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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Aug 2015.

Disrupted in schizophrenia 1

DISC1, disrupted-in-schizophrenia 1
This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, DTNBP1, V1a, HAD, Nudel
Papers using DISC1 antibodies
Modification of a PCR-based site-directed mutagenesis method
Supplier
Aruga Jun et al., In Scientific Reports, 1996
... Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes ...
Papers on DISC1
The cortical thickness phenotype of individuals with DISC1 translocation resembles schizophrenia.
New
Lawrie et al., In J Clin Invest, 24 Sep 2015
BACKGROUND: The disrupted in schizophrenia 1 (DISC1) gene locus was originally identified in a Scottish pedigree with a high incidence of psychiatric disorders that is associated with a balanced t(1;11)(q42.1;q14.3)
Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate.
New
Young-Pearse et al., Boston, United States. In Cell Rep, 19 Sep 2015
UNASSIGNED: Genetic and clinical association studies have identified disrupted in schizophrenia 1 (DISC1) as a candidate risk gene for major mental illness.
Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition.
New
Roder et al., Vancouver, Canada. In Neuropsychopharmacology, 14 Sep 2015
Phosphodiesterase-4B (PDE4B) is an important phosphodiesterase in the hippocampal formation, is a major Disrupted in Schizophrenia 1 (DISC1) binding partner and is itself a risk gene for psychiatric illness.
The Key Regulator for Language and Speech Development, FOXP2, is a Novel Substrate for SUMOylation.
New
Yang et al., Birmingham, United States. In J Cell Biochem, 24 Aug 2015
Finally, our functional analysis using reporter gene assays showed that SUMOylation may modulate transcriptional activity of FOXP2 in regulating downstream target genes (DISC1, SRPX2 and MiR200c).
DISC1 regulates expression of the neurotrophin VGF through the PI3K/AKT/CREB pathway.
New
Requena et al., Santiago de Compostela, Spain. In J Neurochem, 24 Aug 2015
UNASSIGNED: Disrupted in schizophrenia (DISC1) is a risk factor for chronic mental disease.
NEURODEVELOPMENT. Adult cortical plasticity depends on an early postnatal critical period.
New
Impact
Hardingham et al., Rockville, United States. In Science, 24 Aug 2015
Transient neonatal disruption of signaling via the C-terminal domain of "disrupted in schizophrenia 1" (DISC1)—a molecule implicated in psychiatric disorders—resulted in a lack of long-term potentiation (LTP) (persistent strengthening of synapses) and experience-dependent potentiation in adulthood.
Caution When Diagnosing Your Mouse with Schizophrenia: The Use and Misuse of Model Animals for Understanding Psychiatric Disorders.
Review
New
Josselyn et al., Toronto, Canada. In Biol Psychiatry, Jun 2015
As disrupted-in-schizophrenia 1 (DISC1) is a genetic risk factor across a spectrum of psychiatric disorders, we focus on the results of studies using mice with various mutations of DISC1.
Schizophrenia and Depression Co-Morbidity: What We have Learned from Animal Models.
Review
New
Wong et al., Toronto, Canada. In Front Psychiatry, Dec 2014
Current models which demonstrate endophenotypes of both schizophrenia and depression are reviewed here, including models of CUB and SUSHI multiple domains 1, PDZ and LIM domain 5, glutamate Delta 1 receptor, diabetic db/db mice, neuropeptide Y, disrupted in schizophrenia 1, and its interacting partners, reelin, maternal immune activation, and social isolation.
Disturbance of oligodendrocyte function plays a key role in the pathogenesis of schizophrenia and major depressive disorder.
Review
New
Tohyama et al., Ōsaka, Japan. In Biomed Res Int, Dec 2014
We previously reported that abnormalities of disrupted-in-Schizophrenia-1 (DISC1) and DISC1 binding zinc finger (DBZ) might cause major psychiatric disorders such as SZ.
Synaptic dysregulation in a human iPS cell model of mental disorders.
New
Impact
Ming et al., Baltimore, United States. In Nature, Dec 2014
Here we generated induced pluripotent stem (iPS) cells from four members of a family in which a frameshift mutation of disrupted in schizophrenia 1 (DISC1) co-segregated with major psychiatric disorders and we further produced different isogenic iPS cell lines via gene editing.
Disrupted-In-Schizophrenia-1 (DISC1) interactome and mental disorders: impact of mouse models.
Review
New
Roder et al., Toronto, Canada. In Neurosci Biobehav Rev, Sep 2014
Disrupted-In-Schizophrenia-1 (DISC1) has captured much attention because it predisposes individuals to a wide range of mental illnesses.
[Brain activation as endophenotype for investigating genetics of depression].
Review
Aleman et al., In Tijdschr Psychiatr, 2013
We showed that the disc1, comt and npy genes were associated with brain activation patterns comparable to those seen in patients with depression.
DISC1 variants 37W and 607F disrupt its nuclear targeting and regulatory role in ATF4-mediated transcription.
GeneRIF
Millar et al., Edinburgh, United Kingdom. In Hum Mol Genet, 2012
Data show that Disrupted-In-Schizophrenia 1 (DISC1) interacts with the transcription factor activating transcription factor 4 (ATF4) in the nucleus, and the common variant 607F additionally reduces DISC1/ATF4 interaction.
The effect of DISC1 on regional gray matter density of schizophrenia in Han Chinese population.
GeneRIF
Zhang et al., Guangzhou, China. In Neurosci Lett, 2012
The DISC1 variant rs821597 may confer risk for schizophrenia by its effects on the regional gray matter in left parahippocampal gyrus and right orbitofrontal cortex with other risk factors for schizophrenia in Han Chinese population.
Interplay between DISC1 and GABA signaling regulates neurogenesis in mice and risk for schizophrenia.
Impact
GeneRIF
Ming et al., Baltimore, United States. In Cell, 2012
Study uncovers an interplay between intrinsic DISC1 and extrinsic GABA signaling, two schizophrenia susceptibility pathways.
DISC1 conditioned GWAS for psychosis proneness in a large Finnish birth cohort.
GeneRIF
Hennah et al., Helsinki, Finland. In Plos One, 2011
DISC1 conditioned genome-wide association study for psychosis proneness in a large Finnish birth cohort.
Disrupted-in-schizophrenia (DISC1) functions presynaptically at glutamatergic synapses.
GeneRIF
LoTurco et al., United States. In Plos One, 2011
Disrupted-in-schizophrenia (DISC1) functions presynaptically at glutamatergic synapses
Linking neurodevelopmental and synaptic theories of mental illness through DISC1.
Review
Impact
GeneRIF
Sawa et al., United States. In Nat Rev Neurosci, 2011
The describation of this review that the linking neurodevelopmental and synape of mental disorders through DISC1.
DISC1-dependent switch from progenitor proliferation to migration in the developing cortex.
Impact
GeneRIF
Sawa et al., Baltimore, United States. In Nature, 2011
a dual role for DISC1 in corticogenesis and indicate that phosphorylation of this protein at S710 activates a key developmental switch
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