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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Jan 2016.

Disrupted in schizophrenia 1

DISC1, disrupted-in-schizophrenia 1
This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, DTNBP1, V1a, HAD, Nudel
Papers using DISC1 antibodies
Modification of a PCR-based site-directed mutagenesis method
Supplier
Aruga Jun et al., In Scientific Reports, 1996
... Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes ...
Papers on DISC1
Misassembly of full-length Disrupted-in-Schizophrenia 1 protein is linked to altered dopamine homeostasis and behavioral deficits.
New
Korth et al., Düsseldorf, Germany. In Mol Psychiatry, 12 Feb 2016
UNASSIGNED: Disrupted-in-schizophrenia 1 (DISC1) is a mental illness gene first identified in a Scottish pedigree.
Lead neurotoxicity: exploring the potential impact of lead substitution in zinc-finger proteins on mental health.
New
Austin et al., Lewiston, United States. In Metallomics, 08 Feb 2016
The zinc-finger proteins potentially impacted by lead include DNA methyltransferase 1 (DNMT1) and Presenilin 1 and 2 (PSEN1/2) in Alzheimer's disease, the dopamine receptor in Parkinson's disease, and the NMDA receptor, zinc-finger protein 804A (ZNF804A), and disrupted-in-schizophrenia 1 (DISC1)-binding zinc-finger (DBZ) in schizophrenia.
Genome Sequencing of Autism-Affected Families Reveals Disruption of Putative Noncoding Regulatory DNA.
New
Eichler et al., Seattle, United States. In Am J Hum Genet, 07 Feb 2016
In addition, we provide evidence of gene-disruptive CNVs (in DISC1, WNT7A, RBFOX1, and MBD5), as well as smaller de novo CNVs and exon-specific SNVs missed by exome sequencing in neurodevelopmental genes (e.g., CANX, SAE1, and PIK3CA).
Utility and validity of DISC1 mouse models in biological psychiatry.
New
Sawa et al., Kyoto, Japan. In Neuroscience, 05 Feb 2016
The discovery of Disrupted-in-schizophrenia 1 (DISC1) gene was one of major driving forces that have contributed to the progress.
Early postnatal GABAA receptor modulation reverses deficits in neuronal maturation in a conditional neurodevelopmental mouse model of DISC1.
New
Kamiya et al., Baltimore, United States. In Mol Psychiatry, 05 Feb 2016
We report that prefrontal cortex (PFC)-specific postnatal knockdown of DISC1 via in utero electroporation combined with an inducible knockdown expression system drives deficits in synaptic GABAA function and dendritic development in pyramidal neurons, as well as abnormalities in sensorimotor gating, albeit without profound memory deficits.
Genetic assessment of additional endophenotypes from the Consortium on the Genetics of Schizophrenia Family Study.
New
Braff et al., San Diego, United States. In Schizophr Res, 31 Jan 2016
Linkage analyses performed using a genome-wide SNP array further identified significant or suggestive linkage for six of the candidate endophenotypes, with several genes of interest located beneath the linkage peaks (e.g., CSMD1, DISC1, DLGAP2, GRIK2, GRIN3A, and SLC6A3).
Disrupted in schizophrenia 1 (DISC1) L100P mutants have impaired activity-dependent plasticity in vivo and in vitro.
New
Corvin et al., Dublin, Ireland. In Transl Psychiatry, 31 Dec 2015
The gene disrupted in schizophrenia 1 (DISC1) has been associated with increased risk for neuropsychiatric conditions.
Missense mutation in DISC1 C-terminal coiled-coil has GSK3β signaling and sex-dependent behavioral effects in mice.
New
Clapcote et al., Leeds, United Kingdom. In Sci Rep, 31 Dec 2015
Disrupted-in-Schizophrenia 1 (DISC1) is a risk factor for schizophrenia and affective disorders.
Association analysis of DISC1 gene polymorphisms with Attention-Deficit Hyperactivity Disorder in Iranian population.
New
Darvish et al., Tehrān, Iran. In Pak J Med Sci, Sep 2015
METHODS: In this research work, for the first time, we investigated the association of three SNPs (rs11122330, rs6675281 and rs11122319) in the DISC1 gene with ADHD in Iranian population.
NEURODEVELOPMENT. Adult cortical plasticity depends on an early postnatal critical period.
New
Impact
Hardingham et al., Rockville, United States. In Science, Aug 2015
Transient neonatal disruption of signaling via the C-terminal domain of "disrupted in schizophrenia 1" (DISC1)—a molecule implicated in psychiatric disorders—resulted in a lack of long-term potentiation (LTP) (persistent strengthening of synapses) and experience-dependent potentiation in adulthood.
Interneuronal DISC1 regulates NRG1-ErbB4 signalling and excitatory-inhibitory synapse formation in the mature cortex.
Sawa et al., Baltimore, United States. In Nat Commun, 2014
DISC1 is a multifunctional scaffold protein that mediates many cellular processes.
Synaptic dysregulation in a human iPS cell model of mental disorders.
Impact
Ming et al., Baltimore, United States. In Nature, 2014
Here we generated induced pluripotent stem (iPS) cells from four members of a family in which a frameshift mutation of disrupted in schizophrenia 1 (DISC1) co-segregated with major psychiatric disorders and we further produced different isogenic iPS cell lines via gene editing.
DISC1 variants 37W and 607F disrupt its nuclear targeting and regulatory role in ATF4-mediated transcription.
GeneRIF
Millar et al., Edinburgh, United Kingdom. In Hum Mol Genet, 2012
Data show that Disrupted-In-Schizophrenia 1 (DISC1) interacts with the transcription factor activating transcription factor 4 (ATF4) in the nucleus, and the common variant 607F additionally reduces DISC1/ATF4 interaction.
The effect of DISC1 on regional gray matter density of schizophrenia in Han Chinese population.
GeneRIF
Zhang et al., Guangzhou, China. In Neurosci Lett, 2012
The DISC1 variant rs821597 may confer risk for schizophrenia by its effects on the regional gray matter in left parahippocampal gyrus and right orbitofrontal cortex with other risk factors for schizophrenia in Han Chinese population.
Interplay between DISC1 and GABA signaling regulates neurogenesis in mice and risk for schizophrenia.
Impact
GeneRIF
Ming et al., Baltimore, United States. In Cell, 2012
Study uncovers an interplay between intrinsic DISC1 and extrinsic GABA signaling, two schizophrenia susceptibility pathways.
DISC1 conditioned GWAS for psychosis proneness in a large Finnish birth cohort.
GeneRIF
Hennah et al., Helsinki, Finland. In Plos One, 2011
DISC1 conditioned genome-wide association study for psychosis proneness in a large Finnish birth cohort.
Disrupted-in-schizophrenia (DISC1) functions presynaptically at glutamatergic synapses.
GeneRIF
LoTurco et al., United States. In Plos One, 2011
Disrupted-in-schizophrenia (DISC1) functions presynaptically at glutamatergic synapses
Linking neurodevelopmental and synaptic theories of mental illness through DISC1.
Impact
GeneRIF
Sawa et al., United States. In Nat Rev Neurosci, 2011
The describation of this review that the linking neurodevelopmental and synape of mental disorders through DISC1.
DISC1-dependent switch from progenitor proliferation to migration in the developing cortex.
Impact
GeneRIF
Sawa et al., Baltimore, United States. In Nature, 2011
a dual role for DISC1 in corticogenesis and indicate that phosphorylation of this protein at S710 activates a key developmental switch
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