Thioredoxin superfamily and its effects on cardiac physiology and pathology.
Cambridge, United States. In Compr Physiol, Apr 2015
While thioredoxin and glutaredoxin primarily act as antioxidants by reducing protein disulfides and mixed disulfide, another member of the superfamily, protein disulfide isomerase (PDI), can act as an oxidant by forming intrachain disulfide bonds that contribute to proper protein folding.
The complex route to MHC class I-peptide complexes.
Southampton, United Kingdom. In Cell, 2006
In this issue of Cell, Park et al. (2006) show that peptide loading gets a helping hand from a resident ER enzyme called protein disulfide isomerase, a chaperone that has oxidoreductase activity.