AKR/J analyzed.
Are force asymmetries measured in jump tests associated with previous injury in professional footballers?
New
Lewin et al., London, United Kingdom. In Br J Sports Med, Apr 2014
RESULTS: Compared to N-INJ, P-INJ mean asymmetry in P-INJ was CMJ takeoff force was 8% higher (CMT-a), in landing force (CML-a) 57% higher, in DJ first landing (DJ1-a) and second landing (DJ2-a) 11% and 31% higher, respectively.
Genetic mutations in early-onset Parkinson's disease Mexican patients: molecular testing implications.
New
López-López et al., Chiconcuac, Mexico. In Am J Med Genet B Neuropsychiatr Genet, Apr 2014
Mutations in PARK2, PINK1, and DJ-1 have been associated with autosomal recessive early-onset Parkinson's disease.
Park7 expression influences myotube size and myosin expression in muscle.
New
Bidwell et al., West Lafayette, United States. In Plos One, Dec 2013
The up-regulation of PARK7 was identified in hypertrophied muscles by microarray analysis and further validated by quantitative PCR.
Oxidative stress regulation by DJ-1 in the retinal pigment epithelium.
New
Cai et al., Cleveland, United States. In Adv Exp Med Biol, Dec 2013
DJ-1 is a protein expressed in many tissues including the brain where it has been extensively studied due to its association with Parkinson's Disease (PD).
Biomarkers in Parkinson's disease (recent update).
Review
New
Ebadi et al., Netherlands. In Neurochem Int, Sep 2013
Promising biomarkers include: fluid biomarkers, neuromelanin antibodies, pathological forms of α-Syn, DJ-1, amyloid β and tau in the CSF, patterns of gene expression, metabolomics, urate, as well as protein profiling in the blood and CSF samples.
Monogenic Parkinson's disease and parkinsonism: clinical phenotypes and frequencies of known mutations.
Review
New
Puschmann, Lund, Sweden. In Parkinsonism Relat Disord, Apr 2013
Mutations in seven genes are robustly associated with autosomal dominant (SNCA, LRRK2, EIF4G1, VPS35) or recessive (parkin/PARK2, PINK1, DJ1/PARK7) Parkinson's disease (PD) or parkinsonism.
Renal dopamine receptors, oxidative stress, and hypertension.
Review
Armando et al., Baltimore, United States. In Int J Mol Sci, 2012
Thus, stimulation of the D2R increases the expression of endogenous anti-oxidants, such as Parkinson protein 7 (PARK7 or DJ-1), paraoxonase 2 (PON2), and heme oxygenase 2 (HO-2), all of which can inhibit NADPH oxidase activity.
SOD1 and DJ-1 converge at Nrf2 pathway: a clue for antioxidant therapeutic potential in neurodegeneration.
Review
Cereda et al., Pavia, Italy. In Oxid Med Cell Longev, 2012
Subsequently, we focus on DJ-1 and SOD1 proteins, which are involved in PD and ALS and also exert a prominent role in the interaction between redox homeostasis and neurodegeneration.
DJ-1 protein protects dopaminergic neurons against 6-OHDA/MG-132-induced neurotoxicity in rats.
GeneRIF
Pu et al., Beijing, China. In Brain Res Bull, 2012
DJ-1 protein protected dopaminergic neurons in two PD model rats by increasing antioxidant capacity and inhibiting alpha-synuclein expression.
Proteomic analysis reveals a protective role for DJ-1 during 6-hydroxydopamine-induced cell death.
GeneRIF
Oh et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2012
these data suggest that increases in pro-apoptotic proteins and decreases in anti-apoptotic proteins render DJ-1 knockdown cells more susceptible to oxidative stress.
Stimulation of vesicular monoamine transporter 2 activity by DJ-1 in SH-SY5Y cells.
GeneRIF
Iguchi-Ariga et al., Sapporo, Japan. In Biochem Biophys Res Commun, 2012
These results indicate that wild-type DJ-1, but not Parkinson's disease-derived mutant DJ-1, stimulates VMAT2 activity and that C106 is necessary for the stimulating activity of DJ-1 toward VMAT2.
Matrix metalloproteinases, new insights into the understanding of neurodegenerative disorders.
Review
Joh et al., Orlando, United States. In Biomol Ther (seoul), 2012
Among them, MMP-3 appears to be involved in a range of pathogenesis processes in PD including neuroinflammation, apoptosis and degradation of α-synuclein and DJ-1.
Mechanism of BAG1 repair on Parkinson's disease-linked DJ1 mutation.
GeneRIF
Chen, Taiwan. In J Biomol Struct Dyn, 2011
Identification of potential BAG1-DJ1 mutant interaction interfaces.
Transcriptional activation of low-density lipoprotein receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasis.
GeneRIF
Ariga et al., Sapporo, Japan. In Plos One, 2011
DJ-1 participates in metabolism of fatty acid synthesis through transcriptional regulation of the LDLR gene
What genetics tells us about the causes and mechanisms of Parkinson's disease.
Review
Impact
Brice et al., Paris, France. In Physiol Rev, 2011
An impressive set of data in different model systems strongly suggest that mitochondrial dysfunction plays a central role in clinically similar, early-onset autosomal recessive PD forms caused by parkin and PINK1, and possibly DJ-1 gene mutations.
Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1.
Impact
GeneRIF
Surmeier et al., Chicago, United States. In Nature, 2011
Knocking out DJ-1 (associated with an early-onset form of Parkinson's disease) downregulated expression of two uncoupling proteins, compromised calcium-induced uncoupling and increased oxidation of matrix proteins specifically in SNc dopaminergic neurons
Expression of the Ciona intestinalis alternative oxidase (AOX) in Drosophila complements defects in mitochondrial oxidative phosphorylation.
Impact
Jacobs et al., Tampere, Finland. In Cell Metab, 2009
It also rescued the locomotor defect and excess mitochondrial ROS production of flies mutated in dj-1beta, a Drosophila homolog of the human Parkinson's disease gene DJ1.
Mitochondria in the aetiology and pathogenesis of Parkinson's disease.
Review
Impact
Schapira, London, United Kingdom. In Lancet Neurol, 2008
The proteins that are associated with familial PD--PTEN-induced putative kinase 1 (PINK1), DJ-1, alpha-synuclein, leucine-rich repeat kinase 2, and, possibly, parkin--are either mitochondrial proteins or are associated with mitochondria, and all interface with the pathways of oxidative stress and free radical damage.
Mitochondrial disease.
Review
Impact
Schapira, London, United Kingdom. In Lancet, 2006
Recently identified nuclear gene mutations of mitochondrial proteins include mutations of frataxin causing Friedreich's ataxia, PINK1, DJ1 causing Parkinson's disease and POLG causing infantile mtDNA depletion syndrome, ophthalmoplegia, parkinsonism, male subfertility and, in a transgenic mouse model, premature senescence.
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