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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 16 Apr 2015.

Disrupted in schizophrenia 1

DISC1, disrupted-in-schizophrenia 1
This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, DTNBP1, V1a, HAD, Nudel
Papers using DISC1 antibodies
Modification of a PCR-based site-directed mutagenesis method
Supplier
Aruga Jun et al., In Scientific Reports, 1996
... Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes ...
Papers on DISC1
Venlafaxine increases cell proliferation and regulates DISC1, PDE4B and NMDA receptor 2B expression in the hippocampus in chronic mild stress mice.
New
Zhang et al., Shenyang, China. In Eur J Pharmacol, 15 Jun 2015
Recent evidence has identified disrupted in schizophrenia-1 (DISC1) as an important genetic risk factor for the development of many psychiatric disorders, including major depressive disorders.
Disrupted-in-schizophrenia 1 regulates transport of ITPR1 mRNA for synaptic plasticity.
New
Kaibuchi et al., Nagoya, Japan. In Nat Neurosci, 30 Apr 2015
UNASSIGNED: Disrupted-in-schizophrenia 1 (DISC1) is a susceptibility gene for major psychiatric disorders, including schizophrenia.
Evaluating historical candidate genes for schizophrenia.
New
Sullivan et al., Chapel Hill, United States. In Mol Psychiatry, 10 Apr 2015
In this invited review, we consider the current status of 25 historical candidate genes for schizophrenia (for example, COMT, DISC1, DTNBP1 and NRG1).
Disturbance of oligodendrocyte function plays a key role in the pathogenesis of schizophrenia and major depressive disorder.
Review
New
Tohyama et al., Ōsaka, Japan. In Biomed Res Int, Dec 2014
We previously reported that abnormalities of disrupted-in-Schizophrenia-1 (DISC1) and DISC1 binding zinc finger (DBZ) might cause major psychiatric disorders such as SZ.
Schizophrenia and Depression Co-Morbidity: What We have Learned from Animal Models.
Review
New
Wong et al., Toronto, Canada. In Front Psychiatry, Dec 2014
Current models which demonstrate endophenotypes of both schizophrenia and depression are reviewed here, including models of CUB and SUSHI multiple domains 1, PDZ and LIM domain 5, glutamate Delta 1 receptor, diabetic db/db mice, neuropeptide Y, disrupted in schizophrenia 1, and its interacting partners, reelin, maternal immune activation, and social isolation.
Risk-associated coding synonymous SNPs in type 2 diabetes and neurodegenerative diseases: Genetic silence and the underrated association with splicing regulation and epigenetics.
New
Kouidou et al., Thessaloníki, Greece. In Mutat Res, Dec 2014
sSNPs introducing smaller Δscore changes (<1.5) in key proteins (INSR, IRS1, DISC1) were also correlated to pathological conditions.
Synaptic dysregulation in a human iPS cell model of mental disorders.
New
Impact
Ming et al., Baltimore, United States. In Nature, Dec 2014
Here we generated induced pluripotent stem (iPS) cells from four members of a family in which a frameshift mutation of disrupted in schizophrenia 1 (DISC1) co-segregated with major psychiatric disorders and we further produced different isogenic iPS cell lines via gene editing.
[The association of polymorphisms in SLC18A1, TPH1 H relngenes with risk of paranoid schizophrenia].
New
In Mol Biol (mosk), Jul 2014
We have developed a biochip for the analysis of polymorphisms in candidate genes for schizophrenia: DISC1, RELN, ZNF804A, PLXNA2, COMT, SLC18A41, CACNA1C, ANK3, TPH1, PLAA and SNAP-25.
Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system.
Review
New
Brown et al., Bristol, United Kingdom. In Eur J Neurosci, Apr 2014
The disrupted in schizophrenia 1 (DISC1) gene is found at the breakpoint of an inherited chromosomal translocation, and segregates with major mental illnesses.
[Brain activation as endophenotype for investigating genetics of depression].
Review
Aleman et al., In Tijdschr Psychiatr, 2013
We showed that the disc1, comt and npy genes were associated with brain activation patterns comparable to those seen in patients with depression.
Involvement of genetic and environmental factors in the onset of depression.
Review
Kim et al., Nagoya, Japan. In Exp Neurobiol, 2013
When mice with the disrupted in schizophrenia 1 (DISC1) abnormal gene received isolated rearing stress, depression-like abnormal behaviors and decreased gene expression of tyrosine hydroxylase in the frontal cortex by epigenetical suppression via DNA methylation were observed.
DISC1 variants 37W and 607F disrupt its nuclear targeting and regulatory role in ATF4-mediated transcription.
GeneRIF
Millar et al., Edinburgh, United Kingdom. In Hum Mol Genet, 2012
Data show that Disrupted-In-Schizophrenia 1 (DISC1) interacts with the transcription factor activating transcription factor 4 (ATF4) in the nucleus, and the common variant 607F additionally reduces DISC1/ATF4 interaction.
The effect of DISC1 on regional gray matter density of schizophrenia in Han Chinese population.
GeneRIF
Zhang et al., Guangzhou, China. In Neurosci Lett, 2012
The DISC1 variant rs821597 may confer risk for schizophrenia by its effects on the regional gray matter in left parahippocampal gyrus and right orbitofrontal cortex with other risk factors for schizophrenia in Han Chinese population.
Interplay between DISC1 and GABA signaling regulates neurogenesis in mice and risk for schizophrenia.
Impact
GeneRIF
Ming et al., Baltimore, United States. In Cell, 2012
Study uncovers an interplay between intrinsic DISC1 and extrinsic GABA signaling, two schizophrenia susceptibility pathways.
DISC1 conditioned GWAS for psychosis proneness in a large Finnish birth cohort.
GeneRIF
Hennah et al., Helsinki, Finland. In Plos One, 2011
DISC1 conditioned genome-wide association study for psychosis proneness in a large Finnish birth cohort.
Disrupted-in-schizophrenia (DISC1) functions presynaptically at glutamatergic synapses.
GeneRIF
LoTurco et al., United States. In Plos One, 2011
Disrupted-in-schizophrenia (DISC1) functions presynaptically at glutamatergic synapses
Linking neurodevelopmental and synaptic theories of mental illness through DISC1.
Review
Impact
GeneRIF
Sawa et al., United States. In Nat Rev Neurosci, 2011
The describation of this review that the linking neurodevelopmental and synape of mental disorders through DISC1.
DISC1-dependent switch from progenitor proliferation to migration in the developing cortex.
Impact
GeneRIF
Sawa et al., Baltimore, United States. In Nature, 2011
a dual role for DISC1 in corticogenesis and indicate that phosphorylation of this protein at S710 activates a key developmental switch
Psychiatric disorders: The risk of DISC — at the synapse.
Impact
Danovi, In Nat Rev Neurosci, 2010
DISC1 negatively regulates synaptic strength by inhibiting the TNIK-dependent stabilization of postsynaptic proteins.
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