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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 26 Mar 2014.

Disrupted in schizophrenia 1

DISC1, disrupted-in-schizophrenia 1
This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, DTNBP1, V1a, HAD, Nudel
Papers using DISC1 antibodies
Modification of a PCR-based site-directed mutagenesis method
Supplier
Aruga Jun et al., In Scientific Reports, 1996
... Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes ...
Papers on DISC1
The polymorphism of YWHAE, a gene encoding 14-3-3epsilon, and orbitofrontal sulcogyral pattern in patients with schizophrenia and healthy subjects.
New
Suzuki et al., Toyama, Japan. In Prog Neuropsychopharmacol Biol Psychiatry, 03 Jul 2014
This magnetic resonance imaging study investigated the relationship between the polymorphism of YWHAE (rs28365859), a gene encoding 14-3-3epsilon that is a Disrupted-in-Schizophrenia 1 (DISC1)-interacting molecule associated with neuronal development, and the OFC subtypes of the 'H-shaped' sulcus (Types I, II, and III) in a Japanese sample of 72 schizophrenia patients and 86 healthy controls.
DBZ, a CNS-specific DISC1 binding protein, positively regulates oligodendrocyte differentiation.
New
Tohyama et al., Suita, Japan. In Glia, 31 May 2014
Here we report that DBZ, a central nervous system (CNS)-specific member of the DISC1 interactome, positively regulates the oligodendrocyte (OL) differentiation in vivo and in vitro.
18F-ASEM, a Radiolabeled Antagonist for Imaging the α7-Nicotinic Acetylcholine Receptor with PET.
New
Dannals et al., Baltimore, United States. In J Nucl Med, 20 Mar 2014
The brain regional distribution of (18)F-ASEM in baseline and blockade were evaluated in DISC1 mice (dissection) and baboons (PET).
Disrupted in Schizophrenia 1 Modulates Medial Prefrontal Cortex Pyramidal Neuron Activity Through cAMP Regulation of Transient Receptor Potential C and Small-Conductance K(+) Channels.
New
Yeckel et al., New Haven, United States. In Biol Psychiatry, 20 Feb 2014
BACKGROUND: Disrupted in schizophrenia 1 (DISC1) is a protein implicated in schizophrenia, bipolar disorder, major depressive disorder, and autism.
DISC1 (disrupted-in-schizophrenia-1) regulates differentiation of oligodendrocytes.
New
Ito et al., Suita, Japan. In Plos One, Dec 2013
Disrupted-in-schizophrenia 1 (DISC1) is a gene disrupted by a translocation, t(1;11) (q42.1;q14.3),
Involvement of Genetic and Environmental Factors in the Onset of Depression.
Review
New
Kim et al., Nagoya, Japan. In Exp Neurobiol, Dec 2013
When mice with the disrupted in schizophrenia 1 (DISC1) abnormal gene received isolated rearing stress, depression-like abnormal behaviors and decreased gene expression of tyrosine hydroxylase in the frontal cortex by epigenetical suppression via DNA methylation were observed.
Revisiting disrupted-in-schizophrenia 1 as a scaffold protein.
Review
New
Korth et al., In Biol Chem, Dec 2013
Disrupted-in-Schizophrenia 1 (DISC1) is a widely-accepted genetic risk factor for schizophrenia and many other major mental illnesses.
Human brain imaging studies of DISC1 in schizophrenia, bipolar disorder and depression: a systematic review.
Review
New
Blackwood et al., Edinburgh, United Kingdom. In Schizophr Res, Jun 2013
Disrupted-in-Schizophrenia 1 (DISC1) is a well researched candidate gene for schizophrenia and affective disorders with a range of functions relating to neurodevelopment.
Evidence for single nucleotide polymorphisms and their association with bipolar disorder.
Review
Szczepankiewicz, Poznań, Poland. In Neuropsychiatr Dis Treat, 2012
The review of association data reveals evidence for several genes (SLC6A4/5-HTT [serotonin transporter gene], BDNF [brain-derived neurotrophic factor], DAOA [D-amino acid oxidase activator], DTNBP1 [dysbindin], NRG1 [neuregulin 1], DISC1 [disrupted in schizophrenia 1]) to be crucial candidates in BD, whereas numerous genome-wide association studies conducted in BD indicate polymorphisms in two genes (CACNA1C [calcium channel, voltage-dependent, L type, alpha 1C subunit], ANK3 [ankyrin 3]) replicated for association with BD in most of these studies.
DISC1 mouse models as a tool to decipher gene-environment interactions in psychiatric disorders.
Review
Jaaro-Peled et al., Baltimore, United States. In Front Behav Neurosci, 2012
DISC1 was discovered in a Scottish pedigree in which a chromosomal translocation that breaks this gene segregates with psychiatric disorders, mainly depression and schizophrenia.
DISC1 variants 37W and 607F disrupt its nuclear targeting and regulatory role in ATF4-mediated transcription.
GeneRIF
Millar et al., Edinburgh, United Kingdom. In Hum Mol Genet, 2012
Data show that Disrupted-In-Schizophrenia 1 (DISC1) interacts with the transcription factor activating transcription factor 4 (ATF4) in the nucleus, and the common variant 607F additionally reduces DISC1/ATF4 interaction.
The effect of DISC1 on regional gray matter density of schizophrenia in Han Chinese population.
GeneRIF
Zhang et al., Guangzhou, China. In Neurosci Lett, 2012
The DISC1 variant rs821597 may confer risk for schizophrenia by its effects on the regional gray matter in left parahippocampal gyrus and right orbitofrontal cortex with other risk factors for schizophrenia in Han Chinese population.
Interplay between DISC1 and GABA signaling regulates neurogenesis in mice and risk for schizophrenia.
Impact
GeneRIF
Ming et al., Baltimore, United States. In Cell, 2012
Study uncovers an interplay between intrinsic DISC1 and extrinsic GABA signaling, two schizophrenia susceptibility pathways.
DISC1 conditioned GWAS for psychosis proneness in a large Finnish birth cohort.
GeneRIF
Hennah et al., Helsinki, Finland. In Plos One, 2011
DISC1 conditioned genome-wide association study for psychosis proneness in a large Finnish birth cohort.
Disrupted-in-schizophrenia (DISC1) functions presynaptically at glutamatergic synapses.
GeneRIF
LoTurco et al., United States. In Plos One, 2011
Disrupted-in-schizophrenia (DISC1) functions presynaptically at glutamatergic synapses
Linking neurodevelopmental and synaptic theories of mental illness through DISC1.
Review
Impact
GeneRIF
Sawa et al., United States. In Nat Rev Neurosci, 2011
The describation of this review that the linking neurodevelopmental and synape of mental disorders through DISC1.
DISC1-dependent switch from progenitor proliferation to migration in the developing cortex.
Impact
GeneRIF
Sawa et al., Baltimore, United States. In Nature, 2011
a dual role for DISC1 in corticogenesis and indicate that phosphorylation of this protein at S710 activates a key developmental switch
Psychiatric disorders: The risk of DISC — at the synapse.
Impact
Danovi, In Nat Rev Neurosci, 2010
DISC1 negatively regulates synaptic strength by inhibiting the TNIK-dependent stabilization of postsynaptic proteins.
GSK3 signalling in neural development.
Review
Impact
Zhou et al., Baltimore, United States. In Nat Rev Neurosci, 2010
These recent advances suggest that GSK3 is a crucial node that mediates various cellular processes that are controlled by multiple signalling molecules--for example, disrupted in schizophrenia 1 (DISC1), partitioning defective homologue 3 (PAR3), PAR6 and Wnt proteins--that regulate neurodevelopment.
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