gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 20 May 2015.

Disrupted in schizophrenia 1

DISC1, disrupted-in-schizophrenia 1
This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, DTNBP1, V1a, HAD, Nudel
Papers using DISC1 antibodies
Modification of a PCR-based site-directed mutagenesis method
Supplier
Aruga Jun et al., In Scientific Reports, 1996
... Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes ...
Papers on DISC1
Boymaw, overexpressed in brains with major psychiatric disorders, may encode a small protein to inhibit mitochondrial function and protein translation.
New
Zhou et al., San Diego, United States. In Am J Med Genet B Neuropsychiatr Genet, 30 Jun 2015
Our recent studies found that the DISC1-Boymaw fusion protein is localized in mitochondria and inhibits oxidoreductase activity, rRNA expression, and protein translation.
Protein-protein and Peptide-protein Interactions of NudE-like 1 (Ndel1): A Protein Involved in Schizophrenia.
New
Yonamine et al., São Paulo, Brazil. In Curr Protein Pept Sci, 05 Jun 2015
The most studied SCZ risk gene is the Disrupted-in-Schizophrenia 1 (DISC1) gene, which functions seem to depend on the binding with cytoskeleton proteins, as the Nuclear-distribution gene E homolog like-1 (Ndel1) protein among others.
Resequencing and association analysis of coding regions at twenty candidate genes suggest a role for rare risk variation at AKAP9 and protective variation at NRXN1 in schizophrenia susceptibility.
New
Costas et al., Santiago de Compostela, Spain. In J Psychiatr Res, 22 May 2015
This multistep study attempted to find low-frequency variants of high effect at coding regions of eleven schizophrenia susceptibility genes supported by genome-wide association studies (GWAS) and nine genes for the DISC1 interactome, a susceptibility gene-set.
Disturbance of oligodendrocyte function plays a key role in the pathogenesis of schizophrenia and major depressive disorder.
Review
New
Tohyama et al., Ōsaka, Japan. In Biomed Res Int, Dec 2014
We previously reported that abnormalities of disrupted-in-Schizophrenia-1 (DISC1) and DISC1 binding zinc finger (DBZ) might cause major psychiatric disorders such as SZ.
Schizophrenia and Depression Co-Morbidity: What We have Learned from Animal Models.
Review
New
Wong et al., Toronto, Canada. In Front Psychiatry, Dec 2014
Current models which demonstrate endophenotypes of both schizophrenia and depression are reviewed here, including models of CUB and SUSHI multiple domains 1, PDZ and LIM domain 5, glutamate Delta 1 receptor, diabetic db/db mice, neuropeptide Y, disrupted in schizophrenia 1, and its interacting partners, reelin, maternal immune activation, and social isolation.
Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1.
New
Pratt et al., Glasgow, United Kingdom. In Transl Psychiatry, Dec 2014
UNASSIGNED: Considerable evidence implicates DISC1 as a susceptibility gene for multiple psychiatric diseases.
Alterations in dendrite and spine morphology of cortical pyramidal neurons in DISC1-binding zinc finger protein (DBZ) knockout mice.
New
Tohyama et al., Suita, Japan. In Front Neuroanat, Dec 2014
DISC1-binding zinc finger protein (DBZ) was first identified as a Disrupted-In-Schizophrenia1 (DISC1) binding partner.
Synaptic dysregulation in a human iPS cell model of mental disorders.
New
Impact
Ming et al., Baltimore, United States. In Nature, Dec 2014
Here we generated induced pluripotent stem (iPS) cells from four members of a family in which a frameshift mutation of disrupted in schizophrenia 1 (DISC1) co-segregated with major psychiatric disorders and we further produced different isogenic iPS cell lines via gene editing.
Disrupted-In-Schizophrenia-1 (DISC1) interactome and mental disorders: impact of mouse models.
Review
New
Roder et al., Toronto, Canada. In Neurosci Biobehav Rev, Sep 2014
Disrupted-In-Schizophrenia-1 (DISC1) has captured much attention because it predisposes individuals to a wide range of mental illnesses.
Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system.
Review
New
Brown et al., Bristol, United Kingdom. In Eur J Neurosci, Apr 2014
The disrupted in schizophrenia 1 (DISC1) gene is found at the breakpoint of an inherited chromosomal translocation, and segregates with major mental illnesses.
[Brain activation as endophenotype for investigating genetics of depression].
Review
Aleman et al., In Tijdschr Psychiatr, 2013
We showed that the disc1, comt and npy genes were associated with brain activation patterns comparable to those seen in patients with depression.
DISC1 variants 37W and 607F disrupt its nuclear targeting and regulatory role in ATF4-mediated transcription.
GeneRIF
Millar et al., Edinburgh, United Kingdom. In Hum Mol Genet, 2012
Data show that Disrupted-In-Schizophrenia 1 (DISC1) interacts with the transcription factor activating transcription factor 4 (ATF4) in the nucleus, and the common variant 607F additionally reduces DISC1/ATF4 interaction.
The effect of DISC1 on regional gray matter density of schizophrenia in Han Chinese population.
GeneRIF
Zhang et al., Guangzhou, China. In Neurosci Lett, 2012
The DISC1 variant rs821597 may confer risk for schizophrenia by its effects on the regional gray matter in left parahippocampal gyrus and right orbitofrontal cortex with other risk factors for schizophrenia in Han Chinese population.
Interplay between DISC1 and GABA signaling regulates neurogenesis in mice and risk for schizophrenia.
Impact
GeneRIF
Ming et al., Baltimore, United States. In Cell, 2012
Study uncovers an interplay between intrinsic DISC1 and extrinsic GABA signaling, two schizophrenia susceptibility pathways.
DISC1 conditioned GWAS for psychosis proneness in a large Finnish birth cohort.
GeneRIF
Hennah et al., Helsinki, Finland. In Plos One, 2011
DISC1 conditioned genome-wide association study for psychosis proneness in a large Finnish birth cohort.
Disrupted-in-schizophrenia (DISC1) functions presynaptically at glutamatergic synapses.
GeneRIF
LoTurco et al., United States. In Plos One, 2011
Disrupted-in-schizophrenia (DISC1) functions presynaptically at glutamatergic synapses
Linking neurodevelopmental and synaptic theories of mental illness through DISC1.
Review
Impact
GeneRIF
Sawa et al., United States. In Nat Rev Neurosci, 2011
The describation of this review that the linking neurodevelopmental and synape of mental disorders through DISC1.
DISC1-dependent switch from progenitor proliferation to migration in the developing cortex.
Impact
GeneRIF
Sawa et al., Baltimore, United States. In Nature, 2011
a dual role for DISC1 in corticogenesis and indicate that phosphorylation of this protein at S710 activates a key developmental switch
Psychiatric disorders: The risk of DISC — at the synapse.
Impact
Danovi, In Nat Rev Neurosci, 2010
DISC1 negatively regulates synaptic strength by inhibiting the TNIK-dependent stabilization of postsynaptic proteins.
share on facebooktweetadd +1mail to friends