GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Disrupted in schizophrenia 1
DISC1, disrupted-in-schizophrenia 1
This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] (from
NCBI)
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Papers using
DISC1
antibodies
Modification of a PCR-based site-directed mutagenesis method
Supplier
In Scientific Reports, 1996
... Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes ...
Papers on
DISC1
Plasma Ndel1 enzyme activity is reduced in patients with schizophrenia - A potential biomarker?
New
São Paulo, Brazil. In J Psychiatr Res, 31 May 2013
Ndel1 oligopeptidase interacts with schizophrenia (SCZ) risk gene product DISC1 and mediates several functions related to neurite outgrowth and neuronal migration.
Behavioral Phenotypes in Schizophrenic Animal Models With Multiple Combinations of Genetic and Environmental Factors.
New
Japan. In J Pharmacol Sci, 01 Apr 2013
Genetic [e.g., Disrupted-in-schizophrenia 1 (DISC1), Neuregulin-1 (NRG1)] and environmental factors (e.g., maternal viral infection, obstetric complications, social stress) may act during the developmental period to increase the incidence of schizophrenia.
Gene expression profiling in treatment-naive schizophrenia patients identifies abnormalities in biological pathways involving AKT1 that are corrected by antipsychotic medication.
New
Sri Jayewardenepura Kotte, Sri Lanka. In Int J Neuropsychopharmacol, 27 Mar 2013
This analysis identified 624 genes with altered expression (208 up-regulated, 416 down-regulated) prior to antipsychotic treatment (p < 0.05) including schizophrenia-associated genes AKT1, DISC1 and DGCR6.
DISC1 in adult ADHD patients: An association study in two European samples.
New
Bergen, Norway. In Am J Med Genet B Neuropsychiatr Genet, 06 Mar 2013
The DISC1 gene was named after its discovery in a Scottish pedigree with schizophrenia (SCZ) patients.
A Disc1 mutation differentially affects neurites and spines in hippocampal and cortical neurons.
New
New York City, United States. In Mol Cell Neurosci, 06 Mar 2013
A balanced chromosomal translocation segregating with schizophrenia and affective disorders in a large Scottish family disrupting DISC1 implicated this gene as a susceptibility gene for major mental illness.
The possible role of the Akt signaling pathway in schizophrenia.
Review
New
Guangzhou, China. In Brain Res, Sep 2012
More recently, the role of Akt signaling in the functions of schizophrenia susceptibility genes such as disrupted-in-schizophrenia 1 (DISC-1), neuregulin-1 (NRG-1) and dysbindin-1 has been reported.
Aggregated proteins in schizophrenia and other chronic mental diseases: DISC1opathies.
Review
New
Düsseldorf, Germany. In Prion, Apr 2012
The DISC1 (Disrupted-in-schizophrenia 1) gene is considered among the most promising candidate genes for CMD having been identified as linked to CMD in a Scottish pedigree and having since been found to associate to various phenotypes of CMD.
Interplay between DISC1 and GABA signaling regulates neurogenesis in mice and risk for schizophrenia.
New
Impact
Baltimore, United States. In Cell, Apr 2012
Here we show that regulation of dendritic development of newborn neurons by Disrupted-in-Schizophrenia 1 (DISC1) during adult hippocampal neurogenesis requires neurotransmitter GABA-induced, NKCC1-dependent depolarization through a convergence onto the AKT-mTOR pathway.
Molecular links between mitochondrial dysfunctions and schizophrenia.
Review
New
South Korea. In Mol Cells, Feb 2012
Growing pieces of evidence indicate that schizophrenia has pathological components that can be attributable to the abnormalities of mitochondrial function, which is supported by the recent finding suggesting mitochondrial roles for Disrupted-in-Schizophrenia 1 (DISC1).
Linking neurodevelopmental and synaptic theories of mental illness through DISC1.
Review
Impact
GeneRIF
United States. In Nat Rev Neurosci, 2011
The describation of this review that the linking neurodevelopmental and synape of mental disorders through DISC1.
Genetic predisposition to schizophrenia: what did we learn and what does the future hold?
Review
Budapest, Hungary. In Neuropsychopharmacol Hung, 2011
Vulnerability in DISC1, NRG1, DTNBP1, RGS4, KCNH2, COMT, AKT1 and other putative schizophrenia genes, together with copy number variants, leave unexplained the vast majority of diseased cases.
Common DISC1 polymorphisms disrupt Wnt/GSK3β signaling and brain development.
GeneRIF
Cambridge, United States. In Neuron, 2011
DISC1 variants impair Wnt signaling and brain development and elucidate a possible mechanism for their role in neuropsychiatric phenotypes.
Interaction between FEZ1 and DISC1 in regulation of neuronal development and risk for schizophrenia.
GeneRIF
Baltimore, United States. In Neuron, 2011
DISC1 and fasciculation and elongation protein (Fez)zeta-1 regulate cell positioning and morphogenesis of newborn neurons in hippocampus.
[PolyI:C-induced neurodevelopmental animal model for schizophrenia].
Review
Nagoya, Japan. In Nihon Shinkei Seishin Yakurigaku Zasshi, 2011
Genetic susceptibility factors for schizophrenia, such as neuregulinl, dysbindin and disrupted-in-schizophrenia 1 (DISC1), have recently been reported, some of which play a role in neurodevelopment.
Genetic and functional analyses identify DISC1 as a novel callosal agenesis candidate gene.
GeneRIF
San Francisco, United States. In Am J Med Genet A, 2011
our results suggest a significant role for DISC1 in corpus callosum development
DISC1-dependent switch from progenitor proliferation to migration in the developing cortex.
Impact
GeneRIF
Baltimore, United States. In Nature, 2011
a dual role for DISC1 in corticogenesis and indicate that phosphorylation of this protein at S710 activates a key developmental switch
Sequencing of DISC1 pathway genes reveals increased burden of rare missense variants in schizophrenia patients from a northern Swedish population.
GeneRIF
Belgium. In Plos One, 2010
The contribution of genetic variation in DISC1 and 10 of its interaction partners to schizophrenia susceptibility in an isolated northern Swedish population, is reported.
Psychiatric disorders: The risk of DISC — at the synapse.
Impact
In Nat Rev Neurosci, 2010
DISC1 negatively regulates synaptic strength by inhibiting the TNIK-dependent stabilization of postsynaptic proteins.
GSK3 signalling in neural development.
Review
Impact
Baltimore, United States. In Nat Rev Neurosci, 2010
These recent advances suggest that GSK3 is a crucial node that mediates various cellular processes that are controlled by multiple signalling molecules--for example, disrupted in schizophrenia 1 (DISC1), partitioning defective homologue 3 (PAR3), PAR6 and Wnt proteins--that regulate neurodevelopment.
