Schizophrenia and Depression Co-Morbidity: What We have Learned from Animal Models.
Toronto, Canada. In Front Psychiatry, Dec 2014
Current models which demonstrate endophenotypes of both schizophrenia and depression are reviewed here, including models of CUB and SUSHI multiple domains 1, PDZ and LIM domain 5, glutamate Delta 1 receptor, diabetic db/db mice, neuropeptide Y, disrupted in schizophrenia 1, and its interacting partners, reelin, maternal immune activation, and social isolation.
Synaptic dysregulation in a human iPS cell model of mental disorders.
Baltimore, United States. In Nature, Dec 2014
Here we generated induced pluripotent stem (iPS) cells from four members of a family in which a frameshift mutation of disrupted in schizophrenia 1 (DISC1) co-segregated with major psychiatric disorders and we further produced different isogenic iPS cell lines via gene editing.
[The association of polymorphisms in SLC18A1, TPH1 H relngenes with risk of paranoid schizophrenia].
In Mol Biol (mosk), Jul 2014
We have developed a biochip for the analysis of polymorphisms in candidate genes for schizophrenia: DISC1, RELN, ZNF804A, PLXNA2, COMT, SLC18A41, CACNA1C, ANK3, TPH1, PLAA and SNAP-25.
Involvement of genetic and environmental factors in the onset of depression.
Nagoya, Japan. In Exp Neurobiol, 2013
When mice with the disrupted in schizophrenia 1 (DISC1) abnormal gene received isolated rearing stress, depression-like abnormal behaviors and decreased gene expression of tyrosine hydroxylase in the frontal cortex by epigenetical suppression via DNA methylation were observed.