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Dispatched homolog 1

DISP1, ICB, mDispA, Dispatched 1
The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Iris, CAN, HAD, Shh, V1a
Papers on DISP1
Whole-genome association analysis of treatment response in obsessive-compulsive disorder.
Shugart et al., Bethesda, United States. In Mol Psychiatry, Feb 2016
The top single-nucleotide polymorphism (SNP) was rs17162912 (P=1.76 × 10(-8)), which is near the DISP1 gene on 1q41-q42, a microdeletion region implicated in neurological development.
Complex mode of inheritance in holoprosencephaly revealed by whole exome sequencing.
David et al., Rennes, France. In Clin Genet, Feb 2016
In the first family presenting two fetuses with alobar and semi-lobar HPE, we found mutations in two genes involved in HPE, SHH and DISP1, inherited respectively from the father and the mother.
The business impact of an integrated continuous biomanufacturing platform for recombinant protein production.
Konstantinov et al., Framingham, United States. In J Biotechnol, Dec 2015
In this manuscript, we use process economic modeling and Monte Carlo simulations to evaluate an integrated continuous biomanufacturing (ICB) platform and conduct risk-based valuation to generate a probabilistic range of net-present values (NPVs).
A Cholesterol-Dependent Endocytic Mechanism Generates Midbody Tubules During Cytokinesis.
Chircop et al., Sydney, Australia. In Traffic, Nov 2015
Vesicles derived from internal membrane stores, such as the Golgi, lysosomes, and early and recycling endosomes accumulate at the intracellular bridge (ICB) during cytokinesis.
Auto-immune arthropathy and uveitis as complications from PD-1 inhibitor.
Choueiri et al., Boston, United States. In Arthritis Rheumatol, Sep 2015
UNASSIGNED: The decision by the Food and Drug Administration (FDA) to approve several immune checkpoints blockers (ICB) is aligned with the growing evidence that these novel agents will play a central role in many cancer types.
Reconstructing gene regulatory dynamics from high-dimensional single-cell snapshot data.
Theis et al., Garching bei München, Germany. In Bioinformatics, Jul 2015
AVAILABILITY AND IMPLEMENTATION: C++ and Matlab code available at
Proteomic profiling of the retinas in a neonatal rat model of oxygen-induced retinopathy with a reproducible ion-current-based MS1 approach.
Qu et al., Buffalo, United States. In J Proteome Res, Jun 2015
Here we employed a reproducible ion-current-based MS1 quantification approach (ICB) to explore the retinal proteomic changes in early stage of ROP in a rat model of oxygen-induced retinopathy (OIR).
DRD and GRIN2B polymorphisms and their association with the development of impulse control behaviour among Malaysian Parkinson's disease patients.
Mohamed Ibrahim et al., Kuala Selangor, Malaysia. In Bmc Neurol, 2014
BACKGROUND: Impulse control disorder (ICD) and behaviours (ICB) represent a group of behavioural disorders that have become increasingly recognised in Parkinson's disease (PD) patients who previously used dopaminergic medications, particularly dopamine agonists and levodopa.
Topical administration of diminazene aceturate decreases inflammation in endotoxin-induced uveitis.
Lei et al., Chongqing, China. In Mol Vis, 2014
CD11b-positive cells adjacent to the iris ciliary body (ICB) were stained by immunohistochemistry.
[Post-transcriptional regulation of dual-specificity phosphatase-1 by RNA-binding protein HuR T118 in heat shock].
Jiang et al., Guangzhou, China. In Nan Fang Yi Ke Da Xue Xue Bao, 2014
Over-expression of HuR(T118A) down-regulated DUSP1 mRNA and protein expressions in cells challenged with heat shock, while HuR(T118E) over-expression significantly increased DISP1 expression at both mRNA and protein levels.
Chitosan oligosaccharides attenuate ocular inflammation in rats with experimental autoimmune anterior uveitis.
Yang et al., Taipei, Taiwan. In Mediators Inflamm, 2013
The effects of COS were evaluated by determining the clinical scores and the morphology of the iris/ciliary body (ICB).
FIP3-endosome-dependent formation of the secondary ingression mediates ESCRT-III recruitment during cytokinesis.
Prekeris et al., Aurora, United States. In Nat Cell Biol, 2012
The final cytokinesis event involves severing of the connecting intercellular bridge (ICB) between daughter cells.
New cases and refinement of the critical region in the 1q41q42 microdeletion syndrome.
Shaffer et al., Spokane, United States. In Eur J Med Genet, 2011
Studies indicate that DISP1 haploinsufficiency may not be solely responsible for the major features of 1q41q42 microdeletion syndrome, and other genes in the SRO likely play a role in the phenotype.
Characterization of the chromosome 1q41q42.12 region, and the candidate gene DISP1, in patients with CDH.
Pober et al., Boston, United States. In Am J Med Genet A, 2010
report of 1st de novo DISP1 point mutation in patient with congenital diaphragmatic hernia (CDH); finding with Disp1 embryonic mouse diaphragm and lung expression and previously reported 1q41q42 aberrations in CDH suggests DISP1 may be CDH candidate gene
Truncating loss-of-function mutations of DISP1 contribute to holoprosencephaly-like microform features in humans.
Muenke et al., Bethesda, United States. In Hum Genet, 2009
describe two independent families with truncating mutations in DISP1 that resemble the cardinal craniofacial and neuro-developmental features of a recently described microdeletion syndrome that includes this gene
Zebrafish con/disp1 reveals multiple spatiotemporal requirements for Hedgehog-signaling in craniofacial development.
Ahlgren et al., Chicago, United States. In Bmc Dev Biol, 2008
Study shows that disp1 is required for post-migratory cranial neural crest cells (CNCC) to become properly patterned within the first arch, while the gene is dispensable for CNCC condensation and patterning in more posterior arches.
Disp1 regulates growth of mammalian long bones through the control of Ihh distribution.
McMahon et al., Cambridge, United States. In Dev Biol, 2008
Disp1 regulates growth of mammalian long bones through the control of Indian hedgehog distribution.
The discovery of microdeletion syndromes in the post-genomic era: review of the methodology and characterization of a new 1q41q42 microdeletion syndrome.
Shaikh et al., Spokane, United States. In Genet Med, 2007
The smallest region of overlap is 1.17 Mb and encompasses five genes, including DISP1, a gene involved in the sonic hedgehog signaling pathway, the deletion of which has been implicated in holoprosencephaly in mice.
Hedgehog signaling pathway and gastric cancer.
Katoh et al., Japan. In Cancer Biol Ther, 2005
Human SHH, IHH, DHH (Hedgehog homologs), HHAT (Hedgehog acyltransferase), HHIP (Hedgehog-interacting protein), DISP1, DISP2, DISP3 (Dispatched homologs), PTCH1, PTCH2 (Patched homologs), SMO (Smoothened homolog), KIF27, KIF7 (Costal-2 homologs), STK36 (Fused homolog), SUFU (SuFu homolog), DZIP1 (Iguana homolog), GLI1, GLI2 and GLI3 (Cubitus interruptus homologs) are implicated in the Hedgehog signaling.
Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched.
Beachy et al., Baltimore, United States. In Cell, 2002
Here, we demonstrate that one of two murine homologs, mDispA, can rescue disp function in Drosophila and is essential for all Hh patterning activities examined in the early mouse embryo.
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