Molecular links between mitochondrial dysfunctions and schizophrenia.
South Korea. In Mol Cells, Feb 2012
Growing pieces of evidence indicate that schizophrenia has pathological components that can be attributable to the abnormalities of mitochondrial function, which is supported by the recent finding suggesting mitochondrial roles for Disrupted-in-Schizophrenia 1 (DISC1).
Genetic predisposition to schizophrenia: what did we learn and what does the future hold?
Budapest, Hungary. In Neuropsychopharmacol Hung, 2011
Vulnerability in DISC1, NRG1, DTNBP1, RGS4, KCNH2, COMT, AKT1 and other putative schizophrenia genes, together with copy number variants, leave unexplained the vast majority of diseased cases.
GSK3 signalling in neural development.
Baltimore, United States. In Nat Rev Neurosci, 2010
These recent advances suggest that GSK3 is a crucial node that mediates various cellular processes that are controlled by multiple signalling molecules--for example, disrupted in schizophrenia 1 (DISC1), partitioning defective homologue 3 (PAR3), PAR6 and Wnt proteins--that regulate neurodevelopment.